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http://dx.doi.org/10.4162/nrp.2010.4.4.259

Effects of resistance training on the inflammatory response  

Celle, Mariana C. (Department of Nutritional Sciences, University of Connecticut)
Fernandez, Maria Luz (Department of Nutritional Sciences, University of Connecticut)
Publication Information
Nutrition Research and Practice / v.4, no.4, 2010 , pp. 259-269 More about this Journal
Abstract
Resistance training (RT) is associated with reduced risk of low grade inflammation related diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data studying cytokines and exercise comes from endurance exercise. In contrast, evidence establishing a relationship between RT and inflammation is more limited. This review focuses on the cytokine responses both following an acute bout, and after chronic RT. In addition, the effect of RT on low grade systemic inflammation such as individuals at risk for type 2 diabetes is reviewed. Cytokines are secreted proteins that influence the survival, proliferation, and differentiation of immune cells and other organ systems. Cytokines function as intracellular signals and almost all cells in the body either secrete them or have cytokine receptors. Thus, understanding cytokine role in a specific physiological situation such as a bout of RT can be exceedingly complex. The overall effect of long term RT appears to ameliorate inflammation, but the specific effects on the inflammatory cytokine, tumor necrosis factor alpha are not clear, requiring further research. Furthermore, it is critical to differentiate between chronically and acute Interleukin-6 levels and its sources. The intensity of the RT and the characteristics of the training protocol may exert singular cytokine responses and as a result different adaptations to exercise. More research is needed in the area of RT in healthy populations, specifically sorting out gender and age RT acute responses. More importantly, studies are needed in obese individuals who are at high risk of developing low grade systemic inflammatory related diseases. Assuring adherence to the RT program is essential to get the benefits after overcoming the first acute RT responses. Hence RT could be an effective way to prevent, and delay low grade systemic inflammatory related diseases.
Keywords
Cytokines; IL-6; inflammatory markers; acute resistance exercise; resistance training;
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1 Riechman SE, Balasekaran G, Roth SM, Ferrell RE. Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol 2004;97:2214-9.   DOI   ScienceOn
2 Kones R The Jupiter study, CRP screening, and aggressive statin therapy-implications for the primary prevention of cardiovascular disease. Ther Adv Cardiovasc Dis 2009;3:309-15.   DOI   ScienceOn
3 Phillips SM. Resistance exercise: good for more than just Grandma and Grandpa's muscles. Appl Physiol Nutr Metab 2007;32: 1198-205.   DOI   ScienceOn
4 Steinacker JM, Lormes W, Reissnecker S, Liu Y. New aspects of the hormone and cytokine response to training. Eur J Appl Physiol 2004;91 :382-91.   DOI   ScienceOn
5 Olson TP, Dengel DR, Leon AS, Schmitz KH. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes 2007;31:996-1003.   DOI
6 Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, MunozCanoves P. Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy. Cell Metab 2008;7:33-44.   DOI   ScienceOn
7 Lehmann MJ, Lormes W, Opitz-Gress A, Steinacker JM, Netzer N, Foster C, Gastmann U. Training and overtraining: an overview and experimental results in endurance sports. J Sports Med Phys Fitness 1997;37:7-17.
8 Ramel A, Wagner KH, Elmadfa I. Correlations between plasma noradrenaline concentrations, antioxidants, and neutrophil counts after submaximal resistance exercise in men. Br J Sports Med 2004;38:E22.   DOI   ScienceOn
9 Ronn SG, Billestrup N, Mandrup-Poulsen T. Diabetes and suppressors of cytokine signaling proteins. Diabetes 2007;56:541-8.   DOI   ScienceOn
10 Woods JA, Lu Q, Lowder T. Exercise-induced modulation of macrophage function. Immunol Cell Biol 2000;78:545-53.   DOI   ScienceOn
11 Timmons BW, Tamopolsky MA, Snider DP, Bar-Or O. Immunological changes in response to exercise: Influence of age, puberty, and gender. Med Sci Sports Exerc 2006;38:293-304.   DOI   ScienceOn
12 Nielsen AR, Pedersen BK. The biological roles of exerciseinduced cytokines: IL-6, IL-8, and IL-15. Appl Physiol Nutr Metab 2007;32:833-9.   DOI   ScienceOn
13 Pedersen BK, Fischer CP. Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol Sci 2007; 28:152-6.   DOI   ScienceOn
14 Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-7.   DOI   ScienceOn
15 Perrier S, Darakhshan F, Hajduch E. IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde? FEBS Lett 2006;580: 6289-94.
