[KSCI] Korea Science Citation Index Service

Silk Protein as a Fascinating Biomedical Polymer: Structural Fundamentals and Applications

Ki, Chang-Seok (Department of Biosystems and Biomaterials Sciences and Engineering, Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul National University)
Park, Young-Hwan (Department of Biosystems and Biomaterials Sciences and Engineering, Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul National University)
Jin, Hyoung-Joon (Department of Polymer Science and Engineering, Inha University)

Publication Information

Macromolecular Research / v.17, no.12, 2009 , pp. 935-942 More about this Journal

Abstract

Silk is a textile material, as well as one of the oldest biomaterials. However, the recent progress of biomedical science and technology has led to the replacement of silk by various biomaterials based on synthetic polymers. Despite the wide variety of biomaterials available, these materials suffer certain limitations that prevent them from meeting the various demands of the medical field. Therefore, silk continues to attract considerable interest as a promising biomaterial. This paper explains the fundamentals of silk protein, and reviews the many applications of silk biomedical polymers.

Keywords

silk protein; silk fibroin; structure; biomaterial;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)
Times Cited By Web Of Science : 2 (Related Records In Web of Science)
Times Cited By SCOPUS : 5

1	Y. Shen, M. A. Johnson, and D. C. Martin, Macromolecules, 31, 8857 (1998) DOI ScienceOn
2	X. G. Li, L. Y. Wu, M. R. Huang, H. L. Shao, and X. C. Hu, Biopolymers, 89, 497 (2008) DOI ScienceOn
3	C. Holland, A. E. Terry, D. Porter, and F. Vollrath, Nat. Mater., 5, 870 (2006) DOI ScienceOn
4	H. Kweon, H. C. Ha, I. C. Um, and Y. H. Park, J. Appl. Polym. Sci., 80, 928 (2001) DOI ScienceOn
5	B. M. Min, G. Lee, S. H. Kim, Y. S. Nam, T. S. Lee, and W. H. Park, Biomaterials, 25, 1289 (2004) DOI ScienceOn
6	X. Wang, X. Zhang, J. Cstellot, I. Herman, M. Iafrati, and D. L. Kaplan, Biomaterials, 29, 894 (2008) DOI ScienceOn
7	H. J. Kim, U. J. Kim, G. G. Leisk, C. Bayan, I. Georgakoudi, and D. L. Kaplan, Macromol. Biosci., 7, 643 (2007) DOI ScienceOn
8	M. L. Lovett, C. M. Cannizzaro, G. Vunjak-Novakovic, and D. L. Kaplan, Biomaterials, 29, 4650 (2008) DOI ScienceOn
9	X. Zhang, C. B. Baughman, and D. L. Kaplan, Biomaterials, 29, 2217 (2008) DOI ScienceOn
10	B. D. Lawrence, J. K. Marchant, M. A. Pindrus, F. G. Omenetto, and D. L. Kaplan, Biomaterials, 30, 1299 (2009) DOI ScienceOn
11	J. E. Moreau, J. S. Chen, D. S. Bramono, V. Volloch, H. Chernoff, G. Vunjak-Novakovic, J. C. Richmond, D. L. Kaplan, and G. H. Altman, J. Orthop. Res., 23, 164 (2005) DOI ScienceOn
12	H. Oh, J. Y. Lee, A. Kim, C. S. Ki, J. W. Kim, Y. H. Park, and K. H. Lee, Fiber. Polym., 8, 470 (2007) DOI ScienceOn
