[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4162/nrp.2009.3.4.323

Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia

Hong, Hee-Ok (Department of Food Service Management and Nutrition, Sangmyung University)
Kim, Chun-Soo (Department of Food and Nutrition, Chung-Ang University)
Maeng, Sung-Ho (Maria Biotech Co.)

Publication Information

Nutrition Research and Practice / v.3, no.4, 2009 , pp. 323-327 More about this Journal

Abstract

This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia. For this purpose, a randomized, double-blind, placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8. Subjects received either sweet potato starch (group A, placebo, 320 mg/day), pumpkin seed oil (group B, 320 mg/day), saw palmetto oil (group C, 320 mg/day) or pumpkin seed oil plus saw palmetto oil (group D, each 320 mg/day). International prostate symptom score, quality of life, serum prostate specific antigen, prostate volume and maximal urinary flow rate were measured. In groups B, C and D, the international prostate symptom score were reduced by 3 months. Quality of life score was improved after 6 months in group D, while those of groups B and C were improved after 3 months, compared to the baseline value. Serum prostate specific antigen was reduced only in group D after 3 months, but no difference was observed in prostate volume in all treatment groups. Maximal urinary flow rate were gradually improved in groups B and C, with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil. From these results, it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinically safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.

Keywords

Symptomatic benign prostatic hyperplasia; pumpkin seed oil; saw palmetto oil; International prostate symptom score;

Citations & Related Records

Times Cited By KSCI : 3 (Citation Analysis)
Times Cited By Web Of Science : 0 (Related Records In Web of Science)

Reference
Cited By KSCI

1	Hirsch IH (2000). Integrative urology: a spectrum of complementary and alternative therapy. Urology 56:185-189 DOI ScienceOn
2	Lee S, Min HG, Choi SH, Kim YJ, Oh SW, Park Y & Kim SS (2006). Central obesity as a risk factor for prostatic hyperplasia. Obesity (Silver Spring) 14:172-179 DOI
3	Mehrabi S, Shirazi HG, Rastim M & Bayat B (2005). Analysis of serum prostate-specific antigen levels in men aged 40 years and older in yasuj, Iran. Urol J 2:189-192
4	Nickel JC (1998). Placebo therapy of benign prostatic hyperplasia: a 25-month study. Canadian PROSPECT Study Group. Br J Urol 81:383-387 DOI
5	Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW & Sun SZ (2008). Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. J Med Food 11:207-214 DOI ScienceOn
6	Tsai YS, Tong YC, Cheng JT, Lee CH, Yang FS & Lee HY (2006). Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats. Urol Int 77:269-274 DOI ScienceOn
7	Ernst E (2002). The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med 136:42-53 DOI ScienceOn
8	Moon YT, Oh CH & Kim SC (1990). Clinical effect of Sitosterol ( $Pronal^{R}$ ) on the treatment of benign prostatic hypertrophy. Korean Journal of Andrology 8:23-29
9	Pathak SK, Sharma RA & Mellon JK (2003). Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review). Int J Oncol 22:5-13
10	Carbin BE, Larsson B & Lindahl O (1990). Treatment of benign prostatic hyperplasia with phytosterols. Br J Urol 66:639-641 DOI ScienceOn
11	Kondas J, Philipp V & Dioszeghy G (1996). Sabal serrulata extract (Strogen forte) in the treatment of symptomatic benign prostatic hyperplasia. Int Urol Nephrol 28:767-772 DOI
12	Weisser H, Tunn S, Behnke B & Krieg M (1996). Effects of the Sabal serrulata extract IDS 89 and its subfraction on 5 alpha-reductase activity in human benign prostatic hyperplasia. Prostate 28:300-306 DOI ScienceOn
13	Watson V, Ryan M, Brown CT, Barnett G, Ellis BW & Emberton M (2004). Eliciting preferences for drug treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. J Urol 172:2321-2325 DOI ScienceOn
14	Barry MJ, Fowler FJ Jr., Bin L, Pitts JC 3rd, Harris CJ & Mulley AG Jr. (1997). The natural history of patients with benign prostatic hyperplasia as diagnosed by North American urologists. J Urol 157:10-14 DOI
15	Braeckman J (1994). The extract of serenoa repens in the treatment of benign prostatic hyperplasia: A multicenter open study. Curr Ther Res 55:776-785 DOI ScienceOn
16	Willetts KE, Clements MS, Champion S, Ehsman S & Eden JA (2003). Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial. BJU Int 92:267-270 DOI ScienceOn
17	Breu W, Hagenlocher M, Redl K, Tittel G, Stadler F & Wagner H (1992). Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism. Arzneimittelforschung 42:547-551
18	Ortiz MV (1998). Alternative medicine: Incorporation into therapeutics topics. Am J Pharm Educ 62:208-212
19	Preuss HG, Marcusen C, Regan J, Klimberg IW, Welebir TA & Jones WA (2001). Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol 33:217-225 DOI ScienceOn
20	Di Silverio F, D'Eramo G, Lubrano C, Flammia GP, Sciarra A, Palma E, Caponera M & Sciarra F (1992). Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 21:309-314 DOI
21	Lee DH, Yang WJ, Chung BH, Kim SI, Kim SJ & Kim HS (2005). A multicenter study of the detection rate for prostate cancer according to the serum prostate specific antigen level in Korean men. Korean Journal of Urology 46:433-437
22	Buck AC (2004). Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Urol 172:1792-1799 DOI ScienceOn
23	Shoskes DA (2002). Phytotherapy in chronic prostatitis. Urology 60:35-37 DOI ScienceOn
24	Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J & Mulrow C (1998). Saw Palmetto extracts for treatment of benign prostatic hyperplasia. JAMA 280:1604-1609 DOI ScienceOn
25	Bach D (2000). Placebo-controlled, long-term therapeutic study of a pumpkin seed extract product in patients with micturition complaints from benign prostatic hyperplasia. Urologe B 40:437-443 DOI ScienceOn
26	Carraro JC, Raynaud JP, Koch G, Chisholm GD, Di Silverio F, Teillac P, Da Silva FC, Cauquil J, Chopin DK, Hamdy FC, Hanus M, Hauri D, Kalinteris A, Marencak J, Perier A & Perrin P (1996). Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 29:231-240 DOI ScienceOn
27	Debruyne F, Koch G, Boyle P, Da Silva FC, Gillenwater JG, Hamdy FC, Perrin P, Teillac P, Vela-Navarrete R & Raynaud JP (2002). Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study. Eur Urol 41:497-506 DOI ScienceOn
28	Hisashi H, Masahiro N, Yoshifumi S, Kenichi T, Hiroshi K & Tsuneharu M (2005). Prevalence of lower urinary tract symptoms and seeking acupuncture treatment in men and women aged years or older: A community-based epidemiological study in Japan. Japanese Acupuncture and Moxibustion 1:27-35
29	Cristoni A, Di Pierro F & Bombardelli E (2000). Botanical derivatives for the prostate. Fitoterapia 71:S21-28 DOI ScienceOn
30	Vickers A (2000). Recent advances: complementary medicine. BMJ 321:683-686 DOI
31	Melo EA, Bertero EB, Rios LA & Mattos D Jr. (2002). Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial. Int Braz J Urol 28:418-425
32	Wilt TJ, MacDonald R & Ishani A (1999). beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 83:976-983
33	Gossell-Williams M, Davis A & O'Connor N (2006). Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. J Med Food 9:284-286 DOI ScienceOn
34	Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA & deKernion JB (2000). Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 163:1451-1456 DOI ScienceOn
35	Singh YN, Devkota AK, Sneeden DC, Singh KK & Halaweish F (2007). Hepatotoxicity potential of saw palmetto (Serenoa repens) in rats. Phytomedicine 14:204-208 DOI ScienceOn
36	Cho JS, Kim CI, Seong DH, Kim HS, Kim YS & Kim SJ (2005). Relationship between serum prostate specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study. Korean Journal of Urology 46:792-798
37	Wilt TJ, Ishani A, Rutks I & MacDonald R (2000). Phytotherapy for benign prostatic hyperplasia. Public Health Nutr 3:459-472 DOI ScienceOn

