The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation |
Kim, Inyoung
(Department of Pharmacology, Chonnam National University Medical School)
Kim, Jung Ha (Department of Pharmacology, Chonnam National University Medical School) Kim, Kabsun (Department of Pharmacology, Chonnam National University Medical School) Seong, Semun (Department of Pharmacology, Chonnam National University Medical School) Kim, Nacksung (Department of Pharmacology, Chonnam National University Medical School) |
1 | Leibbrandt A and Penninger JM (2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci 1143, 123-150 DOI |
2 | Kim JH and Kim N (2016) Signaling Pathways in Osteoclast Differentiation. Chonnam Med J 52, 12-17 DOI |
3 | Takayanagi H, Kim S, Koga T et al (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3, 889-901 DOI |
4 | Katagiri T and Takahashi N (2002) Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 8, 147-159 DOI |
5 | Matsubara T, Kida K, Yamaguchi A et al (2008) BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 283, 29119-29125 DOI |
6 | Schroeder TM, Jensen ED and Westendorf JJ (2005) Runx2: a master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res C Embryo Today 75, 213-225 DOI |
7 | Boyce BF, Yao Z and Xing L (2010) Functions of nuclear factor kappaB in bone. Ann N Y Acad Sci 1192, 367-375 DOI |
8 | Kim I, Kim JH, Kim K, Seong S and Kim N (2017) Tusc2/Fus1 regulates osteoclast differentiation through NF-kappaB and NFATc1. BMB Rep 50, 454-459 DOI |
9 | Bak SU, Kim S, Hwang HJ et al (2017) Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-kappaB activation. BMB Rep 50, 103-108 DOI |
10 | Yamashita T, Yao Z, Li F et al (2007) NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem 282, 18245-18253 DOI |
11 | Nayak L, Goduni L, Takami Y et al (2013) Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am J Pathol 182, 1696-1704 DOI |
12 | Yamazaki M, Fukushima H, Shin M et al (2009) Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB. J Biol Chem 284, 35987-35995 DOI |
13 | Yao Z, Li Y, Yin X, Dong Y, Xing L and Boyce BF (2014) NF-kappaB RelB negatively regulates osteoblast differentiation and bone formation. J Bone Miner Res 29, 866-877 DOI |
14 | Lee J, Youn BU, Kim K et al (2015) Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation. J Bone Miner Res 30, 1597-1607 DOI |
15 | Childs KS and Goodbourn S (2003) Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. Nucleic Acids Res 31, 3016-3026 DOI |
16 | Dang DT, Pevsner J and Yang VW (2000) The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol 32, 1103-1121 DOI |
17 | Das H, Kumar A, Lin Z et al (2006) Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A 103, 6653-6658 DOI |
18 | Das M, Lu J, Joseph M et al (2012) Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1beta-induced arthritis. Curr Mol Med 12, 113-125 DOI |
19 | Carneiro FR, Ramalho-Oliveira R, Mognol GP and Viola JP (2011) Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. Mol Cell Biol 31, 2889-2901 DOI |
20 | Teng AC, Kuraitis D, Deeke SA et al (2010) IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J 24, 4825-4834 DOI |
21 | Cao Z, Sun X, Icli B, Wara AK and Feinberg MW (2010) Role of Kruppel-like factors in leukocyte development, function, and disease. Blood 116, 4404-4414 DOI |
22 | Chen HH, Keyhanian K, Zhou X et al (2015) IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis. Circ Res 117, 671-683 DOI |
23 | Jha P and Das H (2017) KLF2 in Regulation of NF-kappaB-Mediated Immune Cell Function and Inflammation. Int J Mol Sci 18, 2383-2420 DOI |
24 | SenBanerjee S, Lin Z, Atkins GB et al (2004) KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med 199, 1305-1315 DOI |
25 | Boyce BF, Xiu Y, Li J, Xing L and Yao Z (2015) NF-kappaB-Mediated Regulation of Osteoclastogenesis. Endocrinol Metab (Seoul) 30, 35-44 DOI |
26 | Chang J, Wang Z, Tang E et al (2009) Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 15, 682-689 DOI |
27 | Zhang H and Reilly MP (2015) IRF2BP2: A New Player at the Crossroads of Inflammation and Lipid Metabolism. Circ Res 117, 656-658 DOI |
28 | Zhou B, Cron RQ, Wu B et al (2002) Regulation of the murine Nfatc1 gene by NFATc2. J Biol Chem 277, 10704-10711 DOI |
29 | Ikeda F, Nishimura R, Matsubara T et al (2004) Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114, 475-484 DOI |
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