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http://dx.doi.org/10.5483/BMBRep.2020.53.8.087

Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes  

de Almeida, Bruna Oliveira (Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo)
Machado-Neto, Joao Agostinho (Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo)
Publication Information
BMB Reports / v.53, no.8, 2020 , pp. 413-418 More about this Journal
Abstract
ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions and regulate fundamental biological processes, while the KH domain binds to RNA or ssDNA and is associated with transcriptional and translational regulation. In recent years, studies containing relevant information on ANKHD1 in cancer biology and its clinical relevance, as well as the increasing complexity of signaling networks in which this protein acts, have been reported. Among the signaling pathways of interest in oncology regulated by ANKHD1 are Hippo signaling, JAK/STAT, and STMN1. The scope of the present review is to survey the current knowledge and highlight future perspectives for ANKHD1 in the malignant phenotype of cancer cells, exploring biological, functional, and clinical reports of this protein in cancer.
Keywords
ANKHD1; Ankyrin repeat and KH domain containing 1; Cancer; JAK/STAT; YAP1;
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