Browse > Article
http://dx.doi.org/10.5478/MSL.2015.6.2.48

Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes  

Rehman, Shaheed Ur (Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
Kim, n Sook (Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
Choi, Min Sun (Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
Luo, Zengwei (School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology)
Yao, Guangming (School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology)
Xue, Yongbo (School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology)
Zhang, Yonghui (School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology)
Yoo, Hye Hyun (Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
Publication Information
Mass Spectrometry Letters / v.6, no.2, 2015 , pp. 48-51 More about this Journal
Abstract
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
Keywords
kinsenoside; stability; liver microsomes;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Masimirembwa, C. M.; Thompson, R.; Andersson, T. B. Comb. Chem. High Throughput Screen 2001, 4, 245.   DOI
2 Du, X. M.; Irino, N.; Furusho, N.; Hayashi, J.; Shoyama, Y. J. Nat. Med. 2008, 62, 132.   DOI
3 Du, X.; Sun, N.; Tamura, T.; Mohri, A.; Sugiura, M.; Yoshizawa, T.; Irino, N.; Hayashi, J.; Shoyama, Y. Biol. Pharm. Bull. 2001, 24, 65.   DOI
4 Zhang, Y.; Cai, J.; Ruan, H.; Pi, H.; Wu, J. J. Ethnopharmacol. 2007, 114, 141.   DOI
5 Hsiao, H. B.; Wu, J. B.; Lin, H.; Lin, W. C. Shock 2011, 35, 184.   DOI
6 Shih, C. C.; Wu, Y. W.; Lin, W. C. Clin. Exp. Pharmacol. Physiol. 2002, 29: 684.   DOI
7 Wu, J. B.; Lin, W. L.; Hsieh, C. C.; Ho, H. Y.; Tsay, H. S.; Lin, W. C. Res. 2007, 21, 58.
8 Hsiao, H. B.; Lin, H.; Wu, J. B.; Lin, W. C. Osteoporis. Int. 2013, 24, 1663.   DOI
9 Liu, Z. L.; Liu, Q.; Xiao, B.; Zhou, J.; Zhang, J. G.; Li, Y. Fitoterapia 2013, 86, 163.   DOI