Browse > Article

Polymers for Microfluidic Chips  

Song Simon (Department of Mechanical Engineering, Hanyang University)
Lee Kuen-Yong (Department of Bioengineering, Hanyang University)
Publication Information
Macromolecular Research / v.14, no.2, 2006 , pp. 121-128 More about this Journal
Abstract
Microfluidic systems have attracted much research attention recently in the areas of genomics, proteomics, pharmaceutics, clinical diagnostics, and analytical biochemistry, as they provide miniaturized platforms for conventional analysis techniques. The microfluidic systems allow faster and cheaper analysis using much smaller amounts of sample and reagent than conventional methods. Polymers have recently found useful applications in microfluidic systems due to the wide range of available polymeric materials and the relative ease of chemical modification. This paper discusses the fundamentals of microfluidic systems and the roles, essential properties and various forms of polymers used as solid supports in microfluidic systems, based on the recent advances in the use of polymers for microfluidic chips.
Keywords
microfluidic chip; polymer; solid support; gel; photopolymerization;
Citations & Related Records

Times Cited By Web Of Science : 9  (Related Records In Web of Science)
Times Cited By SCOPUS : 10
연도 인용수 순위
1 D. Kuckling, M. E. Harmon, and C. W. Frank, Macromolecules, 35, 6377 (2002)   DOI   ScienceOn
2 M. E. Harmon, M. Tang, and C. W. Frank, Polymer, 44, 4547 (2003)   DOI   ScienceOn
3 M. Lämmerhofer and W. Linder, in Monolithic Materials, F. Svec, T. B. Tennikova, and Z. Deyl, Eds., Elsevier, Amsterdam, 2003, pp 489-559
4 A. R. Ivanov, L. Zang, and B. L. Karger, Anal. Chem., 75, 5306 (2003)   DOI   ScienceOn
5 D. R. Reyes, D. Isossifidis, P.-A. Auroux, and A. Manz, Anal. Chem., 74, 2623 (2002)   DOI   ScienceOn
6 P.-A. Auroux, D. Isossifidis, D. R. Reyes, and A. Manz, Anal. Chem., 74, 2637 (2002)   DOI   ScienceOn
7 T. Vilkner, D. Janasek, and A. Manz, Anal. Chem., 76, 3373 (2004)   DOI   ScienceOn
8 S. Song, A. K. Singh, T. J. Shepodd, and B. J. Kirby, Anal. Chem., 76, 2367 (2004)   DOI   ScienceOn
9 N. Lion, T. C. Rohner, L. Dayon, I. L. Arnaud, E. Damoc, N. Youhnovski, Z.-Y. Wu, C. Roussel, J. Josserand, H. Jensen, J. S. Rossier, M. Przybylski, and H. H. Gilault, Electrophoresis, 24, 3533 (2003)   DOI   ScienceOn
10 Y. Jiang, P. C. Wang, L. E. Locascio, and C. S. Lee, Anal. Chem., 73, 2048 (2001)   DOI   ScienceOn
11 G. T. A. Kovacs, K. Petersen, and M. Albin, Anal. Chem., 68, A407 (1996)   DOI
12 J. Rossier, F. Reymond, and P. E. Michel, Electrophoresis, 23, 858 (2002)   DOI   ScienceOn
13 M. A. Roberts, J. S. Rossier, P. Bercier, and H. Girault, Anal. Chem., 69, 2035 (1997)   DOI   ScienceOn
14 S. L. R. Barker, D. Ross, M. J. Tarlov, M. Gaitan, and L. E. Locascio, Anal. Chem., 72, 5925 (2000)   DOI   ScienceOn
15 A. C. Henry, T. J. Tutt, M. Galloway, Y. Y. Davidson, C. S. Mcwhorter, S. A. Soper, and R. L. Mccarley, Anal. Chem., 72, 5331 (2000)   DOI   ScienceOn
