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http://dx.doi.org/10.5478/MSL.2021.12.1.11

Determination of Nitarsone in Pork, Egg, Milk, Halibut, Shrimp, and Eel Using QuEChERS and LC-MRM  

Kim, Jin Hee (College of Pharmacy, Dankook University)
Jang, Yong Jin (College of Pharmacy, Dankook University)
Kim, Dong Yoon (College of Pharmacy, Dankook University)
Lee, Hyo Chun (College of Pharmacy, Dankook University)
Choi, Yong Seok (College of Pharmacy, Dankook University)
Publication Information
Mass Spectrometry Letters / v.12, no.1, 2021 , pp. 11-15 More about this Journal
Abstract
Nitarsone is an organoarsenic antiprotozoal drug widely used to treat blackhead disease in turkeys and chickens. However, since its biological conversion into inorganic arsenic, a carcinogen was known, its residue in foods should be regulated. Thus, here, a novel method to determine residual nitarsone in various food commodities (pork, milk, egg, halibut, eel, and shrimp) using QuEChERS and LC-MRM was developed. The developed method was successfully validated through specificity, linearity (coefficient of determination, at least 0.991), recovery (R, 63.6 - 85.6%), precision (the relative standard deviation of R, 0.5 - 10.6%), and sensitivity (the lower limit of quantitation, 5 ppb) by following the Ministry of food and drug safety (MFDS) guidelines. The present method is the first mean to quantitate nitarsone using LC-MRM, and it was designed to be conveniently merged into a new method to quantitate multiple veterinary drugs for the positive list system (PLS). Therefore, the present method could contribute to fortify the food safety system in South Korea.
Keywords
nitarsone; food; QuEChERS; MRM; PLS;
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1 Cui, J; Xiao, Y; Dai, L; Zhao, X; Wang, Y. Food Anal. Methods 2013, 6, 370, DOI: 10.1007/s12161-012-9533-0.   DOI
2 Eom, H. Y.; Yang, D. H.; Suh, J. H.; Kim, U. Y.; Kim, J. H.; Cho, H. D.; Han, S. B. J. Chromatogr. B 2015, 1006, 151, DOI: http://dx.doi.org/10.1016/j.jchromb.2015.10.034.   DOI
3 Nachman, K. E.; Love, D. E.; Baron, P. A.; Nigra, A. E.; Murko, M.; Raber, G.; Francesconi, K. A.; Bavas-acien, A. Environ. Health Perspect. 2017, 125, 363, DOI: 10.1289/EHP225.   DOI
4 Liu, D. F.; Huang, X. N.; Cheng, R. F.; Min, D.; Cheng, L.; Zhao, F.; Chen, J. J. ACS EST Water, accepted, DOI: https://doi.org/10.1021/acsestwater.0c00124.   DOI
5 Liu, L.; He, B.; Yun, Z.; Sun, J.; Jiang, G. J. Chromatogr. A 2013, 1304, 227, DOI: 10.1016/j.chroma.2013.07.034.   DOI
6 Reid, M. S.; Hoy K. S.; Schofield, J. R. M.; Uppal, J. S.; Lin, Y.; Lu, X.; Peng, H.; Chris Le, X. Trends Anal. Chem. 2020, 123, 115770, DOI: https://doi.org/10.1016/j.trac.2019.115770.   DOI
7 Sanchez-Rodas, D.; Gomez-Ariza, J. L.; Oliveira, V. Anal. Bioanal. Chem. 2006, 385, 1172, DOI: 10.1007/s00216-006-0379-4.   DOI
8 Czaplickaa, M.; Jaworekb, K.; Klytaa, J. Desalin. Water Treat. 2019, 172, 386, DOI: 10.5004/dwt.2019.24610.   DOI
9 Chen, D.; Zhang, H.; Tao, Y.; Wang, Y.; Huang, L.; Liu, Z.; Pan, Y.; Peng, D.; Wang, X.; Dai, M.; Yuan, Z. J. Chromatogr. B 2011, 879, 716, DOI: 10.1016/j.jchromb.2011.02.013.   DOI
10 Wilschefski, S. C.; Baxter, M. R. Clin. Biochem. Rev. 2019, 40, 115, DOI: 10.33176/AACB-19-00024.   DOI
11 Telgmann, L.; Lindner, U.; Lingott, J.; Jakubowski, N. Phys. Sci. Rev. 2016, 1, 20160064, DOI: https://doi.org/10.1515/psr-2016-0058.   DOI
12 Ministry of food and drug safety, South Korea, Guidelines for analytical method validation.; See https://www.mfds.go.kr/brd/m_210/view.do?seq=12920&srchFr=&srchTo=&srchWord=%ED%99%94%EC%9E%A5%ED%92%88&srchTp=0&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&page=2.
13 Ministry of food and drug safety, South Korea. Food and nutrient data system.; See https://www.foodsafetykorea.go.kr/portal/healthyfoodlife/foodnutrient/simpleSearch.do?menu_grp=MENU_NEW03&menu_no=2805.
14 Cho, H. R.; Park, J. S.; Kim, J. H.; Han, S. B.; Choi, Y. S. Anal. Bioanal. Chem. 2015, 407, 9043, DOI: 10.1007/s00216-015-9071-x.   DOI
15 Cho, H. R.; Kim, D. Y.; Lee, H. C.; Han, S. B.; Shin, H. C.; Choi, Y. S. Mass Spectrom. Lett. 2018, 4, 100, DOI: 10.5478/MSL.2018.9.4.100.   DOI
16 Ministry of food and drug safety, South Korea. PLS on veterinary drugs.; See https://mfds.go.kr/brd/m_209/view.do?seq=43393.