16 Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Timmerman KL, McFarlin BK, Coen PM, Talbert E. The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc 2007;39:1714-9.   DOI   ScienceOn
17 Miles MP. How do we solve the puzzle of unintended consequences of inflammation? Systematically. J Appl Physiol 2008;105: 1023-5.   DOI   ScienceOn
18 Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol 2010;2010:520258.
19 Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Fact Rev 2002;13:323-40.   DOI   ScienceOn
20 Petersen AM, Pedersen BK. Thc anti-inflammatory effect of exercise. J Appl Physiol 2005;98: 1154-62.   DOI   ScienceOn
21 Radom-Aizik S, Leu SY, Cooper DM, Zaldivar F Jr. Serum from exercising humans suppresses t-cell cytokine production. Cytokine 2007;40:75-81.   DOI   ScienceOn
22 Harman E. The biomechanics of resistance exercise. In: Baechle TR, Earle RW editors. Essentials of strength training and conditioning, 2nd ed. Champaign, IL: Human Kinetics; 2000.
23 Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med 2008;38:483-503.   DOI   ScienceOn
24 Amlstrong RB. Initial events in exercise-induced muscular injury. Med Sci Sports Exerc 1990;22:429-35.
25 Cases N, Aguilo A, Tauler P, Sureda A, Llompart I, Pons A, Tur JA. Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation. Eur J Clin Nutr 2005;59:781-8.   DOI   ScienceOn
26 Kenneth M, Travers P, Walport M. Janeway's Immunobiology. Seventh ed. New York: Garland Science, Taylor and Francis Group; 2007.
27 Vassilakopoulos T, Karatza MH, Katsaounou P, Kollintza A, Zakynthinos S, Roussos C. Antioxidants attenuate the plasma cytokine response to exercise in humans. J Appl Physiol 2003;94: 1025-32.
28 Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Wolsk-Pctersen E, Fcbbraio M. The metabolic role of IL-6 produced during exercise: Is IL-6 an exercise factor? Proc Nutr Soc 2004;63:263-7.
29 Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010;411:785-93.   DOI   ScienceOn
30 Bloomer RJ. The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Sports Med 2007;37:519-32.   DOI   ScienceOn
31 Coffey VG, Hawley JA. The molecular bases of training adaptation. Sports Med 2007;37:737-63.   DOI   ScienceOn
32 Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radic Biol Med 2008;44: 126-31.   DOI   ScienceOn
33 Siegrist M. Role of physical activity in the prevention of osteoporosis. Med Monatsschr Pharm 2008;31 :259-64.
34 Johnston AP, De Lisio M, Parise G. Resistance training, sarcopenia, and the mitochondrial theory of aging. Appl Physiol Nutr Metab 2008;33:191-9.   DOI   ScienceOn
35 Calle MC, Fernandez ML, Kraemer WJ, Volk BM, Kupchak B, Volek JS. Resistance training improves the inflammatory response to an acute resistance exercise bout in healthy young adults. FASEB J 2010;24:743.2.
