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http://dx.doi.org/10.5478/MSL.2015.6.2.27

Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry  

Kim, Jeongkwon (Department of Chemistry, Chungnam National University)
Publication Information
Mass Spectrometry Letters / v.6, no.2, 2015 , pp. 27-30 More about this Journal
Abstract
This article reviews the fundamentals of sample preparation used in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). MALDI is a soft ionization method used to generate analyte ions in their intact forms, which are then detected in MS analysis. MALDI-MS boasts fast analysis times and easy-to-use operation. The disadvantages of MALDI-MS include the occurrence of matrix-associated peaks and inhomogeneous distribution of analyte within the matrix. To overcome the disadvantages of MALDI-MS, various efforts have been directed such as using different matrices, novel matrix systems, various additives, and different sample preparation methods. These various efforts will be discussed in detail. This article will benefit those who would like to obtain basic knowledge of MALDI sample preparation and those who would like to use MALDI-MS in their chemical analyses.
Keywords
MALDI-MS; 2,5-dihydrobenzoic acid; α-cyano-4-hydroxycinnamic acid; sinapic acid; additives;
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