13	H. J. Jin and D. L. Kaplan, Nature, 424, 1057 (2003) DOI ScienceOn
14	G. H. Altman, F. Diaz, C. Jakuba, T. Calabro, R. L. Horan, J. S. Chen, H. Lu, J. Richmond, and D. L. Kaplan, Biomaterials, 24, 401 (2003) DOI ScienceOn
15	J. Moreau, J. S. Chen, D. Kaplan, and G. Altman, Tissue Eng., 12, 2905 (2006) DOI ScienceOn
16	H. B. Fan, H. F. Liu, E. J. W. Wong, S. L. Toh, and J. C. H. Goh, Biomaterials, 29, 3324 (2008) DOI ScienceOn
17	S. W. Ha, H. S. Gracz, A. E. Tonelli, and S. M. Hudson, Biomacromolecules, 6, 2563 (2005) DOI ScienceOn
18	Z. Z. Shao and F. Vollrath, Nature, 418, 741 (2002) DOI PUBMED ScienceOn
19	K. H. Lee, Macromol. Rapid Comm., 25, 1792 (2004) DOI ScienceOn
20	J. Magoshi, Y. Magoshi, M. A. Becker, and S. Nakamura, Abstracts of Papers of the American Chemical Society, 212, 53 (1996)
21	J. Magoshi, Y. Magoshi, T. Tanaka, S. Inoue, M. Kobayashi, Tsuda H, M. A. Becker, H. Zhang, and S. Nakamura, Abstracts of Papers of the American Chemical Society, 221, U575 (2001)
22	M. Rossle, P. Panine, V. S. Urban, and C. Riekel, Biopolymers, 74, 316 (2004) DOI ScienceOn
23	T. Asakura, K. Suita, T. Kameda, S. Afonin, and A. S. Ulrich, Magn. Reson. Chem., 42, 258 (2004) DOI ScienceOn
24	C. S. Ki, I. C. Um, and Y. H. Park, Polymer, 50, 4618 (2009) DOI ScienceOn
25	M. Santin, A. Motta, G. Freddi, and M. Cannas, J. Biomed. Mater. Res., 46, 382 (1999) DOI ScienceOn
26	K. Inouye, M. Kurokawa, S. Nishikawa, and M. Tsukada, J. Biochem. Bioph. Meth., 37, 159 (1998) DOI ScienceOn
27	Y. Wang, H. J. Kim, G. Vunjak-Novakovic, and D. L. Kaplan, Biomaterials, 24, 6064 (2006)
28	L. Meinel, R. Fajardo, S. Hofmann, R. Langer, J. Chen, B. Snyder, G. Vunjak-Novakovic, and D. Kaplan, Bone, 37, 688 (2005) DOI ScienceOn
29	K. Ohgo, F. Bagusat, T. Asakura, and U. Scheler, J. Am. Chem. Soc., 130, 4182 (2008) DOI ScienceOn
30	L. F. Drummy, B. L. Farmer, and R. R. Naik, Soft Matter, 3, 877 (2007) DOI ScienceOn
31	H. Yoshimoto, Y. M. Shin, H. Terai, and J. P. Vacanti, Biomaterials, 24, 2077 (2003) DOI ScienceOn
32	M. Simonet, O. D. Schneider, P. Neuenschwander, and W. J. Stark, Polym. Eng. Sci., 47, 2020 (2007) DOI ScienceOn
33	Y. Takahashi, M. Gehoh, and K. Yuzuriha, Inter. J. Biol. Macromol., 24, 127 (1999) DOI ScienceOn
34	D. H. Roh, S. Y. Kang, J. Y. Kim, Y. B. Kwon, H. Y. Kweon, K. G. Lee, Y. H. Park, R. M. Baek, C. Y. Heo, J. Choe, and J. H. Lee, J. Mater. Sci. Mater. M., 17, 547 (2006) DOI ScienceOn
35	A. Ochi, K. S. Hossain, J. Magoshi, and N. Nemoto, Biomacromolecules, 3, 1187 (2002) DOI ScienceOn
36	S. J. He, R. Valluzzi, and S. P. Gido, Inter. J. Biol. Macromol., 24, 187 (1999) DOI PUBMED ScienceOn
37	J. E. Moreau, J. S. Chen, R. L. Horan, D. L. Kaplan, and G. H. Altman, Tissue Eng., 11, 1887 (2005) DOI ScienceOn