36 Wynn TA. IL-13 effector functions. Annu Rev Immunol 2003:21; 425-56.   DOI   ScienceOn
37 Kirwan JP, Del Aguila LF. Insulin signalling, exercise and cellular integrity. Biochem Soc Trans 2003;31:1281-5.   DOI   ScienceOn
38 Smith LL, Anwar A, Fragen M, Rananto C, Johnson R, Holbert D. Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol 2000;82: 61-7.   DOI   ScienceOn
39 Robert Harris GO. Neuromuscular anatomy and adaptations to conditioning. In: Baechle TR, Earle RW, editors. Essentials of strength training and conditioning. Champaign, IL: Human Kinetics; 2000.
40 Prokopchuk O, Liu Y, Wang L, Wirth K, Schmidtbleicher D, Steinacker JM. Skeletal muscle IL-4, IL-4Ralpha, IL-13 and IL-I3Ralphal expression and response to strength training. Exerc Immunol Rev 2007;13:67-75.
41 Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans 2007;35:1295-7.   DOI   ScienceOn
42 Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun 2004;320: 449-54.   DOI   ScienceOn
43 Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB. Physical activity, exercise, and inflammatory markers in older adults: Findings from the health, aging and body composition study. J Am Geriatr Soc 2004;52:1098-104.   DOI   ScienceOn
44 Palmer DC, Restifo NP. Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Trends Immunol 2009;30:592-602.   DOI   ScienceOn
45 Sakurai T, lzawa T, Kizaki T, Ogasawara JE, Shirato K, lmaizumi K, Takahashi K, Ishida H, Ohno H. Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. Biochem Biophys Res Commun 2009;379:605-9.   DOI   ScienceOn
46 Gleeson M. Immune function in sport and exercise. J Appl Physiol 2007;103:693-9.   DOI   ScienceOn
47 Cooper DM, Radom.Aizik S, Schwindt C, Zaldivar F Jr. Dangerous exercise: lessons learned from dysrcgulated inflammatory responses to physical activity. J Appl Physiol 2007;103:700-9.   DOI   ScienceOn
48 Pedersen BK, Steensberg A, Keller P, Keller C, Fischer C, Hiscock N, van Hall G, Plomgaard P, Febbraio MA. Musclederived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects. Pflugers Arch 2003;446:9-16.
49 Mathur N, Pedersen BK. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008;2008: 109502.
50 Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2007;4:19-27.
51 Ploeger HE, Takken T, de Greef MH, Timmons BW. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev 2009;15:6-41.
52 Koopman R, Manders RJ, Zorenc AH, Hul GB, Kuipers H, Keizer HA, van Loon LJ. A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol 2005;94:180-7.   DOI   ScienceOn
53 Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A, Jaffey J. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007;147:357-69.   DOI   ScienceOn
54 Levinger I, Goodman C, Peake J, Gamham A, Hare DL, Jerums G, Selig S. Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabet Med 2009;26: 220-7.   DOI   ScienceOn
55 Peake JM, Nosaka K, Muthalib M, Suzuki K. Systemic inflammatory responses to maximal versus subrnaximal lengthening contractions of the elbow flexors. Exerc Immunol Rev 2006;12: 72-85.
56 de Salles BF, Simao R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E. Effects of resistance training on cytokines. Int J Sports Med 2010;31:441-50.   DOI   ScienceOn
57 Kraemer WJ, Ratamess NA. Fundamentals of resistance training: progression and exercise prescription. Med Sci Sports Exerc 2004;36:674-88.   DOI   ScienceOn
58 Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12.
