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http://dx.doi.org/10.4162/nrp.2015.9.5.472

Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice  

Park, Mi Hwa (Department of Food and Nutrition, College of Medical and Life Science, Silla University)
Nam, Young Hwa (Department of Food Science and Nutrition, Pusan National University)
Han, Ji-Sook (Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University)
Publication Information
Nutrition Research and Practice / v.9, no.5, 2015 , pp. 472-479 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice. MATERIALS/METHODS: For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w). RESULTS: A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice. CONCLUSIONS: These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
Keywords
Anti-diabetic effects; Sargassum coreanum extract; C57BL/KsJ-db/db mice; hyperglycemia; insulin resistance;
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