38	Y. Nakazawa and T. Asakura, Macromolecules, 35, 2393 (2002) DOI ScienceOn
39	M. Fini, A. Motta, P. Torricelli, G. Glavaresi, N. N. Aldini, M. Tschon, R. Giardino, and C. Migliaresi, Biomaterials, 26, 3527 (2005) DOI ScienceOn
40	H. Saito, R. Tabeta, T. Asakura, Y. Iwanaga, A. Shoji, T. Ozaki, and I. Ando, Macromolecules, 17, 1405 (1984) DOI
41	C. S. Ki, J. W. Kim, H. J. Oh, K. H. Lee, and Y. H. Park, Inter. J. Biol. Macromol., 41, 346 (2007) DOI ScienceOn
42	T. Asakura, M. Y. Yang, T. Kawase, and Y. Nakazawa, Macromolecules, 38, 3356 (2005) DOI ScienceOn
43	N. Minoura, S. I. Aiba, M. Higuchi, Y. Gotoh, M. Tsukada, and Y. Imai, Biochem. Bioph. Res. Co., 208, 511 (1995) DOI ScienceOn
44	X. Hu, D. Kaplan, and P. Cebe, Macromolecules, 41, 3939 (2008) DOI ScienceOn
45	K. Yamamoto, N. Tomita, Y. Fukuda, S. Suzuki, N. Igarashi, T. Suguro, and Y. Tamada, Biomaterials, 28, 1838 (2007) DOI ScienceOn
46	D. Marolt, A. Augst, L. E. Freed, C. Vepari, R. Fajardo, N. Patel, M. Gray, M. Farley, D. Kaplan, and G. Vunjak-Novakovic, Biomaterials, 27, 6138 (2006) DOI ScienceOn
47	J. R. Mauney, T. Nguyen, K. Gillen, C. Kirker-Head, J. M. Gimble, and D. L. Kaplan, Biomaterials, 28, 5280 (2007) DOI ScienceOn
48	C. S. Ki, J. W. Kim, J. H. Hyun, K. H. Lee, M. Hattori, D. K. Rah, and Y. H. Park, J. Appl. Polym. Sci., 106, 3922 (2007) DOI ScienceOn
49	C. Vepari and D. L. Kaplan, Prog. Polym. Sci., 32, 991 (2007) DOI ScienceOn
50	J. Magoshi, Y. Magoshi, and S. Nakamura, Polym. Comm., 26, 60 (1985)
51	T. Asakura, T. Yamane, Y. Nakazawa, T. Kameda, and K. Ando, Biopolymers, 58, 521 (2001) DOI ScienceOn
52	X. Chen, D. P. Knight, Z. Z. Shao, and F. Vollrath, Polymer, 42, 9969 (2001) DOI ScienceOn
53	H. S. Baek, Y. H. Park, C. S. Ki, J. C. Park, and D. K. Rah, Surf. Coat. Tech., 202, 5794 (2008) DOI ScienceOn
54	C. Z. Zhou, F. Confalonieri, N. Medina, Y. Zivanovic, C. Esnault, T. Yang, M. Jacquet, J. Janin, M. Duguet, R. Perasso, and Z. G. Li, Nucleic Acids Res., 28, 2413 (2000) DOI ScienceOn
55	C. S. Ki, E. H. Gang, I. C. Um, and Y. H. Park, J. Membrane Sci., 302, 20 (2007) DOI ScienceOn
56	J. E. Moreau, D. S. Bramono, R. L. Horan, D. L. Kaplan, and G. H. Altman, Tissue Eng., 14, 1161 (2008) DOI ScienceOn
57	C. Z. Zhou, F. Confalonieri, M. Jacquet, R. Perasso, Z. G. Li, and J. Janin, Proteins, 44, 119 (2001) DOI ScienceOn
58	T. Tanaka, J. Magoshi, Y. Magoshi, S. Inoue, M. Kobayashi, H. Tsuda, and S. Nakamura, Abstracts of Papers of the American Chemical Society, 222, U251 (2001)
59	I. C. Um, H. Y. Kweon, K. G. Lee, and Y. H. Park, Inter. J. Biol. Macromol., 33, 203 (2003) DOI ScienceOn
60	J. S. Chen, G. H. Altman, V. Karageorgiou, R. Horan, A. Collette, V. Volloch, T. Colabro, and D. L. Kaplan, J. Biomed. Mater. Res. A, 67A, 559 (2003) DOI
61	Y. Takasu, H. Yamada, and K. Tsubouchi, Biosci. Biotech. Bioch., 66, 2715 (2002) DOI ScienceOn
