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Effect of Psyllium Seed Husk on the Postprandial Glucose Control and Insulin Secretion Dynamics

Choi Hyun-Ju (Department of Biomedical Laboratory Science, Biohealth Products Research Center, Food Science Institute, Diet Research Center, Inje University)
Nam Jeong-Su (Department of Biomedical Laboratory Science, Biohealth Products Research Center, Food Science Institute, Diet Research Center, Inje University)

Publication Information

Nutritional Sciences / v.8, no.2, 2005 , pp. 83-88 More about this Journal

Abstract

This study was to investigate the effect of psyllium seed husk (PSYL) on postprandial glucose control and insulin secretion dynamics in Sprague-Dawley rats. In experiment 1, the rise in postprandial serum glucose was monitored during a 240-min period using a maltose loading test In normal rats given 16.6 mg/l00 g B.W./ml of PSYL orally, all the blood glucose levels during the 240-min period did not show statistically significant differences from the corresponding levels in normal rats given water. However, in streptozotocin-induced diabetic rats given the same amount of PSYL, the blood glucose level at 30 min was significantly lower than that in diabetic rats given water, and the peak time of the rise in the postprandial glucose was delayed In experiment 2, the normal (N) and diabetic (Db) rats were given PSYL (25 mg/l00 g B.W./ml/day) orally for 5 days. Blood samples were collected in order to measure the s-glucose and s-insulin levels. The final s-glucose level at day 5 in Db-PSYL was significantly lower than that in the corresponding control rats (Db-CONT) and the final s-insulin level in Db-PSYL was significantly greater than that in Db-CONT. In vitro 40-min pancreas perfusion was performed at day 5 in order to examine the insulin secretion dynamics. Results showed that the amounts of insulin secreted during the first phase (11-20 min) and the second phase (21-40 min) in the Db-PSYL were significantly greater than those in Db-CONT. Therefore, it is concluded that psyllium seed husk could be beneficial for controlling postprandial glucose levels in the stretozotocin-induced diabetic rats, and it may be partially mediated by insulin secretion dynamics.

Keywords

Psyllium seed husk; In vitro pancreas perfusion; Insulin; Postprandial glucose;

