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http://dx.doi.org/10.5478/MSL.2016.7.2.45

UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa  

Kang, Kyo Bin (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
Jang, Dae Sik (Department of Life and Nanopharmaceutical Sciences and College of Pharmacy, Kyung Hee University)
Kim, Jinwoong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
Sung, Sang Hyun (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
Publication Information
Mass Spectrometry Letters / v.7, no.2, 2016 , pp. 45-49 More about this Journal
Abstract
An UHPLC-ESI-qTOF-MS analytical method was developed for cyclopeptide alkaloids in the seeds of Ziziphus jujuba var. spinosa (Semen Ziziphi Spinosae), which is a commonly used herb in Chinese and Korean traditional medicines. Considering the basicity of cyclopeptide alkaloids, a specific separation method was developed for an UHPLC system. The compounds were detected by DAD and ESI-qTOF-MS, and their fragmentation patterns were also acquired by MSE technologies. Peak-picking of major compounds was performed with nine previously isolated compounds and two reference standard compounds. Tandem MS fragmentation behaviors of type-Ia and -Ib cyclopeptide alkaloids were investigated with the acquired data to develop a strategy for dereplication of other cyclopeptide alkaloid compounds in Z. jujuba var. spinosa. Two more cyclopeptide alkaloids were tentatively identified with UHPLC-ESI-qTOF-MS using this method.
Keywords
Cyclopeptide alkaloids; UHPLC-ESI-qTOF-MS; Ziziphus jujuba var. spinosa;
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