Browse > Article

Effect of Platycodon Grandiflorum Aqueous Extract on Lipid Levels in Rats  

Kim Jeong-Seon (Department of Oriental Medical Food & Nutrition, Semyung University)
Publication Information
Nutritional Sciences / v.9, no.3, 2006 , pp. 167-172 More about this Journal
Abstract
This study investigated the effects of Platycodon grandiflorum aqueous extract on lipid concentration of serum and liver in rats fed high cholesterol diet Male Sprague-Dawley rats were assigned to three groups (control, low dose of extract, high dose of extract) for four weeks. The serum total cholesterol concentration was significantly lower in the low and high doses of extract groups than in the control group. There was a significant decrease in the free cholesterol, cholesterol ester, LDL-cholesterol, and triglycerides concentrations in serum, and the total cholesterol and the triglycerides contentin liver in the low and high doses of extract groups compared to the control group. When the serum phospholipid concentration was compared among the groups, it was significantly lower in high dose of extract group than in control and low dose of extract group. It can be postulated that Platycodon grandiflorum aqueous extract may possess substantial hypolipidemic properties in rats.
Keywords
Platycodon grandiflorum; Lipids; Serum; Liver; Rats;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kritchevsky D, Story JA. Binding of bile salts in vitro by nonnutritive fiber. J Nutr 104:458-462, 1974   DOI
2 Nicoll A, Miller NE, Lewis B. High-density lipoprotein metabolism. Adv Lipid Res 17:53-106, 1980
3 Bell LP, Hectorn KJ, Reynolds H, Hunninghake DB. Cholesterollowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia. Am J Clin Nutr 52:1020-1026, 1950
4 Akiba Y, Matsumoto T. Effects of dietary fibers on lipid metabolism in liver and adipose tissue in chicks. J Nutr 112:1577-1585, 1982   DOI
5 Ershoff BH, Wells AF. Effects of gum guar, locust bean and carrageenan on liver cholesterol of cholesterol-fed rats. Proc Soc Exp Biol Med 110:580-582, 1962
6 Thomas M, Leelamma S, Kurup PA. Effect of blackgram fiber on hepatic hydroxymethylglutaryl-CoA reductase activity, cholesterogenesis and cholesterol degradation in rats. J Nutr 113:1104-1108, 1983   DOI
7 Thomas M, Leelamma S, Kurup PA. Effect of blackgram fiber on hepatic hydroxymethylglutaryl-CoA reductase activity, cholesterogenesis and cholesterol degradation in rats. J Nutr 113:1104-1108, 1983   DOI
8 Garg ML, Thomson AB, Clandinin MT. Effect of dietary cholesterol and/or $\omega$-3 fatty acids on lipid composition and ${\Delta}^5$ -desaturase activity rat liver microsomes. J Nutr 118:661-668, 1988   DOI
9 Ney DM, Lasekan JB, Shinnick FL. Soluble oat fibers tends to normalize lipoprotein composition in cholesterol-fed rats. J Nutr 118:1455-1462, 1988   DOI
10 Saeki T, Koike K, Mikado T. A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis. Planta Med 65:428-431, 1999   DOI   ScienceOn
11 Smith EB. The relationship between plasma and tissue lipid in human atherosclerosis. Adv Lipid Res 12:1-49, 1974
12 Goodman DS. Cholesterol ester metabolism. Physiol Rev 45:747-839, 1965   DOI
13 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in midly hypercholesterolemic men. Am J Clin Nutr 52:661-666, 1990   DOI
14 Shimizu J, Oka M, Kudoh K, Wada M, Takita T, Innami S, Tadokoro T, Maekawa A. Effects of a partially hydrolyzed curdlan on serum and hepatic cholesterol concentration and cereal fermentation in rats. Int J Vitam Nutr Res 72: 101-108, 2002   DOI   ScienceOn
15 Topping DL, Illman RJ, Roach PD, Trimble RP, Kambouris A, Nestel PJ. Modulation of the hypolipidemic effect of fish oils by dietary fiber in rats: Studies with rice and wheat bran. J Nutr 12:325-330, 1990
16 Lee KJ, You HJ, Park SJ, Kim YS, Chung YC, Jeong TC, Jeong HG. Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett 174:73-81, 2001   DOI   ScienceOn
17 Kim KS, Ezaki O, Ikemoto S, Itakura H. Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J Nutr Sci Vitaminol 41:485-491, 1995   DOI   ScienceOn
18 Cillingirouglu M, Ballantyne C. Endothelial lipase and cholesterol metabolism. Curr Atheroscler Rep 6: 126-130, 2004   DOI
19 Bakhsh P, Chughtai MI. Effect of wheat flour, Bengal gram flour and com flour on lipid metabolism in rats. J Nutr Sci Vitaminol 30:297-301, 1984   DOI
20 Han SB, Park SH, Lee KH, Lee CW, Lee SH, Kim HC, Kim YS, Lee HS, Kim MH. Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and rnacrophages but not T cells. Int Immunopharmacol 1:1969-1978, 2004   DOI   ScienceOn
21 Mueller MA, Cleary MP, Kritchevsky D. Influence of dietary fiber on lipid metabolism in meal-fed rats. J Nutr 113:2229-2238, 1983   DOI
22 Malinow MR, Connor WE, McLaughlin P, Stafford C, Lin DS, Livingston AL, Kohler GO, McNulty WP. Cholesterol and bile acid balance in Macaca Fascicularis: Effects of alfalfa saponins. J Clin Invest 67:156-162, 1981   DOI
23 Kesaniemi YA, Tarpila S, Miettinen TA. Low vs high dietary fiber and serum, biliary, and fecal lipids in middle-aged men. Am J Clin Nutr 51:1007-1012, 1990   DOI
24 Nishina PM, Schneeman BO, Freedland RA. Effects of dietary fibers on nonfasting plasma lipoprotein and apolipoprotein levels in rats. J Nutr 121:431-437, 1991   DOI
25 Lee KJ, Choi CY, Chung YC, Kim YS, Ryun SY, Rohm SH, Jung HG. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol Lett 147:271-282, 2004   DOI   ScienceOn
26 Kiriyama S, Okazaki Y, Yoshida A. Hypocholesterolemic effect of polysaccharides and polysaccharide-rich foodstuffs in cholesterol-fed rats. J Nutr 97:382-388, 1969   DOI
27 Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol level. The Framingham Study. JAMA 256:2835-2838, 1986   DOI
28 Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterolemic activity of saponins. Br J Nutr 55:643-649, 1986   DOI   ScienceOn
29 Lipsky H, Gloger M, Frishman WH. Dietary fiber for reducing blood cholesterol. J Clin Pharmacol 30:699-703, 1990   DOI
30 Vahouny GV, Roy T, Gallo LL, Story JA, Kritchevsky D, Cassidy M. Dietary fibers. III. Effects of chronic intake on cholesterol absorption and metabolism in the rat. Am J Clin Nutr 33:2182-2191, 1980   DOI
31 Goldstein JL, Brown MS. The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy. Med Clin North Am 66:335-362, 1983