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http://dx.doi.org/10.5478/MSL.2012.3.2.29

Gas Chromatography-High Resolution Tandem Mass Spectrometry Using a GC-APPI-LIT Orbitrap for Complex Volatile Compounds Analysis  

Lee, Young-Jin (Department of Chemistry, Iowa State University)
Smith, Erica A. (Department of Chemistry, Iowa State University)
Jun, Ji-Hyun (Department of Chemistry, Iowa State University)
Publication Information
Mass Spectrometry Letters / v.3, no.2, 2012 , pp. 29-38 More about this Journal
Abstract
A new approach of volatile compounds analysis is proposed using a linear ion trap Orbitrap mass spectrometer coupled with gas chromatography through an atmospheric pressure photoionization interface. In the proposed GC-HRMS/MS approach, direct chemical composition analysis is made for the precursor ions in high resolution MS spectra and the structural identifications were made through the database search of high quality MS/MS spectra. Successful analysis of a complex perfume sample was demonstrated and compared with GC-EI-Q and GC-EI-TOF. The current approach is complementary to conventional GC-EI-MS analysis and can identify low abundance co-eluting compounds. Toluene co-sprayed as a dopant through API probe significantly enhanced ionization of certain compounds and reduced oxidation during the ionization.
Keywords
Gas chromatography; Atmospheric pressure photoionization (APPI); Linear ion trap (LIT); Orbitrap; Volatile compounds;
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