16 H. Andersson, W. van der Wijngaart, P. Enoksson, and G. Stemme, Sensor Actuat. B-Chem., 67, 203 (2000)   DOI
17 K. Sato, M. Yamanaka, H. Takahashi, M. Tokeshi, H. Kimura, and T. Kitamori, Electrophoresis, 23, 734 (2002)   DOI   ScienceOn
18 N. Lion, J. O. Gellon, H. Jensen, and H. H. Girault, J. Chromatogr. A, 1003, 11 (2003)   DOI
19 K. Morishima, B. D. Bennett, M. T. Dulay, J. P. Quirino, and R. N. Zare, J. Sep. Sci., 25, 1226 (2002)   DOI   ScienceOn
20 K. A. Wolfe, M. C. Breadmore, J. P. Ferrance, M. E. Power, J. F. Conroy, P. M. Norris, and J. P. Landers, Electrophoresis, 23, 727 (2002)   DOI   ScienceOn
21 D. T. Eddington and D. J. Beebe, Adv. Drug Deliv. Rev., 56, 199 (2004)
22 D. J. Beebe, J. S. Moore, J. M. Bauer, Q. Yu, R. H. Liu, C. Devadoss, and B. H. Jo, Nature, 404, 588 (2000)   DOI   ScienceOn
23 S. Song and A. K. Singh, Anal. Bioanal. Chem., 384, 41 (2006)   DOI   ScienceOn
24 D. S. Peterson, Lab Chip, 5, 132 (2005)   DOI   ScienceOn
25 Q. Yu, J. M. Bauer, J. S. Moore, and D. J. Beebe, Appl. Phys. Lett., 78, 2589 (2001)   DOI   ScienceOn
26 S. Y. Chou, P. R. Krauss, and P. J. Renstrom, Science, 272, 85 (1996)   DOI   ScienceOn
27 S. C. Jakeway, A. J. de Mello, and E. L. Russell, Fresenius J. Anal. Chem., 366, 525 (2000)   DOI
28 T. T. Huang, T. Geng, D. Akin, W. J. Chang, J. Sturgis, R. Bashir, A. K. Bhunia, J. P. Robinson, and M. R. Ladisch, Biotechnol. Bioeng., 83, 416 (2003)   DOI   ScienceOn
29 H. Becker and L. E. Locascio, Talanta, 56, 267 (2002)   DOI   ScienceOn
30 E. Verpoorte, Lab Chip, 3, 60N (2003)   DOI
31 D. C. Duffy, J. C. Mcdonald, O. J. A. Schueller, and G. M. Whitesides, Anal. Chem., 70, 4974 (1998)   DOI   ScienceOn
32 N. Xu, Y. Lin, S. A. Hofstadler, D. Matson, C. J. Call, and R. D. Smith, Anal. Chem., 70, 3553 (1998)   DOI   ScienceOn
33 S. Song, A. K. Singh, and B. J. Kirby, Anal. Chem., 76, 4589, (2004)   DOI   ScienceOn
34 W. Jeong, J. Kim, S. Kim, S. Lee, G. Mensing, and D. J. Beebe, Lab Chip, 4, 576 (2004)   DOI   ScienceOn
35 M.-S. Chun, M. S. Shim, and N. W. Choi, Lab Chip, 6, 302 (2006)   DOI   ScienceOn
36 J. S. Rossier, P. Bercier, A. Schwarz, S. Loridant, and H. H. Girault, Langmuir, 15, 5173 (1999)   DOI   ScienceOn
37 K. Sato, M. Tokeshi, T. Odake, H. Kimura, T. Ooi, M. Nakao, and T. Kitamori, Anal. Chem., 72, 1144 (2000)   DOI   ScienceOn
38 S. S. Park, S. I. Cho, M. S. Kim, Y. K. Kim, and B. G. Kim, Electrophoresis, 24, 200 (2003)   DOI   ScienceOn
39 P. C. Wang, D. L. Devoe, and C. S. Lee, Electrophoresis, 22, 3857 (2001)   DOI   ScienceOn
40 J. H. Dai, T. Ito, L. Sun, and R. M. Crooks, J. Am. Chem. Soc., 125, 13026 (2003)   DOI   ScienceOn
41 W. Zhan, G. H. Seong, and R. M. Crooks, Anal. Chem., 74, 4647 (2002)   DOI   ScienceOn
42 T. Rohr, D. F. Ogletree, F. Svec, and J. M. J. Fréchet, Adv. Func. Mater., 13, 264 (2003)   DOI   ScienceOn