62	G. Y. Li, P. Zhou, Z. Z. Shao, X. Xie, X. Chen, H. H. Wang, L. J. Chunyu, and T. Y. Yu, Eur. J. Biochem., 268, 6600 (2001) DOI ScienceOn
63	R. Nazarov, H. J. Jin, and D. L. Kaplan, Biomacromolecules, 5, 718 (2004) DOI ScienceOn
64	P. Zhou, X. Xie, D. P. Knight, X. H. Zong, F. Deng, and W. H. Yao, Biochemistry, 43, 11302 (2004) DOI ScienceOn
65	T. Huang, P. Ren, and B. Huo, J. Appl. Polym. Sci., 106, 4054 (2007) DOI ScienceOn
66	C. Vepari and D. L. Kaplan, Prog. Polym. Sci., 32, 991 (2007) DOI ScienceOn
67	H. J. Jin, J. S. Chen, V. Karageorgiou, G. H. Altman, and D. L. Kaplan, Biomaterials, 25, 1039 (2004) DOI ScienceOn
68	H. J. Kim, U. J. Kim, H. S. Kim, C. Li, M. Wada, G. G. Leisk, and D. L. Kaplan, Bone, 42, 1226 (2008) DOI ScienceOn
69	G. H. Altman, R. L. Horan, H. H. Lu, J. Moreau, I. Martin, J. C. Richmond, and D. L. Kaplan, Biomaterials, 23, 4131 (2002) DOI ScienceOn
70	Y. H. Yang, Z. Z. Shao, X. Chen, and P. Zhou, Biomacromolecules, 5, 773 (2004) DOI ScienceOn
71	C. S. Ki, S. Y. Park, H. J. Kim, H. M. Jung, K. M. Woo, J. W. Lee, and Y. H. Park, Biotechnol. Lett., 30, 405 (2008) DOI ScienceOn
72	M. Tsukada and K. Hirabayashi, Sen-i Gakkaishi, 39, 265 (1983) DOI
73	C. M. Li, H. J. Jin, G. D. Botsaris, and D. L. Kaplan, Abstracts of Papers of the American Chemical Society, 226, U498 (2003)
74	J. Magoshi, Y. Magoshi, M. Kato, M. A. Becker, H. Zhang, and S. Nakamura, Abstracts of Papers of the American Chemical Society, 217, U469 (1999)
75	M. Tsukada, Y. Gotoh, and N. Minoura, J. Sericulture Sci. Jpn., 59, 325 (1990)
76	A. Raghu, R. Somashekar, and S. Ananthamurthy, J. Polym. Sci. Polym. Phys., 45, 2555 (2007) DOI ScienceOn
77	M. Lovett, C. Cannizzaro, L. Daheron, B. Messmer, G. Vunjak-Novakovic, and D. L. Kaplan, Biomaterials, 28, 5271 (2007) DOI ScienceOn
78	S. Min, T. Nakamura, A. Teramoto, and K. Abe, Sen-i Gakkaishi, 54, 270 (1998) DOI
79	Y. Yang, F. Ding, H. Wu, W. Hu, W. Liu, H. Liu, and X. Gu, Biomaterials, 28, 5526 (2007) DOI ScienceOn
80	G. D. Kang, K. H. Lee, C. S. Ki, J. H. Nahm, and Y. H. Park, Macromol. Res., 12, 534 (2004) DOI
81	T. Asakura, M. Hamada, Y. Nakazawa, S. W. Ha, and D. P. Knight, Biomacromolecules, 7, 627 (2006) DOI ScienceOn
82	A. J. Meinel, K. E. Kubow, E. Klotzsch, M. Garcia-Fuentes, M. L. Smith, V. Vogel, H. P. Merkle, and L. Meinel, Biomaterials, 30, 3058 (2009) DOI ScienceOn
83	B. M. Min, L. Jeong, K. Y. Lee, and W. H. Park, Macromol. Biosci., 6, 285 (2006) DOI ScienceOn
84	K. E. Park, S. Y. Jung, S. J. Lee, B. M. Min, and W. H. Park, Inter. J. Biol. Macromol., 38, 165 (2006) DOI PUBMED ScienceOn
85	J. Magoshi, Y. Magoshi, and S. Nakamura, Appl. Polym. Symp., 41, 187 (1985)
86	A. Matsumoto, J. Chen, A. L. Collette, U. J. Kim, G. H. Altman, P. Cebe, and D. L. Kaplan, J. Phys. Chem. B, 110, 21630 (2006) DOI ScienceOn