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http://dx.doi.org/10.4162/nrp.2020.14.6.553

Vitamin D regulation of adipogenesis and adipose tissue functions  

Nimitphong, Hataikarn (Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University)
Park, Eunmi (Department of Food and Nutrition, Hannam University)
Lee, Mi-Jeong (Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resources, University of Hawaii)
Publication Information
Nutrition Research and Practice / v.14, no.6, 2020 , pp. 553-567 More about this Journal
Abstract
Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed.
Keywords
Cholecalciferol; adipogenesis; adipose function; obesity; metabolic diseases;
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