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Combined Effects of Cell Cultured Acanthopanax Senticosus Supplementation and Exercise on Lipid Profiles, Carnitine and Leptin Levels in Mice  

Koo, Bon-Sun (Research Institute Center of Bioactive Material, Chonbuk National University)
Soh, Ju-Ryoun (Department of Food Science and Human Nutrition, Human Nutrition & Research Institute of Human Ecology, Chonbuk National University)
Cha, Youn-Soo (Department of Food Science and Human Nutrition, Human Nutrition & Research Institute of Human Ecology, Chonbuk National University)
Publication Information
Nutritional Sciences / v.9, no.4, 2006 , pp. 273-279 More about this Journal
Abstract
The purpose of this study was to determine the independent and the combined effects of cell cultured Acanthopanax senticosus extracts (ASE) supplementation and swimming exercise on body weight, lipid profile, carnitine and leptin levels in C57 BL/6J mice. Forty C57BL/6J mice were divided into four groups: non-supplement and non-exercise (NSNE); non-supplement and exercise (NSE); supplement and non-exercise (SNE); supplement and exercise (SE) mice. They were allowed free access to food and water. The exercised groups were forced to swim (1hr, 6 days a week) in a water bath for 12 weeks. The supplemented groups were fed Cell cultured ASE (0.5 g/kg body weight/day) for 12 weeks. In this study, we found that the combination of Cell cultured ASE supplementation and exercise significantly decreased liver triglyceride (TG) level and serum leptin level but significantly increased serum HDL-cholesterol level compare to control (NSNE) group. These improved lipid profiles and decreased serum leptin would have positive effects on obesity and cardiovascular disease.
Keywords
Acanthopanax senticosus; LDL-cholesterol; HDL-cholesterol; Leptin; Cardiovascular disease;
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1 Hibasami H, Fujikawa T, Takeda H, Nishibe S, Satoh T, Fujisawa T, Nakashima K. Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncol Rep 7:1213-1216, 2000
2 Gaffney BT, Hugel HM, Rich PA. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes, Life Sci 70:431-442, 2001   DOI   ScienceOn
3 Wagner H, Norr H, Winterhoff H. Plant adaptogens. Phytomedicine 1:63-76, 1994   DOI
4 Beltowski J. Leptin and atherosclerosis. Atherosclerosis 18:947-60, 2006
5 Zhang Y, Scarpace PJ. The role of leptin in leptin resistance and obesity. Physiol Behav 88:249-256, 2006   DOI   ScienceOn
6 van der Vleuten GM, Veerkamp MJ, van Tits LJ, Toenhake H, den Heijer M, Stalenhoef AF, de Graaf J. Elevated leptin levels in subjects with familial combined hyperlipidemia are associated with the increased risk for CVD. Atherosclerosis 183:355-360, 2005   DOI   ScienceOn
7 Cederblad G, Lindstedt S. A method for the determination of carnitine in the picomole range. Clin Chim Acta 37:235343, 1972
8 Sachan DS, Rhew TH, Ruak RS. Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver. Am J Clin Nutr 123:1939-1951, 1984
9 Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, Sattar N. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104:3052-3056, 2001   DOI   ScienceOn
10 Shadid S, LaForge R, Otvos JD, Jensen MD. Treatment of obesity with diet/exercise versus pioglitazone has distinct effects on lipoprotein particle size. Atherosclerosis 188(2):370-376, 2006   DOI   ScienceOn
11 Cha YS, Rhee SJ, Heo YR. Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL/6J Mice Fed a High Fat Diet. J Med Food 7:422-429, 2004   DOI   ScienceOn
12 Szolomicki J, Samochowiec L, Wojcicki J, Drozdzik M, Szolomicki S. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother Res 14:30-35, 2000   DOI   ScienceOn
13 Glatthaar-Saalmuller B, Sacher F, Esperester A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res 50:223-228, 2001   DOI   ScienceOn
14 Crill CM, Storm MC, Christensen ML, Hankins CT, Bruce JM, Helms RA. Carnitine supplementation in premature neonates: Effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Clin Nutr (In press), 2006
15 Rebuzzi A, Schiavoni G, Amico C. Beneficial effects of L-carnitine in the reduction of the necrotic area in acute myocardial infarction. Drugs Exptl Clin Res 10:219-223, 1984
16 Durstine J, Grandjean P, Davis P. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med 31:1033-1062, 2001   DOI   ScienceOn
17 Folch J, Lees M, Sloane-Stanley GHS. Simple method of the isolation of total lipids from animal tissues. J biol Chem 22:497-509, 1983
18 Barter PJ, Rye KA. High density lipoproteins and coronary heart disease. Atherosclerosis 121:1-12, 1996   DOI   ScienceOn
19 Calo LA, Pagnin E, Davis PA, Semplicini A, Nicolai R, Calvani M, Pessina AC. Antioxidant effect of L-carnitine and its short chain esters Relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 107:54-60, 2006   DOI   ScienceOn
20 Schafer K, Halle M, Goeschen C, Dellas C, Pynn M, Loskutoff DJ, Konstantinides S. Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Bio 24:112-117, 2004   DOI   ScienceOn
21 Kelley GA, Kelly KS. Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trials. jmhg 3:61-70, 2006
22 Leibovitz BE. L-Carnitine the energy nutrient. In: Physical performance, pp.30-32, Kets Publishing, Los Angeles, 1998
23 Rainwater DL, Comuzzie AG, Vandeberg JL, Mahaney MC, Blangero J. Serum leptin levels are independently correlated with two measures of HDL. Atherosclerosis 132:237-243, 1997   DOI   ScienceOn
24 Lin CC, Huang PC. Antioxidant and hepatoprotective effects of Acanthopanx sentocosus. Phytother Res 14:489-494, 2000   DOI   ScienceOn
25 Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as a risk factors for clinical diabetes in man. Diabetes Care 17:961-969, 1994   DOI   ScienceOn
26 O' Rourke L, Yeaman SJ, Shepherd PR. Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. Diabetes 50:955-961, 2001   DOI
27 Freidwald WT, Levy RL, Fredrickso DS. Estimation of the concentration of low density lipoprotein cholesterol without use of the preparation ultracentrifuge. Clin Chem 18:499-502, 1972
28 Peluso G, Barbarisi A, Savica V. Carnitine: an osmolyte that plays a metabolic role. J cell Biochem 80:1-10, 2001   DOI   ScienceOn
29 Ozcelik O, Dogan H, Kelestimur H. Effects of eight weeks of exercise training and orlistat therapy on body composition and maximal exercise capacity in obese females. Public Health 120:76-82, 2006   DOI   ScienceOn
30 Reznick AZ, Kagan VE, Ramsey R. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. Arch Biochem Biophys 296:394-401, 1992   DOI   ScienceOn
31 Durstine J, Grandjean P, Cox C. Lipids, lipoproteins, and exercise. J Cardiopulm Rehabil 22:385-397, 2002   DOI   ScienceOn