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Synthesis and Characterization of MPEG-b-PDPA Amphiphilic Block Copolymer via Atom Transfer Radical Polymerization and Its pH-Dependent Micellar Behavior  

Dayananda, Kasala (Polymer Technology Institute)
Kim, Min-Sang (Department of Polymer Science and Engineering, SungKyunKwan University)
Kim, Bong-Sup (Polymer Technology Institute)
Lee, Doo-Sung (Polymer Technology Institute)
Publication Information
Macromolecular Research / v.15, no.4, 2007 , pp. 385-391 More about this Journal
Abstract
Block copolymer micelles are generally formed via the self-assembly of amphiphilic block copolymers in an aqueous medium. The hydrophilic and hydrophobic blocks form shell and core micelles, respectively. The block copolymers of methoxy poly(ethylene glycol) (MPEG)-b-poly(2-diisopropylamino)ethyl methacrylate (PDPA) were synthesized via atom transfer radical polymerization, with the macro initiator synthesized by the coupling of 2-bromoisobutyryl bromide with MPEG in the presence of a triethyl amine base catalyst. The atom transfer radical polymerization of 2-diisopropylamino)ethyl methacrylate was performed in conjunction with an N,N,N',N",N"-pentamethyl-diethylenetriamine/copper bromide catalyst system, in DMF, at $70^{\circ}C$. The pH induced micellization/demicellization was studied using fluorescence, with a pyrene probe. Furthermore, the pH dependent micellization was confirmed using the microviscosity method, with a dipyme fluorescence probe. The pH dependant micelle size distribution was studied using dynamic light scattering. The characterization of the synthesized polymers was established using gel permeation chromatography and from the $^1H-nuclear$ magnetic resonance spectroscopy.
Keywords
atom transfer radical polymerization; block copolymers; micelles; macroinitiator; poly(2-(diisopropylamino)ethyl methacrylate (PDPA);
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1 M. Wilhelm, C. Zhao, Y. Wang, R. Xu, M. A. Winnik, J. Mura, G. Reiss, and M. D. Croucher, Macromolecules, 24, 1033 (1991)
2 I. F. Tannock and D. Rotin, Cancer Res., 49, 4373 (1989)
3 K. Matyjaszewski and J. Xia, Chem. Rev., 101, 2921 (2001)   DOI   ScienceOn
4 K. Jankova, X. Chen, J. Kops, and W. Batsberg, Macromolecules, 31, 538 (1998)
5 M. D. Determan, J. P. Cox, S. Seifert, P. Thiyagarajan, and S. K. Mallapragada, Polymer, 46, 6933 (2005)   DOI   ScienceOn
6 K. Kalyanasundaram and J. K. Thomas, J. Am. Chem. Soc., 99, 2039 (1977)
7 A. Yekta, X. Bai, J. Duhamel, H. Adiwidjaja, and M. A. Winnik, Macromolecules, 28, 956 (1995)
8 X. S. Wang, S. F. Lascelle, R. A. Jackson, and S. P. Armes, Chem. Commun., 1817 (1999)
9 X. S. Wang and S. P. Armes, Macromolecules, 33, 6640 (2000)
10 E. J. Ashford, V. Naldi, R. O'Dell, N. C. Billinggham, and S. P. Armes, Chem. Commun., 1285 (1999)
11 Y. Tang, S. Y. Liu, S. P. Armes, and N. C. Billingham, Biomacromolecules, 4, 1636 (2003)
12 W. S. Shim, J. S. Lee, and D. S. Lee, Macromol. Res., 13, 344 (2005)
13 T. Nivaggioli, B. Tsao, P. Alexandridis, and T. A. Hatton, Langmuir, 11, 119 (1995)
14 E. S. Gil and S. M. Hudson, Prog. Polym. Sci., 29, 1173 (2004)   DOI   ScienceOn
15 M. Kamigaito, T. Ando, and M. Sawamoto, Chem. Rev., 101, 3689 (2001)   DOI   ScienceOn
16 R. Roesler, G. W. M. Vandermeulen, and H. A. Klok, Adv. Drug Delivery Rev., 53, 95 (2001)   DOI   ScienceOn
17 J. L. S. Au, S. H. Jang, J. Zheng, C. T. Chen, S. Song, L. Hu, and M. G. Weintjes, J. Control. Release, 74, 31 (2001)   DOI
18 S. R. Tonge and B. J. Tighe, Adv. Drug Deliv. Rev., 53, 109 (2001)   DOI   ScienceOn
19 Y. Ma, Y. Tang, N. C. Billingham, S. P. Armes, A. L. Lewis, A. W. Lloyd, and J. P. Salvage, Macromolecules, 36, 3475 (2003)
20 A. S. Hoffman, Environmentally Sensitive Polymers and Hydrogels, MRS Bull., September, 1991, pp. 42-46
21 B. Reining, H. Keul, and H. Hocker, Polymer, 43, 3139 (2002)
22 N. Murthy, J. R. Robichaud, D. A. Tirrell, P. S. Stayton, and A. S. Hoffman, J. Control. Release, 61, 137 (1999)
23 N. V. Tsarevsky, T. Sarbu, B. Gobelt, and K. Matyjaszewski, Macromolecules, 35, 6142 (2002)   DOI   ScienceOn
24 R. K. Jain, J. Control. Release, 53, 49 (1998)
25 M. Vamvakaki, N. C. Billingam, and S. P. Armes, Macromolecules, 32, 2088 (1999)
26 A. S. Lee, V. Butun, M. Vamvakaki, S. P. Armes, J. A. Pople, and A. P. Gast, Macromolecules, 35, 8540 (2002)   DOI   ScienceOn
27 Y. Ma, Y. Tang, N. C. Billingham, S. P. Armes, and A. L. Lewis, Biomacromolecules, 4, 864 (2003)
28 S. I. Kang and Y. H. Bae, J. Control. Release, 80, 145 (2002)
29 P. Alexandriedis, J. F. Holzworth, and T. A. Hatton, Macromolecules, 27, 2414 (1994)
30 G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka, Langumir, 9, 945 (1993)   DOI   ScienceOn