Browse > Article

Phase Behaviors of Binary Protein Systems: Consideration of Structural Effects  

Kim, Sang-Gon (Division of Chemical Engineering, Hanyang University)
Kong, Sung-Ho (Division of Chemical Engineering, Hanyang University)
Bae, Young-Chan (Division of Chemical Engineering, Hanyang University)
Kim, Sun-Joon (Department of Environmental Geosystem Engineering, Hanyang University)
Publication Information
Macromolecular Research / v.11, no.4, 2003 , pp. 241-249 More about this Journal
Abstract
A molecular-thermodynamic model to describe the salt-induced protein precipitation is developed based on the perturbation theory. We employed the modified perturbed hard-sphere-chain (PHSC) equation of state for copolymer mixtures to take into account the pre-aggregation effect among protein particles. Hypothetical pressure-composition diagrams are computed with various size differences and salt concentrations. The precipitation behaviors are also studied for various types of pre-aggregation effect for the given systems.
Keywords
pre-aggregation; binary protein system; interaction potentials; phase equilibria;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
연도 인용수 순위
1 M. Q. Niederauer and C. E. Glatz, Adv. Biochem. Eng. TechnoI., 47, 159 (1992)   DOI
2 C. J. Coen, H. W. Blanch, and J. M. Prausnitz, AlChE J., 41, 1(1995)
3 E. Verwey and J. Overbeek, Theory of Stability of Lyophobic Colloids, Elsevier, Amsterdam, 1948
4 A. Vrij, Pure Appl. Chem., 48, 471 (1976)
5 H. De Hek and A. Vrij, J. Colloid Interf. Sci., 41, 996 (1995)
6 Y. Song, S. M. Lambert. and J. M. Prausnitz, Macromolecules, 27, 441 (1994)
7 Y. Song, S. M. Lambert, and J. M. Prausnitz, Ind. Eng. Chem. Res., 33 1047(1994)
8 R. A. Curtis, C. Steinbrecher, M. Heinemann, H. W. Blanch, and J. M. Prausnitz. Biophys. Chem., 98, 249 (2002)
9 J. Wu and J. M. Prausnitz, Fluid Phase Equilibria, 155, 139 (1999)
10 P. A. Belter, E. L. Cussler, and W. S. Hu, Bioseparations. Downstream Processing Operations, Wiley, New York, 1998
11 S. G. Kim and Y. C. Bae, Korean J. Chem. Eng., 17. 638 (2000)
12 R. N. Haire, W. A. Tisel, J. C. White, and A. Rosenberg, Biopolymers, 23, 2761 (1984)
13 P. A. Albertsson, Partition of Cell Particles and Macromolecules. Wiley, New York, 1986
14 S. Askura and F. Oosawa, J. Polym. Sci., 33, 183 (1958)
15 H. C. Hamaker, Physica IV, 10, 1058 (1937)
16 S. G. Kim and Y. C. Bae, Macromol. Res., 11, 53 (2003)
17 A. P. Gast, C. K. Hall, and W. G. Russel, J. Farad. Discuss. Chem. Soc., 76, 189 (1983b)
18 Y. Song, S. M. Lambert, and J. M. Prausnitz, Chem. Eng. Sci., 49, 2765 (1994)
19 D. A. Young, J. Chem. Phys., 98, 9819 (1993)
20 P. R. Foster, P. Dunhill, and M. D. Lilly, Biochem. Biophys. Acta, 317, 505 (1975)
21 T. Hino, Y. Song, and J. M. Prausnitz, J. Polym. Sci., 34, 1977 (1996)
22 J. F. Joanny, L. Leibler, and P. G. de Gennes, J. Polym. Sci., Polym. Phys., 17, 1073 (1979)
23 H. Mahadevan and C. K. Hall, AIChE J., 36, 1517 (1990)
24 Y. C. Chiew, Molec. Phys., 70, 129 (1990)
25 M. J. Grimson. J. Chem. Soc. Farad. Trans., 79, 817 (1983)
26 D. Kuehner. H. W. Blanch, and J. M. Prausnitz, Fluid Phase Equilibria, 116. 140(1996)
27 H. Mahadevan and C. K. Hall, AlChE J., 38, 573 (1992)
28 F. Rothstein, Protein Precipitation Process Engineering, R. G. Harrion, Ed., Dekker, New York, 1994
29 D. Kuehner, C. Heyer, C. Ramsch, U. M. Fornefeld, H. W. Blanch, and J. M. Prausnitz, Biophys. J., 73, 3211 (1997)
30 N. F. Carnahan and K. E. Starling, J. Chem. Phys., 51, 635 (1969)
31 V. Vlachy and J. M. Prausnitz, J. Phys. Chem., 96, 6465 (1992)
32 Y. C. Shih, H. W. Blanch, and J. M. Prausnitz, Biotech Bioeng., 40, 1155 (1992)
33 J. M. Victor and J. P. Hansen, J. Phys. Lett., 45, L-307 (1984)
34 T. Hino, Y. Song, and J. M. Prausnitz, J. Polym. Sci., 34, 1977 (1996)
35 F. Rothstein, Protein Purification Process Engineering, R. G. Harvision, Ed., Macel Dekker, New York, 1994
36 V. Vlachy, H. W. Blanch, and J. M. Prausnitz, AIChE J., 39, 215 (1993)