59 Izeboud CA, Monshouwer M, Van Miert AS, Witkamp RF. The $\beta$-adrenoceptor agonist cIenbuterol is a potent inhibitor of the LPS-induced production of TNF-$\alpha$ and IL-6 in vitro and in vivo. Inflamm Res 1999;48:497-502.   DOI   ScienceOn
60 Boyle JP, Honeycutt AA, Narayan KM, Hoerger TJ, Geiss LS, Chen H, Thompson TJ. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 2001;24:1936-40.   DOI   ScienceOn
61 Krook A, Long YC, Zierath JR. Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes. Expert Rev Endocrinol Metab 2007;2:477-85.   DOI   ScienceOn
62 Nieman DC, Davis JM, Brown VA, Henson DA, Dumke CL, Utter AC, Vinci DM, Downs MF, Smith JC, Carson J, Brown A, McAnulty SR, McAnulty LS. Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training. J Appl Physiol 2004;96:1292-8.   DOI   ScienceOn
63 Horsley V, Jansen KM, Mills ST, Pavlath GK. IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 2003;113:483-94.   DOI   ScienceOn
64 MacIntyre DL, Sorichter S, Mair J, Berg A, McKenzie DC. Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. Eur J Appl Physiol 2001 ;84:180-6.   DOI   ScienceOn
65 Buford TW, Cooke MB, Willoughby DS. Resistance exerciseinduced changes of inflammatory gene expression within human skeletal muscle. Eur J Appl Physiol 2009;107:463-71.   DOI   ScienceOn
66 Peake JM, Suzuki K, Hordem M, Wilson G, Nosaka K, Coombes JS. Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 2005;95:514-21.   DOI
67 Gokhalc R, Chandrashekara S, Vasanthakumar KC. Cytokine response to strenuous exercise in athletes and non-athletes-an adaptive response. Cytokine 2007;40:123-7.   DOI   ScienceOn
68 Nielsen AR, Mounier R, Plomgaard P, Mortensen OH, Penkowa M, Speerschneider T, Pilegaard H, Pedersen BK. Expression of interleukin-15 in human skeletal muscle - effect of exercise and muscle fibre type composition. J Physiol 2007;584:305-12.   DOI   ScienceOn
69 Phillips MD, Mitchell JB, Currie-Elolf LM, Yellott RC, Hubing KA. Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity. J Strength Cond Res 2010;24:1091-101.   DOI   ScienceOn
70 Uchida MC, Nosaka K, Ugrinowitsch C, Yamashita A, Martins E Jr, Moriscot AS, Aoki MS. Effect of bench press exercise intensity on muscle soreness and inflammatory mediators. J Sports Sci 2009;27:499-507.   DOI   ScienceOn
71 Pedersen BK, Febbraio MA. Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiol Rev 2008;88: 1379-406.   DOI   ScienceOn
72 Rieusset J, Bouzakri K, Chevillotte E, Ricard N, Jacquet D, Bastard JP, Laville M, Vidal H. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Diabetes 2004;53:2232-41.   DOI   ScienceOn
73 Fox CS, Coady S, Sorlie PD, Levy D, Meigs JB, D'Agostino Sr RB, Wilson PWF, Savage PJ. Trends in cardiovascular complications of diabetes. JAMA 2004;292:2495-9.   DOI   ScienceOn
74 Izquierdo M, Ibanez J, Calbet JAL, Navarro-Amezqueta I, Gonzalez-Izal M, Idoate F, Hakkinen K, Kraemer WJ, Palacios-Sarrasqueta M, Almar M, Gorostiaga EM. Cytokine and hormone responses to resistance training. Eur J Appl Physiol 2009; 107:397-409.   DOI   ScienceOn
75 Pedersen BK, Febbraio M. Muscle-derived interleukin-6--a possible link between skeletal muscle, adipose tissue, liver, and brain. Brain Behav Immun 2005;19:371-6.   DOI   ScienceOn
76 Smith C, Kruger MJ, Smith RM, Myburgh KH. The inflammatory response to skeletal muscle injury: Illuminating complexities. Sports Med 2008;38:947-69.   DOI   ScienceOn
77 Pedersen BK, Akerstrom TCA, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol 2007; 103: 1093-8.   DOI   ScienceOn
78 Hirose L, Nosaka K, Newton M, Laveder A, Kano M, Peake J, Suzuki K. Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev 2004;10: 75-90.
79 Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002;2:410-6.
80 Cannon JG, St. Pierre BA. Cytokines in exertion-induced skeletal muscle injury. Mol Cell Biochem 1998;179:159-67.   DOI   ScienceOn