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http://dx.doi.org/10.4283/JMAG.2013.18.2.142

Clinical Application of MRI in an Animal Bone Graft Model  

Liu, Xiaochen (Medical Imaging Center, the Second Affiliated Hospital, Xinjiang Medical University)
Jia, Wenxiao (Medical Imaging Center, the Second Affiliated Hospital, Xinjiang Medical University)
Jin, Gele (Department of Spine Surgery, the First Affiliated Hospital, Xinjiang Medical University)
Wang, Hong (Medical Imaging Center, the Second Affiliated Hospital, Xinjiang Medical University)
Ma, Jingxu (Medical Imaging Center, the Second Affiliated Hospital, Xinjiang Medical University)
Wang, Yunling (Medical Imaging Center, the Second Affiliated Hospital, Xinjiang Medical University)
Yang, Yi (Department of Spine Surgery, the First Affiliated Hospital, Xinjiang Medical University)
Deng, Wei (Department of Spine Surgery, the First Affiliated Hospital, Xinjiang Medical University)
Publication Information
Journal of Magnetics / v.18, no.2, 2013 , pp. 142-149 More about this Journal
Abstract
We aim to monitor vascularization of early bone perfusion following rabbit lumbar intertransverse bone graft fusion surgery using magnetic resonance imaging assessment. Correlation with graft survival status was evaluated by histological method. Experimental animals were randomly divided into three groups and the model was established by operating bilateral lumbar intertransverse bone graft with different types of bone graft substitute material. The lumbar intertransverse area of three groups of rabbits was scanned via MRI. In addition, histological examinations were performed at the $6^{th}$ week after surgery and the quantitative analysis of the osteogenesis in different grafted area was carried out by an image analysis system. The MRI technique can be used for early postoperative evaluation of vascularized bone graft perfusion after transplantation of different bone materials, whereas histological examination allows direct visualization of the osteogenesis process.
Keywords
magnetic resonance imaging; bone graft; vascularization; histology;
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1 X. M. Wang, G. X. Pei, D. Jin, K. H. Wei, C. Jiang, and G. H. Tang, Chin. J. Exp. Surg. 23, 1510 (2006).
2 D. Logeart-Avramoglou, F. Anagnostou, R. Bizios, and H. Petite, J. Cell Mol. Med. 9, 72 (2005).   DOI   ScienceOn
3 R. E. Guldberg, Medical Devices & Surgical Technology Week. 20, 350 (2005).
4 A. R. Padhani and A. Dzik-Jurasz, Top Magn Reson Imaging 15, 41 (2004).   DOI   ScienceOn
5 J. L. Montazel, M. Divine, E. Lepage, H. Kobeiter, S. Breil, and A. Rahmouni, Radiology 229, 703 (2003).   DOI   ScienceOn
6 G. Brix, F. Kiessling, R. Lucht, S. Darai, K. Wasser, S. Delorme, and J. Griebel, Magn Reson Med. 52, 420 (2004).   DOI   ScienceOn
7 S. B. Wedam, J. A. Low, S. X. Yang, C. K. Chow, P. Choyke, D. Danforth, S. M. Hewitt, A. Berman, S. M. Steinberg, D. J. Liewehr, J. Plehn, A. Doshi, D. Thomasson, N. McCarthy, H. Koeppen, M. Sherman, J. Zujewski, K. Camphausen, H. Chen, and S. M. Swain, J. Clin. Oncol. 24, 769 (2006).   DOI   ScienceOn
8 A. C. Lockhart, M. L. Rothenberg, J. Dupont, W. Cooper, P. Chevalier, L. Sternas, G. Buzenet, E. Koehler, J. A. Sosman, L. H. Schwartz, D. H. Gultekin, J. A. Koutcher, E. F. Donnelly, R. Andal, I. Dancy, D. R. Spriggs, and W. P. Tew, J. Clin. Oncol. 28, 207 (2010).   DOI   ScienceOn
9 M. K. Gule, Y. Chen, D. Sano, M. J. Frederick, G. Zhou, M. Zhao, Z. L. Milas, C. E. Galer, Y. C. Henderson, S. A. Jasser, D. L. Schwartz, J. A. Bankson, J. N. Myers, and S. Y. Lai, Clin. Cancer Res. 17, 2281 (2011).   DOI   ScienceOn
10 C. S. van Rijswijk, M. J. Geirnaerdt, P. C. Hogendoorn, J. L. Peterse, F. van Coevorden, A. H. Taminiau, R. A. Tollenaar, B. B. Kroon, and J. L. Bloem, Eur. Radiol. 13, 1849 (2003).   DOI   ScienceOn
11 J. P. Dyke, D. M. Panicek, J. H. Healey, P. A. Meyers, A. G. Huvos, L. H. Schwartz, H. T. Thaler, P. S. Tofts, R. Gorlick, J. A. Koutcher, and D. Ballon, Radiology 228, 271 (2003).   DOI   ScienceOn
12 J. F. Meng, Y. C. Lv, and F. H. Lv, Chinese Journal of Radiology 35, 578 (2001).
13 N. Ehrhart, S. Kraft, D. Conover, R. N. Rosier, and E. M. Schwarz, Clin. Orthop. Relat. Res. 466, 1897 (2008).   DOI   ScienceOn
14 Z. H. Dailiana, V. Zachos, S. Varitimidis, P. Papanagiotou, A. Karantanas, and K. N. Malizos, Eur. J. Radiol. 50, 217 (2004).   DOI   ScienceOn
15 L. K. Cheung and L. W. Zheng, J. Craniofac. Surg. 17, 100 (2006).   DOI   ScienceOn
16 S. S. Liao, K. Guan, Cui FZ, S. S. Shi, and T. S. Sun, Spine (Phila Pa 1976). 28, 1954 (2003).   DOI   ScienceOn
17 J. K. Burkus, M.F Gornet, C. A. Dickman, and T. A. Zdeblick, J. Spinal. Disord. Tech. 15, 337 (2002).   DOI
18 S. D. Boden, J. Kang, H. Sandhu, and J. G. Heller, Spine (Phila Pa 1976). 27, 2662 (2002).   DOI   ScienceOn
19 A. Minamide, T. Tamaki, M. Kawakami, H. Hashizume, M. Yoshida, and R. Sakata, Spine (Phila Pa 1976). 24, 1863 (1999).   DOI   ScienceOn
20 C. A. Vacanti, W. Kim, J. Upton, D. Mooney, and J. P. Vacanti, Tissue Eng. 1, 301 (1995).   DOI
21 E. E. Johnson, M. R. Urist, and G. A. Finerman, Clin. Orthop. Relat. Res. 250, 234 (1990).