Browse > Article

Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats  

Nam, Jeong-Su (Dept of Biomedical Laboratory Science, Center of Smart Foods and Drugs, Inje University)
Choi, Hyun-Ju (Dept of Biomedical Laboratory Science, Center of Smart Foods and Drugs, Inje University)
Publication Information
Nutrition Research and Practice / v.2, no.4, 2008 , pp. 240-246 More about this Journal
Abstract
Cassia tora L. seeds have previously been reported to reduce blood glucose level in human and animals with diabetes. In the present study, the effects of Cassia tora L. seed butanol fraction (CATO) were studied on postprandial glucose control and insulin secretion from the pancreas of the normal and diabetic rats. Diabetes was induced by an i.p. injection of Streptozotocin (55 mg/kg BW) into the male Sprague-Dawley rats. The postprandial glucose control was monitored during a 240 min-period using a maltose loading test. In normal rats, rats fed CATO (20 mg/l00 g BW/d) showed lower postprandial glucose levels in all the levels from 30 min up to 180 min than those in the control rats without CATO (p<0.05). In diabetic rats, those levels in the CATO group seemed to be lower during the $30{\sim}180$ min, but only glucose level at 30 min showed significant difference compared to that in the control group. Moreover, CATO delayed the peak time of the glucose rise in both normal and diabetic rats in the glucose curves. On the other hand, when CATO was administered orally to the diabetic rats for 5 days, 12 hr fasting serum glucose level was decreased in the diabetic rats (p<0.05). Degree of a decrease in 12 hr fasting serum insulin levels was significantly less in the diabetic CATO rats as compared to diabetic control rats. On the last day of feeding, P cells of the pancreas were stimulated by 200 mg/dL glucose through a 40 min-pancreas perfusion. Amounts of the insulin secreted from the pancreas during the first phase ($11{\sim}20$ min) and the second phase ($21{\sim}40$ min) in the CATO fed diabetic rats were significantly greater than those in the diabetic control group (p<0.05). These findings indicated that constituents of Cassia tora L. seeds have beneficial effect on postprandial blood glucose control which may be partially mediated by stimulated insulin secretion from the pancreas of the diabetic rats.
Keywords
Diabetes; Cassia tora L. seeds butanol fraction; pancreas perfusion; insulin secretion;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Rossetti L, Giaccari A & DeFronzo RA (1990). Glucose toxicity. Diabetes Care 13:610-630   DOI   ScienceOn
2 Strandgaard C & Curry DL (1998). Differential insulin secretory responses to cationic and branched-chain amino acids. Pancreas 17:65-71   DOI   ScienceOn
3 Ahren B, Taborsky Jr GJ (1986). The mechanism of vagal nerve stimulation of glucagon and insulin secretion in the dog. Endocrinology 118:1551-1556   DOI   ScienceOn
4 Curry DL, Morris JG & Rogers QR (1982). Dynamics of insulin and glucagon secretion by the isolated perfused cat pancreas. Comp Biochem Physiol 72:333-338   DOI   ScienceOn
5 Choi JS, Lee HJ & Lang SS (1994). Alaternin, cassiaside and rubrofusarin-gentibiodise, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picryhydrazyl (DPPH) radical. Arch Pharm Res 17:462-466   DOI
6 Choi HJ (2000). Effects of cephalic glucopenia on insulin and glucagons secretion in central nervous system-intact pancreas perfused rats. 2000 Korean Journal of Biomedical Laboratory 6:229-235
7 Curry DL (1984). Reflex inhibition of insulin secretion: vagus nerve involvement via CNS. Am J Phsiol 247:E827-E832
8 Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M & White MF (2003). Upregulation of insulin receptor substrate-2 in pancreatic ${\beta}$ cells prevents diabetes. J Clin Invest 112:1521-1532   DOI
9 Kim SH, Choi JS & Moon YH (1998). Antioxidative activity and anticlastogenicity of Cassia tora L. seeds extract and its major component, $nor-rubrofusarin-6-{\beta}-D-glucoside$. Journal of Food Hygiene and Safety 13:394-399
10 Na GM, Han HS, Ye SH & Kim HK (2004). Extraction characteristics and antioxidative activity of Cassia tora L. extracts. Korean Journal of Food Culture 19:499-505
11 Park SH & Wang SG (2008). A research on anti-diabetic functional food intake of the subjects with type 2 diabetic mellitus in Daejeon. Korean Journal of Human Ecology 17:797-805   DOI
12 Porksen N, Hollingdal M, Juhl C, Butler P, Veldhuis, JD & Schmitz O (2002). Pulsatile insulin secretion: detection, regulation, and role in diabetes. Diabetes 51:S245-S254   DOI
13 Baly DL, Curry DL, Keen CL & Hurley LS (1984). Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats. J Nutr 114:1438-1446   DOI
14 Lee JR (2008). Inquiry into the insulin injection. Korean Clinical Diabetes 9:117-122
15 Kim JM, Kim HT & Hwang SM (1990). Instant tea preparation from Cassia tora Seeds. Korean Journal of Food Science and Technology 22:241-247
