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http://dx.doi.org/10.4162/nrp.2012.6.4.301

Effect of quercetin on impaired immune function in mice exposed to irradiation  

Jung, Ji-Hye (Division of Biological Science, College of Science, Sookmyung Women's University)
Kang, Ji-In (Division of Biological Science, College of Science, Sookmyung Women's University)
Kim, Hyun-Sook (Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University)
Publication Information
Nutrition Research and Practice / v.6, no.4, 2012 , pp. 301-307 More about this Journal
Abstract
Radiation used in cancer treatment may cause side effects such as inflammation. Quercetin is a polyphenol that reduces inflammation. This study evaluated the recovery efficacy of quercetin on impaired immune function in irradiation-induced inflammatory mice. Quercetin administered at two concentrations of 10 and 40 mg/kg body weight was initiated 2 weeks before irradiation and was continued 30 days after irradiation. The animals exposed/not exposed to radiation were sacrificed on radiation days 10 and 30. Splenocyte proliferation, which was diminished after irradiation, was enhanced significantly by quercetin supplementation after 30 days of irradiation. Cytokine secretion increased in the radiation group compared to that in the non-radiation control group. After 30 days of radiation, interleukin (IL)-$1{\beta}$ and IL-6 secretion decreased significantly in the radiation-quercetin groups. When quercetin was administered for 44 days, it showed a possible protective effect against irradiation-induced inflammation in mice. Quercetin could be beneficial in the recovery of irradiation-induced increases in cytokine secretion.
Keywords
Quercetin; irradiation; cytokines; anti-inflammatory; mice;
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Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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