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2	(2011) Phytotherapy Research Androgen-independent Effects of Serenoa repens Extract (Prostasan®) on Prostatic Epithelial Cell Proliferation and Inflammation / 26 (2) , 259
3	(2013) Mediterranean Journal of Nutrition and Metabolism Pumpkin (Cucurbita sp.) seeds as nutraceutic: a review on status quo and scopes / 6 (3) , 183
1741-4288	(2014) Evidence-Based Complementary and Alternative Medicine Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial / 2014 (1741-4288) , 1
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3	(2014) Therapeutic Advances in Urology A green and black tea extract benefits urological health in men with lower urinary tract symptoms / 6 (3) , 89
1525-6103	(2018) Food Reviews International L.) seed oil for health condition of men / (1525-6103) , 1
4	(2009) Food chemistry Extraction, isolation and characterisation of oil bodies from pumpkin seeds for therapeutic use / 134 (4) , 1919
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None	(2009) Research and reports in urology Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis / 10 (None) , 95
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12	(2009) Pharmaceutics Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation / 11 (12) , 640
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5	(2021) Investigative and clinical urology <I>Serenoa repens</I> for the treatment of lower urinary tract symptoms due to benign prostatic enlargement: A systematic review and meta-analysis / 62 (5) , 520
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3	(2009) Wiener klinische Wochenschrift A glimpse into the efficacy of alternative therapies in the management of benign prostatic hyperplasia / 133 (3) , 153
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3	(2009) Comprehensive reviews in food science and food safety Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review / 20 (3) , 2382
9	(2021) Journal of cosmetic dermatology : the official journal of the European Society for Cosmetic & Aesthetic Dermatology Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial / 20 (9) , 2867
10	(2009) Journal of medicinal food Pumpkin Seed Extracts Inhibit Proliferation and Induce Autophagy in PC-3 Androgen Insensitive Prostate Cancer Cells / 24 (10) , 1076
23	(2009) Molecules Treatment of Benign Prostatic Hyperplasia by Natural Drugs / 26 (23) , 7141
1	(2009) Phytomedicine plus A systematic review of herbal medicine in the clinical treatment of benign prostatic hyperplasia / 2 (1) , 100153