16 Ahren B, Veith RC & Taborshy Jr GJ (1987). Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: effects on basal release of insulin and glucagon. Endocrinology 121:323-331   DOI   ScienceOn
17 Kim YS, Chun JH, Park JH & Kang CI (2000). Status and associating factors of complementary and alternative medicine among Korean diabetic patients. The Journal of Korean Diabetes Association 24:7-89
18 Adisakwattana S, Moonsan P & Yibchok-anun S (2008). Insulinreleasing properties of a series of cinnamic acid derivatives in vitro and in vivo. J Agric Food Chem 56:7838-7844   DOI   ScienceOn
19 Brockman RP (1982). Insulin and glucagon responses in plasma to intraportal infusions of propionate and butyrate in sheep (Ovia aries). Comp Biochem Physiol 73:237-238   DOI   ScienceOn
20 Curry DL (1986). Insulin content and insulinogenesis by the perfused rat pancreas: effects of long term glucose stimulation. Endocrinology 118:170-175   DOI   ScienceOn
21 Curry DL (1983). Direct tonic inhibition of insulin secretion by central nervous system. Am J Physiol 244:E425-E429
22 Curry DL, Joy RM & Bennett LL (1977). Magnesium modulation of glucose-induced insulin secretion by the perfused rat pancreas. Endocrinology 101:203-208   DOI   ScienceOn
23 Yki-Jarvinen H (1992). Glucose toxicity. Endocr Rev 13:415-431
24 Nolan CJ, Madiraju MSR, Delghingaro-Augusto V, Peyot M & Prentki M (2006). Fatty Acid Signaling in the ${\beta}-cell$ and Insulin Secretion. Diabetes 55:S16-S23   DOI
25 Weir GC & Bonner-Weir S (2004). Five Stages of Evolving ${\beta}-Cell$ Dysfunction During Progression to Diabetes. Diabetes 53:S16-S21   DOI   ScienceOn
26 Yen GC, Chen HW & Duh PD (1998). Extraction and identification of an antioxidative component from Jue Ming Zi (Cassia tora L.). J Agric Food Chem 46:820-824   DOI   ScienceOn
27 Choi JS, Lee HJ, Ha JO, Park KY & Kang SS (1997). In vitro antimutagenic effects of anthraquinone alycones and naphthopyrone glycodises from Cassia tora. Planta Med 63:11-14   DOI   ScienceOn
28 Hsu JH, Wu YC, Liu IM & Cheng JT (2006). Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus offcinalis. Neurosci Lett 404:112-116   DOI   ScienceOn
29 Ahn DK (1998). Illustrated book of Korean medicinal herbs, p.636. Kyo-Hak Publishing Co., Ltd, Seoul. Republic of Korea
30 Choi HJ (1997). Calcium modulation of insulin secretion in perfused pancreata of obese Zucker rats. J Food Sci Nutr 2:144-148   과학기술학회마을
31 Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL & Kim JS (2007). Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol Pharm Bull 30:2207-2210   DOI   ScienceOn
32 Lim SJ, Kim SY & Lee JW (1995). The effects of Korean wild vegetables on blood glucose levels and liver muscle metabolism of streptozotocin-induced diabetic rats. The Korean Journal of Nutrition 28:585-594
33 Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J & Herold KC (2004). Insulin secretion in type 1 diabetes. Diabetes 53:426-433   DOI   ScienceOn
34 Gorsuch AN, Spencer KM, Lister JM, McNally JM, Dean BM, Bottazzo GF & Cudworth AG (1981). Evidence for a long prediabetic period in type I (insulin dependent) diabetes mellitus. Lancet 2:1363-1365
35 Lim SJ & Han HK (1997). Hypoglycemic effect of fractions of Cassia tora extract in Streptozotocin-induced diabetic Rats. Journal of the Korean Society of Food Science and Nutrition 13:23-29
36 Curry DL & Maclachlan SA (1987). Synthesis-secretion coupling of insulin: effect of aging. Endocrinology 121:241-247   DOI   ScienceOn
37 Park KJ, Oh YJ, Lee SY, Kim HS & Ha HC (2007). Anti-diabetic effect of crude polysaccharides from Grifola frondosa in $KK-A^y$ diabetic mouse and 3T3-L1 adipocyte. Korean Journal of Food Science and Technology 39:330-335   과학기술학회마을
38 Yibchok-anun S, Adisakwattana A, Moonsan P & Hsu WH (2008). Insulin-secretagogue activity of p-Methoxycinnamic acid in rats, perfused rat pancreas and pancreatic ${\beta}-Cell$ line. Basic Clin Pharmacol Toxicol 102:476-482   DOI   ScienceOn
39 Kim SH, Ryu DS, Lee MY, Kim KH, Kim YH & Lee DS (2008). Anti-diabetic activity of polysaccharide from Salicornia herbacea. Korean Journal of Microbiology and Biotechnology 36:43-48   과학기술학회마을
40 Kim SJ, Baek SH, Heo JW, Kim US, Lee JD, Kang GW, Park SH, Han JH, Jeong SY & Lee SH (2002). Effect of Cassia tora L. powder aged-diets on the accumulation of cadmium in rat. Journal of East Asian Society of Dietary Life 12:554-565
41 Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G & White MF (2006). Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic ${\beta}-Cell$ Growth and Function. J Biol Chem 281:1159-1168   DOI   ScienceOn
42 Lee HC, Curry DL & Stern JS (1989). Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve. Am J Physiol 256:E439-E444
43 Lee HC, Curry DL & Stern JS (1993). Tonic sympathetic nervous system inhibition of insulin is diminished in obese Zucker rats. Obes Res 1:371-376   DOI   ScienceOn