[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5478/MSL.2013.4.4.91

Simulation Study to Improve Ion Transmission Efficiency in Mass Spectrometry with a Dual Ion Funnel Ion Source

Baek, Sun Jong (Division of Mass Spectrometry Research, Korea Basic Science Institute)
Kim, Seung Yong (Division of Mass Spectrometry Research, Korea Basic Science Institute)
Kim, Taeman (MS Development Group, Genomic System Research Center, Bioneer Corporation)
Kim, Hyun Sik (Division of Mass Spectrometry Research, Korea Basic Science Institute)

Publication Information

Mass Spectrometry Letters / v.4, no.4, 2013 , pp. 91-94 More about this Journal

Abstract

We performed computer simulations to improve transmission efficiencies of a dual ion funnel system implemented on an FT-ICR MS. We found that the low m/z range from 50 to 150 could be significantly improved by operating the two ion funnels at different RF amplitudes. These new operational conditions could be applied to analyze metabolome samples, which require high sensitivity in the m/z range from 50 to 1,000.

Keywords

FT-ICR; ion funnel; trajectory calculation; simulations; SIMION;

Citations & Related Records

Reference

1	Shaffer, S. A.; Tang, K.; Anderson, G. A.; Prior, D. C.; Udseth, H. R.; Smith, R. D. Rapid Communications in Mass Spectrometry 1997, 11, 1813 DOI
2	Kim, T.; Tolmachev, A. V.; Harkewicz, R.; Prior, D. C.; Anderson, G.; Udseth, H. R.; Smith, R. D. Anal. Chem. 2000, 72, 2247 DOI ScienceOn
3	Kim, T.; Park, M. A. "Ion guide for mass spectrometers", US Patent 7,495,212.
4	Cobb, J. S.; Easterling, M. L.; Agar, J. N. J. Am. Soc. Mass Spectrom. 2010, 21 (6), 949. DOI ScienceOn
5	Dahl, D. A. SIMION 3D (Version 8.1) Idaho National Engineering and Environmental Laboratory; Idaho Falls, ID, 2000.
6	Tolmachev, A. V.; Kim, T.; Udseth, H. R.; Smith, R. D.; Bailey, T. H.; Futrell, J. H. Int. J. Mass Spectrom. 2000, 203, 31. DOI ScienceOn
7	Kim, T. Ph.D. Thesis, 1997, p154, McGill University.