Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients |
Yoo, Hyun Kyu
(Department of Ophthalmology, Ajou University School of Medicine)
Park, Hyunju (Department of Physiology, Inflammation-Cancer Microenvironment Research Center, Ewha Womans University School of Medicine) Hwang, Hye Suk (Department of Ophthalmology, Ajou University School of Medicine) Kim, Hee Ja (Department of Physiology, Inflammation-Cancer Microenvironment Research Center, Ewha Womans University School of Medicine) Choi, Youn-Hee (Department of Physiology, Inflammation-Cancer Microenvironment Research Center, Ewha Womans University School of Medicine) Kook, Koung Hoon (Department of Ophthalmology, Ajou University School of Medicine) |
1 | Wong YK, Tang KT, Wu JC, Hwang JJ and Wang HS (2001) Stimulation of hyaluronan synthesis by interleukin-1beta involves activation of protein kinase C betaII in fibroblasts from patients with Graves' ophthalmopathy. J Cell Biochem 82, 58-67 DOI |
2 | Wang HS, Tung WH, Tang KT et al (2005) TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro. J Cell Biochem 95, 256-267 DOI |
3 | Svennerholm L (1964) The Gangliosides. J Lipid Res 5, 145-155 DOI |
4 | Nakamura K, Inagaki F and Tamai Y (1988) A novel ganglioside in dogfish brain. Occurrence of a trisialoganglioside with a sialic acid linked to N-acetylgalactosamine. J Biol Chem 263, 9896-9900 DOI |
5 | Yu RK, Tsai YT, Ariga T and Yanagisawa M (2011) Structures, biosynthesis, and functions of gangliosides--an overview. J Oleo Sci 60, 537-544 DOI |
6 | Huwiler A, Kolter T, Pfeilschifter J and Sandhoff K (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 1485, 63-99 DOI |
7 | Kook KH, Choi YH, Kim YR et al (2011) Altered ganglioside expression modulates the pathogenic mechanism of thyroid-associated ophthalmopathy by increase in hyaluronic acid. Invest Ophthalmol Vis Sci 52, 264-273 DOI |
8 | Korducki JM, Loftus SJ and Bahn RS (1992) Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts. Invest Ophthalmol Vis Sci 33, 2037-2042 |
9 | Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657 DOI |
10 | Yoon HJ, Jeon SB, Suk K, Choi DK, Hong YJ and Park EJ (2008) Contribution of TLR2 to the initiation of ganglioside-triggered inflammatory signaling. Mol Cells 25, 99-104 |
11 | Liu YD, Ji CB, Li SB et al (2018) Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-kappaB signaling pathways. Int Immunopharmacol 59, 375-383 DOI |
12 | Lim ST, Esfahani K, Avdoshina V and Mocchetti I (2011) Exogenous gangliosides increase the release of brain-derived neurotrophic factor. Neuropharmacology 60, 1160-1167 DOI |
13 | Kanda N and Tamaki K (1999) Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. Immunology 96, 628-633 DOI |
14 | Kanda N and Watanabe S (2001) Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutininstimulated human T cells. J Immunol 166, 72-80 DOI |
15 | Hsieh AC, Truitt ML and Ruggero D (2011) Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer 105, 329-336 DOI |
16 | Xu J and Liao K (2004) Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem 279, 35914-35922 DOI |
17 | Juric D, Krop I, Ramanathan RK et al (2017) Phase I dose-escalation study of taselisib, an oral pi3k inhibitor, in patients with advanced solid tumors. Cancer Discov 7, 704-715 DOI |
18 | Dreyling M, Santoro A, Mollica L et al (2017) Phosphatidylinositol 3-Kinase Inhibition by copanlisib in relapsed or refractory indolent lymphoma. J Clin Oncol 35, 3898-3905 DOI |
19 | Raphael J, Desautels D, Pritchard KI, Petkova E and Shah PS (2018) Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis. Eur J Cancer 91, 38-46 DOI |
20 | Zhang L, Grennan-Jones F, Lane C, Rees DA, Dayan CM and Ludgate M (2012) Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. J Clin Endocrinol Metab 97, 653-662 DOI |
21 | Kumar S, Nadeem S, Stan MN, Coenen M and Bahn RS (2011) A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy. J Mol Endocrinol 46, 155-163 DOI |
22 | Li B and Smith TJ (2014) PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN. J Clin Endocrinol Metab 99, 3363-3372 DOI |
23 | Thaiss CA, Levy M, Itav S and Elinav E (2016) Integration of Innate Immune Signaling. Trends Immunol 37, 84-101 DOI |
24 | Kawasaki T and Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5, 461 |
25 | Pasonen-Seppanen S, Takabe P, Edward M et al (2012) Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFRPI3K-AKT and p38 signaling. Histochem Cell Biol 138, 895-911 DOI |
26 | Lim HS, Back KO, Kim HJ, Choi YH, Park YM and Kook KH (2014) Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated ophthalmopathy. Invest Ophthalmol Vis Sci 55, 7441-7450 DOI |
27 | Kaback LA and Smith TJ (1999) Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 84, 4079-4084 DOI |
28 | Zhang L, Bowen T, Grennan-Jones F et al (2009) Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction. J Biol Chem 284, 26447-26455 DOI |
29 | Qin J, Berdyshev E, Poirer C, Schwartz NB and Dawson G (2012) Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem 287, 13620-13632 DOI |
30 | Kultti A, Karna R, Rilla K et al (2010) Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt. J Biol Chem 285, 22901-22910 DOI |
31 | Manning BD and Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 DOI |
32 | Bahn RS (2010) Graves' ophthalmopathy. N Engl J Med 362, 726-738 DOI |
33 | Kazim M, Goldberg RA and Smith TJ (2002) Insights into the pathogenesis of thyroid-associated orbitopathy: evolving rationale for therapy. Arch Ophthalmol 120, 380-386 DOI |
34 | Garrity JA and Bahn RS (2006) Pathogenesis of graves ophthalmopathy: implications for prediction, prevention, and treatment. Am J Ophthalmol 142, 147-153 DOI |
35 | Naik VM, Naik MN, Goldberg RA, Smith TJ and Douglas RS (2010) Immunopathogenesis of thyroid eye disease: emerging paradigms. Surv Ophthalmol 55, 215-226 DOI |
36 | Smith TJ, Bahn RS and Gorman CA (1989) Connective tissue, glycosaminoglycans, and diseases of the thyroid. Endocr Rev 10, 366-391 DOI |
37 | Schulz T, Schumacher U and Prehm P (2007) Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem 282, 20999-21004 DOI |
38 | Hansen C, Rouhi R, Forster G and Kahaly GJ (1999) Increased sulfatation of orbital glycosaminoglycans in Graves' ophthalmopathy. J Clin Endocrinol Metab 84, 1409-1413 DOI |
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