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http://dx.doi.org/10.4283/JMAG.2006.11.4.189

Substrate-free Biosensing using Brownian Rotation of Bio-conjugated Magnetic Nanoparticles  

Chung Seok-Hwan (Materials Science Division)
Hoffmann Axel (Materials Science Division)
Chen, Liaohai (Bioscience Division, Argonne National Laboratory)
Sun, Shouheng (Department of Chemistry, Brown University)
Guslienko Konstantin (Materials Science Division)
Grimsditch Marcos (Materials Science Division)
Bader Samuel D. (Materials Science Division)
Publication Information
Journal of Magnetics / v.11, no.4, 2006 , pp. 189-194 More about this Journal
Abstract
The recent development of bio-conjugated magnetic nanoparticles offers many opportunities for applications in the field of biomedicine. In particular, the use of magnetic nanoparticles for biosensing has generated widespread research efforts following the progress of various magnetic field sensors. Here we demonstrate substrate-free biosensing approaches based on the Brownian rotation of ferromagnetic nanoparticles suspended in liquids. The signal transduction is through the measurement of the magnetic ac susceptibility as a function of frequency, whose peak position changes due to the modification of the hydrodynamic radius of bio-conjugated magnetic nanoparticles upon binding to target bio-molecules. The advantage of this approach includes its relative simplicity and integrity compared to methods that use substrate-based stray-field detectors.
Keywords
ac susceptibility; Brownian relaxation; magnetic nanoparticle; biomagnetic sensor;
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