43 C. B. Park and D. S. Clark, Biotechnol. Bioeng., 78, 229 (2002)   DOI   ScienceOn
44 W. J. Jeong, J. Y. Kim, J. Choo, E. K. Lee, C. S. Han, D. J. Beebe, G. H. Seong, and S. H. Lee, Langmuir, 21, 3738 (2005)   DOI   ScienceOn
45 J. Gao, J. D. Xu, L. E. Locascio, and C. S. Lee, Anal. Chem., 73, 2648 (2001)   DOI   ScienceOn
46 D. S. Peterson, T. Rohr, F. Svec, and J. M. J. Fréchet, Anal. Chem., 75, 5328 (2003)   DOI   ScienceOn
47 T. Rohr, E. F. Hilder, J. J. Donovan, F. Svec, and J. M. J. Fréchet, Macromolecules, 36, 1677 (2003)   DOI   ScienceOn
48 M. L. Branham, W. Maccrehan, and L. E. Locascio, J. Capillary Electophoresis, 6, 43 (1999)
49 K. M. Kurian, C. J. Watson, and A. H. Wyllie, J. Pathol., 187, 267 (1999)   DOI   ScienceOn
50 H. Andersson, C. Jonsson, C. Moberg, and G. Stemme, Electrophoresis, 22, 3876 (2001)   DOI   ScienceOn
51 A. Malik, Electrophoresis, 23, 3973 (2002)   DOI   ScienceOn
52 P. D. Dalton, L. Flynn, and M. S. Shoichet, Biomaterials, 23, 3843 (2002)   DOI   ScienceOn
53 H. Hisamoto, Y. Shimizu, K. Uchiyama, M. Tokeshi, Y. Kikutani, A. Hibara, and T. Kitamori, Anal. Chem., 75, 350 (2003)   DOI   ScienceOn
54 H. Mcnally, M. Pingle, S. W. Lee, D. Guo, D. E. Bergstrom, and R. Bashir, Appl. Surf. Sci., 214, 109 (2003)   DOI   ScienceOn
55 C. Wang, R. Oleschuk, F. Ouchen, J. J. Li, P. Thibault, and D. J. Harrison, Rapid Commun. Mass Spec., 14, 1377 (2000)   DOI   ScienceOn
56 L. E. Locascio, C. E. Perso, and C. S. Lee, J. Chromatogr. A, 857, 275 (1999)   DOI
57 A. Russom, A. Ahmadian, H. Andersson, P. Nilsson, and G. Stemme, Electrophoresis, 24, 158 (2003)   DOI   ScienceOn
58 M. J. Heller, Annu. Rev. Biomed. Eng., 4, 129 (2002)   DOI   ScienceOn
59 J. Brandrup, E. H. Immergut, and E. A. Grulke, Eds., Polymer Handbook, 4th Ed., John Wiley & Sons, New York, 1999
60 C. A. Harper, Modern Plastics Handbook, McGraw-Hill, New York, 2000
61 C. Yu, S. Mutlu, P. Selvaganapathy, C. H. Mastrangelo, F. Svec, and J. M. J. Fréchet, Anal. Chem., 75, 1958 (2003)   DOI   ScienceOn
62 T. Rohr, C. Yu, M. H. Davey, F. Svec, and J. M. J. Fréchet, Electrophoresis, 22, 3959 (2001)   DOI   ScienceOn
63 D. Erickson and D. Li, Anal. Chem. Acta, 507, 11 (2004)   DOI   ScienceOn
64 K. W. Ro, W.-J. Chang, H. Kim, Y.-M. Koo, and J. H. Hahn, Electrophoresis, 24, 3253 (2003)   DOI   ScienceOn
65 W. P. Hoffman, H. T. Phan, and P. G. Wapner, Mater. Res. Innov., 2, 87 (1998)   DOI   ScienceOn
66 R. F. Ismagilov, J. M. K. Ng, P. J. A. Kenis, and G. M. Whitesides, Anal. Chem., 73, 5207 (2001)   DOI   ScienceOn
67 J. S. Rossier, G. Gokulrangan, H. H. Girault, S. Svojanovsky, and G. S. Wilson, Langmuir, 16, 8489 (2000)   DOI   ScienceOn
68 N. Malmstadt, P. Yager, A. S. Hoffman, and P. S. Stayton, Anal. Chem., 75, 2943, (2003)   DOI   ScienceOn
69 P. C. Wang, J. Gao, and C. S. Lee, J. Chromatogr. A, 942, 115 (2002)   DOI
70 P. Arenkov, A. Kukhtin, A. Gemmell, S. Voloshchuk, V. Chupeeva, and A. Mirzabekov, Anal. Biochem., 278, 123 (2000)   DOI   ScienceOn