Citations & Related Records

Reference

1	Choi HJ. Effect of cephalic glucopenia on insulin and glucagon secretion in central nervous system-intact pancreas perfused rats. Korean J Biomed Lab Sci 6(4):1-7, 2000
2	Brockman RP. Insulin and glucagon responses in plasma to intraportal infusions of propionate and butyrate in sheep (Ovia aries). Comp Biochem Physiol 73(2):237-238, 1982 DOI ScienceOn
3	Anderson JW, Davidson MH, Lawrence B et al., Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am J Clin Nutr 71(6):1433-1438, 2000 DOI
4	Lim DB, Lee YJ. The influence of the herbal compounds of psyllium husk on the body weight and the serum lipid levels of the rats with hypercholesterolemia. Kor J Herbology 16(1):179-188, 2001
5	Hong SS, Cha JY, Kim DJ. Effect of psyllium husk, pectin and cellulose on the lipid concentrations and hemobiochemical enzymes in rats. J Korean Soc Food Sci Nutr 31(5):808-813, 2002 DOI
6	Jenkins DJ, Wolever TM, Leeds AR et al., Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity. Br Med J 27:1(6124):1392-1394, 1978 DOI
7	Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL. Psyllium fiber reduced rise in postprandial glucose and insulin concentrations in patients with non-insulin-dependent diabetes. Am J Clin Nutr 53(6):1431-1435, 1991 DOI
8	Gupta RR, Agrawal CG, Singh GP et al., Lipid-lowering efficacy of psyllium hydrophillic mucilloid in non insulin dependent diabetes mellitus with hyperlipidaemia. Indian J Med Res 100:237-241, 1994
9	Curry DL. Direct tonic inhibition of insulin secretion by central nervous system. Am J Physiol 244 (Endocrinol Metab 7):E425-E429, 1983
10	Ahren B, Taborshy Jr GJ. The mechanism of vagal nerve stimulation of glucagon and insulin secretion in the dog. Endocrinology 118(4):1551-1556, 1986 DOI ScienceOn
11	Ahren B, Veith.RC, Taborshy Jr GJ. Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: effects on basal release of insulin and glucagon. Endocrinology 121(1):323-331, 1987 DOI ScienceOn
12	Lee HC, Curry DL, Stern JS. Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve. Am J Physiol 256 (Endocrinol Metab 19):E439-F444, 1989
13	Miller RE. Pancreatic neuroendocrinology: peripheral neural mechanism in the regulation of the islets of Langerhans. Endocr Rev 2(4):471-494, 1981 DOI PUBMED ScienceOn
14	Moreno LA, Tresaco B, Bueno G et al., Psyllium fibre and the metabolic control of obese children and adolescents. J Physiol Biochem 59(3):235-242, 2003 DOI ScienceOn
15	Choi HJ. Calcium modulation of insulin secretion in perfused pancreata of obese Zucker rats. J Food Sci Nutr 2(2):144-148, 1997
16	Curry DL, Morris JG, Rogers QR. Dynamics of insulin and glucagon secretion by the isolated perfused cat pancreas. Comp Biochem Physiol 72(2):333-338, 1982 DOI ScienceOn
17	Sierra M, Garcia JJ, Fernandez N, Diez MJ, Calle AP. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 56(9):830-842, 2002 DOI ScienceOn
18	Curry DL. Insulin content and insulinogenesis by the perfused rat pancreas: effects of long term glucose stimulation. Endocrinology 118(1):170175, 1986
19	Roberts DC, Truswell AS, Beneke A et al., The cholesterollowering effect of a breakfast cereal containing psyllium fibre. Med J Aust 161 (11-12):660-664, 1994
20	Del Toma E, Lintas C, Clementi A, Marcelli M. Soluble and insoluble dietary fiber in diabetic diets. European J Clin Nutr 42(4):313-319, 1988
21	Watters K, Blaisdell P. Reduction of glycemic and lipid levels in db/db diabetic mice by psyllium plant fiber. Diabetes 38(12):1528-1533, 1989 DOI ScienceOn
22	Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy BP. Effects of psyllium on glucose and serum lipid responses in man with type 2 diabetes and hypercholesterolemia. Am J Clin Nutr 70(4):466-73, 1999 DOI
23	Baly DL, Curry DL, Keen CL, Hurley LS. Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats. J Nutr 114(8):1438-1446, 1984 DOI
24	Vergara-Jimenez M, Conde K, Erickson SK, Fernandez ML. Hypolipidemic mechanism of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. J Lipid Res 33(11):1455-1465, 1998
25	Nuttall FG. Dietary fiber in the management of diabetes. Diabetes 42(4):503-508, 1993 DOI PUBMED ScienceOn
26	Lee HC, Curry DL, Stern JS. Tonic sympathetic nervous system inhibition of insulin is diminished in obese Zucker rats. Obe Res 1(1):371-376, 1993 DOI ScienceOn
27	Frati Munari AC, Benitez Pinto W, Raul Ariza Andrace C et al., Lowering glycemic index of food by acarbose and Plantago psyllium mucilage. Arch Med Res 29(2):137-141, 1998
28	Rodriguez-Moran M, Guerrero-Romero, Lazcano-Burciaga G. Lipid-and glucose-lowering efficacy of Plantago Psyllium in type II diabetes. J Diabetes Complicaitons 12(5):273-278, 1998 DOI ScienceOn
29	Yim MY, Jang SA, Lee SG, Ly SY. Effect of psyllium husk and glucomannan on serum lipids, fecal fat excretion and body fat in rats fed high-fat diet. J Korean Soc Food Sci Nutr 32(3):469-473, 2003 DOI
30	Curry DL, Joy RM, Bennett LL. Magnesium modulation of glucose-induced insulin secretion by the perfused rat pancreas. Endocrinology 101(1):203-208, 1977 DOI ScienceOn
31	Curry DL. and Maclachlan SA. Synthesis-secretion coupling of insulin: effect of aging. Endodrinology 121(1):241-247, 1987 DOI ScienceOn
32	Lee HC, Curry DL, Stern JS. Selective muscarinic sensitivity in perfused pancreata of obese Zucker rats. Intl J Obesity 17(10):569-577, 1993
33	Freeman GL. Plantago ovata(Psyllium). Altern Med Rev 7(2):155-159, 2002
34	Strandgaard C, Curry DL. Differential insulin secretory responses to cationic and branched-chain amino acids. Pancreas 17(1):65-71, 1998 DOI ScienceOn