Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges |
Dayem, Ahmed Abdal
(Department of Stem Cell & Regenerative Biotechnology, Konkuk University)
Lee, Soo Bin (Department of Stem Cell & Regenerative Biotechnology, Konkuk University) Kim, Kyeongseok (Department of Stem Cell & Regenerative Biotechnology, Konkuk University) Lim, Kyung Min (Department of Stem Cell & Regenerative Biotechnology, Konkuk University) Jeon, Tak-il (Department of Stem Cell & Regenerative Biotechnology, Konkuk University) Cho, Ssang-Goo (Department of Stem Cell & Regenerative Biotechnology, Konkuk University) |
1 | Posselt AM, Szot GL, Frassetto LA et al (2010) Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation 90, 1595-1601 DOI |
2 | Barton FB, Rickels MR, Alejandro R et al (2012) Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 35, 1436-1445 DOI |
3 | Shapiro AMJ, Ricordi C, Hering BJ et al (2006) International trial of the edmonton protocol for islet transplantation. N Engl J Med 355, 1318-1330 DOI |
4 |
Russ HA, Bar Y, Ravassard P and Efrat S (2008) In vitro proliferation of cells derived from adult human |
5 | Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B and Raaka BM (2004) Epithelial-tomesenchymal transition generates proliferative human islet precursor cells. Science 306, 2261-2264 DOI |
6 | Dominguez-Bendala J, Inverardi L and Ricordi C (2011) Stem cell-derived islet cells for transplantation. Curr Opin Organ Transplant 16, 76 DOI |
7 | D'Amour KA, Bang AG, Eliazer S et al (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24, 1392 DOI |
8 | Shim J, Kim S, Woo D et al (2007) Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 50, 1228-1238 DOI |
9 |
Shahjalal HM, Dayem AA, Lim KM, Jeon T-i and Cho S-G (2018) Generation of pancreatic |
10 | Rezania A, Bruin JE, Arora P et al (2014) Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol 32, 1121-1133 DOI |
11 | Todorov I, Omori K, Pascual M et al (2006) Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 32, 130-138 DOI |
12 | Rezania A, Bruin JE, Riedel MJ et al (2012) Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes 61, 2016-2029 DOI |
13 | Mummery C (2011) Induced pluripotent stem cells-a cautionary note. N Engl J Med 364, 2160-2162 DOI |
14 | Seeberger KL, Dufour JM, Shapiro AMJ, Lakey JR, Rajotte RV and Korbutt GS (2006) Expansion of mesenchymal stem cells from human pancreatic ductal epithelium. Laboratory Investigation 86, 141 DOI |
15 | McCauley HA and Wells JM (2017) Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development 144, 958-962 DOI |
16 | Cortijo C, Gouzi M, Tissir F and Grapin-Botton A (2012) Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep 2, 1593-1606 DOI |
17 | Dutta D, Heo I and Clevers H (2017) Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends Mol Med 23, 393-410 DOI |
18 | Liu C, Oikonomopoulos A, Sayed N and Wu JC (2018) Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. Development 145, dev156166 DOI |
19 | Sato T, Vries RG, Snippert HJ et al (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262 DOI |
20 | Eiraku M, Takata N, Ishibashi H et al (2011) Selforganizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51 DOI |
21 | Takasato M, Pei XE, Chiu HS et al (2015) Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564 DOI |
22 | Huch M, Dorrell C, Boj SF et al (2013) In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 494, 247 DOI |
23 | Lancaster MA, Renner M, Martin C-A et al (2013) Cerebral organoids model human brain development and microcephaly. Nature 501, 373 DOI |
24 | Spence JR, Mayhew CN, Rankin SA et al (2011) Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105 DOI |
25 | Chua CW, Shibata M, Lei M et al (2014) Single luminal epithelial progenitors can generate prostate organoids in culture. Nat Cell Biol 16, 951 DOI |
26 | Dye BR, Hill DR, Ferguson MA et al (2015) In vitro generation of human pluripotent stem cell derived lung organoids. Elife 4, e05098 DOI |
27 | Benitez CM, Goodyer WR and Kim SK (2012) Deconstructing pancreas developmental biology. Cold Spring Harb Perspect Biol 4, 1-17 |
28 | Puri S and Hebrok M (2010) Cellular plasticity within the pancreas--lessons learned from development. Dev Cell 18, 342-356 DOI |
29 | Spagnoli FM (2007) From endoderm to pancreas: a multistep journey. Cell Mol Life Sci 64, 2378-2390 DOI |
30 | Pan FC and Wright C (2011) Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 240, 530-565 DOI |
31 | Villasenor A, Chong DC, Henkemeyer M and Cleaver O (2010) Epithelial dynamics of pancreatic branching morphogenesis. Development 137, 4295-4305 DOI |
32 | Seymour PA, Freude KK, Tran MN et al (2007) SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A 104, 1865-1870 DOI |
