Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity |
Lee, Seunghyeong
(Department of Biomedical Science, Graduate School, Kyungpook National University)
Byun, Jun-Kyu (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University) Kim, Na-Young (Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital) Jin, Jonghwa (Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital) Woo, Hyein (Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital) Choi, Yeon-Kyung (Research Institute of Aging and Metabolism, Kyungpook National University) Park, Keun-Gyu (Department of Biomedical Science, Graduate School, Kyungpook National University) |
1 | Guo C, Sun L, Chen X and Zhang D (2013) Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 8, 2003-2014 |
2 | Ni HM, Williams JA, Jaeschke H and Ding WX (2013) Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biol 1, 427-432 DOI |
3 | Cohen M, Lippman M and Chabner B (1978) Role of pineal gland in aetiology and treatment of breast cancer. Lancet 2, 814-816 DOI |
4 | Jung B and Ahmad N (2006) Melatonin in cancer management: progress and promise. Cancer Res 66, 9789-9793 DOI |
5 | Salmond RJ (2018) mTOR regulation of glycolytic metabolism in T cells. Front Cell Dev Biol 6, 122 |
6 | Park JW, Hwang MS, Suh SI and Baek WK (2009) Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. J Pineal Res 46, 415-421 DOI |
7 | Lee S, Byun JK, Park M et al (2020) Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2. Exp Ther Med 19, 3454-3460 |
8 | Fernandez-Gil BI, Guerra-Librero A, Shen YQ et al (2019) Melatonin enhances cisplatin and radiation cytotoxicity in head and neck squamous cell carcinoma by stimulating mitochondrial ros generation, apoptosis, and autophagy. Oxid Med Cell Longev 2019, 7187128 |
9 | Luchetti F, Canonico B, Betti M et al (2010) Melatonin signaling and cell protection function. Faseb j 24, 3603-3624 DOI |
10 | Yecies JL and Manning BD (2011) Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res 71, 2815-2820 DOI |
11 | Li ZY, Yang Y, Ming M and Liu B (2011) Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem Biophys Res Commun 414, 5-8 DOI |
12 | Csibi A, Lee G, Yoon SO et al (2014) The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr Biol 24, 2274-2280 DOI |
13 | Bonello S, Zahringer C, BelAiba RS et al (2007) Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol 27, 755-761 DOI |
14 | Gonzalez A, Estaras M, Martinez-Morcillo S and Martinez R (2020) Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells. Sci Rep 10, 6352 |
15 | Loureiro R, Magalhaes-Novais S, Mesquita KA et al (2015) Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells. Oncotarget 6, 17081-17096 DOI |
16 | DeBerardinis RJ, Lum JJ, Hatzivassiliou G and Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11-20 DOI |
17 | Hevia D, Gonzalez-Menendez P, Fernandez-Fernandez M, Cueto S and Rodriguez-Gonzalez P (2017) Melatonin decreases glucose metabolism in prostate cancer cells: A (13)C stable isotope-resolved metabolomic study. Int J Mol Sci 18, 162 |
18 | Park SY, Jang WJ, Yi EY et al (2010) Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia. J Pineal Res 48, 178-184 DOI |
19 | Ferreira GM, Martinez M, Camargo IC, Domeniconi RF, Martinez FE and Chuffa LG (2014) Melatonin attenuates Her-2, p38 MAPK, p-AKT, and mTOR levels in ovarian carcinoma of ethanol-preferring rats. J Cancer 5, 728-735 DOI |
20 | Ben-Sahra I and Manning BD (2017) mTORC1 signaling and the metabolic control of cell growth. Curr Opin Cell Biol 45, 72-82 DOI |
21 | Sarti P, Magnifico MC, Altieri F, Mastronicola D and Arese M (2013) New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide. Int J Mol Sci 14, 11259-11276 DOI |
22 | Mehrzadi S, Pourhanifeh MH, Mirzaei A, Moradian F and Hosseinzadeh A (2021) An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress. Cancer Cell Int 21, 188 |
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