IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling |
Kim, Inyoung
(Department of Pharmacology, Chonnam National University Medical School)
Kim, Jung Ha (Department of Pharmacology, Chonnam National University Medical School) Kim, Kabsun (Department of Pharmacology, Chonnam National University Medical School) Seong, Semun (Department of Pharmacology, Chonnam National University Medical School) Lee, Keun-Bae (Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital) Kim, Nacksung (Department of Pharmacology, Chonnam National University Medical School) |
1 | Kang IS and Kim C (2016) NADPH oxidase gp91(phox) contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1. Sci Rep 6, 38014 DOI |
2 | Franzoso G, Carlson L, Xing L et al (1997) Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11, 3482-3496 DOI |
3 | Lee HI, Lee GR, Lee J et al (2020) Dehydrocostus lactone inhibits NFATc1 via regulation of IKK, JNK, and Nrf2, thereby attenuating osteoclastogenesis. BMB Rep 53, 218-222 DOI |
4 | Takatsuna H, Asagiri M, Kubota T et al (2005) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res 20, 653-662 DOI |
5 | Abu-Amer Y (2013) NF-κB signaling and bone resorption. Osteoporos Int 24, 2377-2386 DOI |
6 | Kim I, Kim JH, Kim K, Seong S and Kim N (2017) Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1. BMB Rep 50, 454-459 DOI |
7 | Boyle WJ, Simonet WS and Lacey DL (2003) Osteoclast differentiation and activation. Nature 423, 337-342 DOI |
8 | Kim JH and Kim N (2014) Regulation of NFATc1 in osteoclast differentiation. J Bone Metab 21, 233-241 DOI |
9 | Kim JH and Kim N (2016) Signaling pathways in osteoclast differentiation. Chonnam Med J 52, 12-17 DOI |
10 | Asagiri M, Sato K, Usami T et al (2005) Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202, 1261-1269 DOI |
11 | Takayanagi H, Kim S, Koga T et al (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3, 889-901 DOI |
12 | Solt LA and May MJ (2008) The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res 42, 3-18 DOI |
13 | Hayden MS and Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18, 2195-2224 DOI |
14 | Novack DV, Yin L, Hagen-Stapleton A et al (2003) The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis. J Exp Med 198, 771-781 DOI |
15 | Iotsova V, Caamano J, Loy J, Yang Y, Lewin A and Bravo R (1997) Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3, 1285-1289 DOI |
16 | Boyce BF, Xiu Y, Li J, Xing L and Yao Z (2015) NF-κB-mediated regulation of osteoclastogenesis. Endocrinol Metab (Seoul) 30, 35-44 DOI |
17 | Vaira S, Johnson T, Hirbe AC et al (2008) RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci U S A 105, 3897-3902 DOI |
18 | Yanai H, Negishi H and Taniguchi T (2012) The IRF family of transcription factors: inception, impact and implications in oncogenesis. Oncoimmunology 1, 1376-1386 DOI |
19 | Masumi A, Fukazawa H, Shimazu T et al (2006) Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncogene 25, 5113-5124 DOI |
20 | Masumi A, Yamakawa Y, Fukazawa H, Ozato K and Komuro K (2003) Interferon regulatory factor-2 regulates cell growth through its acetylation. J Biol Chem 278, 25401-25407 DOI |
21 | Luo W and Skalnik DG (1996) Interferon regulatory factor-2 directs transcription from the gp91phox promoter. J Biol Chem 271, 23445-23451 DOI |
22 | Jesse TL, LaChance R, Iademarco MF and Dean DC (1998) Interferon regulatory factor-2 is a transcriptional activator in muscle where It regulates expression of vascular cell adhesion molecule-1. J Cell Biol 140, 1265-1276 DOI |
23 | Zhao B, Takami M, Yamada A et al (2009) Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 15, 1066-1071 DOI |
24 | Nakashima Y and Haneji T (2013) Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss. PLoS One 8, e72033 DOI |
25 | Salem S, Gao C, Li A et al (2014) A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism. J Cell Mol Med 18, 1588-1598 DOI |
26 | Muhammad K, Alrefai H, Marienfeld R et al (2014) NF-κB factors control the induction of NFATc1 in B lymphocytes. Eur J Immunol 44, 3392-3402 DOI |
27 | Kim I, Kim JH, Kim K, Seong S and Kim N (2019) The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation. BMB Rep 52, 469-474 DOI |
28 | Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289, 1504-1508 DOI |
29 | Zhao GN, Jiang DS and Li H (2015) Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease. Biochim Biophys Acta 1852, 365-378 DOI |
30 | Ge X, Jin Q, Zhang F, Yan T and Zhai Q (2009) PCAF acetylates {beta}-catenin and improves its stability. Mol Biol Cell 20, 419-427 DOI |
31 | Ihn HJ, Kim TH, Kim K et al (2019) 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-βκ-D-glucose isolated from Galla Rhois suppresses osteoclast differentiation and function by inhibiting NF-κB signaling. BMB Rep 52, 409-414 DOI |
32 | Alsamman K and El-Masry OS (2018) Interferon regulatory factor 1 inactivation in human cancer. Biosci Rep 38, 1-14 |
33 | Chae M, Kim K, Park SM et al (2008) IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB. Biochem Biophys Res Commun 370, 519-524 DOI |
![]() |