33 | Greggio C, De Franceschi F, Figueiredo-Larsen M et al (2013) Artificial three-dimensional niches deconstruct pancreas development in vitro. Development 140, 4452-4462 DOI |
34 | Gu G, Dubauskaite J and Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457 DOI |
35 | Kopp JL, Dubois CL, Schaffer AE et al (2011) Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138, 653-665 DOI |
36 | Kobberup S, Schmerr M, Dang ML et al (2010) Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10. Mech Dev 127, 220-234 DOI |
37 | Hald J, Hjorth JP, German MS, Madsen OD, Serup P and Jensen J (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 260, 426-437 DOI |
38 | Murtaugh LC, Stanger BZ, Kwan KM and Melton DA (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100, 14920-14925 DOI |
39 | Takahashi Y, Takebe T and Taniguchi H (2018) Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation. Curr Protoc Stem Cell Biol 45, 4 |
40 | Takahashi Y, Takebe T and Taniguchi H (2016) Engineering pancreatic tissues from stem cells towards therapy. Regen Ther 3, 15-23 DOI |
41 | Takebe T, Enomura M, Yoshizawa E et al (2015) Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation. Cell Stem Cell 16, 556-565 DOI |
42 | Li W, Nakanishi M, Zumsteg A et al (2014) In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife 1, 01846 |
43 | Finkbeiner SR, Hill DR, Altheim CH et al (2015) Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports 3, 00122-00128 |
44 | Loomans CJM, Williams Giuliani N, Balak J et al (2018) Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential. Stem Cell Reports 10, 712-724 DOI |
45 | Zhou Q, Brown J, Kanarek A, Rajagopal J and Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 DOI |
46 | Jiang K, Chaimov D, Patel SN et al (2019) 3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture. Biomaterials 198, 37-48 DOI |
47 | Hindley CJ, Cordero-Espinoza L and Huch M (2016) Organoids from adult liver and pancreas: Stem cell biology and biomedical utility. Dev Biol 420, 251-261 DOI |
48 | Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT and Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol 33, 1193-1200 DOI |
49 | Shim JH, Kim J, Han J et al (2015) Pancreatic Islet-Like Three-Dimensional Aggregates Derived From Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Cell Transplant 24, 2155-2168 DOI |
50 | Azzarelli R, Rulands S, Nestorowa S et al (2018) Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Sci Rep 8, 018-33838 DOI |
51 | Kim Y, Kim H, Ko UH et al (2016) Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo. Sci Rep 6, 35145 DOI |
52 | Jaramillo M, Mathew S, Mamiya H, Goh SK and Banerjee I (2015) Endothelial cells mediate islet-specific maturation of human embryonic stem cell-derived pancreatic progenitor cells. Tissue Eng Part A 21, 14-25 DOI |
53 | Wang X and Ye K (2009) Three-dimensional differentiation of embryonic stem cells into islet-like insulin-producing clusters. Tissue Eng Part A 15, 1941-1952 DOI |
54 | Wang W, Jin S and Ye K (2017) Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds. Stem Cells Dev 26, 394-404 DOI |
55 | Candiello J, Grandhi TSP, Goh SK et al (2018) 3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform. Biomaterials 177, 27-39 DOI |
56 | Pagliuca FW, Millman JR, Gurtler M et al (2014) Generation of functional human pancreatic beta cells in vitro. Cell 159, 428-439 DOI |
57 | Tao T, Wang Y, Chen W et al (2019) Engineering human islet organoids from iPSCs using an organ-on-chip platform. Lab on a Chip 19, 948-958 DOI |
58 | May CL and Kaestner KH (2010) Gut endocrine cell development. Mol Cell Endocrinol 323, 70-75 DOI |
59 | Schonhoff SE, Giel-Moloney M and Leiter AB (2004) Minireview: Development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644 DOI |
60 | McCauley HA and Wells JM (2016) Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin. Cell Stem Cell 18, 295-297 DOI |
61 | Chen YJ, Finkbeiner SR, Weinblatt D et al (2014) De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep 6, 1046-1058 DOI |
62 | Ariyachet C, Tovaglieri A, Xiang G et al (2016) Reprogrammed stomach tissue as a renewable source of functional beta cells for blood glucose regulation. Cell Stem Cell 18, 410-421 DOI |
63 | Talchai SC and Accili D (2015) Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult beta-Cell Mass and Function. Diabetes 64, 2868-2879 DOI |
64 | Bouchi R, Foo KS, Hua H et al (2014) FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures. Nat Commun 5, 1-11 |
65 | Talchai C, Xuan S, Kitamura T, DePinho RA and Accili D (2012) Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44, 406-412 DOI |
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