Browse > Article
http://dx.doi.org/10.5483/BMBRep.2019.52.1.301

Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis  

Bang, EunJin (Department of Pharmacy, College of Pharmacy, Pusan National University)
Lee, Bonggi (Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM))
Noh, Sang-Gyun (Department of Pharmacy, College of Pharmacy, Pusan National University)
Kim, Dae Hyun (Department of Pharmacy, College of Pharmacy, Pusan National University)
Jung, Hee Jin (Department of Pharmacy, College of Pharmacy, Pusan National University)
Ha, Sugyeong (Department of Pharmacy, College of Pharmacy, Pusan National University)
Yu, Byung Pal (Department of Physiology, The University of Texas Health Science Center at San Antonio)
Chung, Hae Young (Department of Pharmacy, College of Pharmacy, Pusan National University)
Publication Information
BMB Reports / v.52, no.1, 2019 , pp. 56-63 More about this Journal
Abstract
Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.
Keywords
Aging; Chronic inflammation; CR; Omics big data; Senoinflammation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chung HY, Cesari M, Anton S et al (2009) Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8, 18-30   DOI
2 Chung HY, Kim DH, Lee EK et al (2018) Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept. Aging Dis [Epub ahead of print]
3 Vasto S, Candore G, Balistreri CR et al (2007) Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 128, 83-91   DOI
4 Yu BP and Yang R (1996) Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. Ann N Y Acad Sci 786, 1-11   DOI
5 Groslambert M and Py BF (2018) Spotlight on the NLRP3 inflammasome pathway. J Inflamm Res 11, 359-374   DOI
6 Hanouna G, Mesnard L, Vandermeersch S et al (2017) Specific calpain inhibition protects kidney against inflammaging. Sci Rep 7, 8016   DOI
7 Baker DJ, Childs BG, Durik M et al (2016) Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530, 184-189   DOI
8 Salminen A, Kauppinen A and Kaarniranta K (2012) Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24, 835-845   DOI
9 Young AR and Narita M (2009) SASP reflects senescence. EMBO Rep 10, 228-230   DOI
10 Coppe JP, Patil CK, Rodier F et al (2008) Senescenceassociated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6, 2853-2868
11 Freund A, Orjalo AV, Desprez PY and Campisi J (2010) Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 16, 238-246   DOI
12 Seo YH, Jung HJ, Shin HT et al (2008) Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell 7, 894-907   DOI
13 Coppe JP, Desprez PY, Krtolica A and Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5, 99-118   DOI
14 Georgilis A, Klotz S, Hanley CJ et al (2018) PTBP1- Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell 34, 85-102.e109   DOI
15 Fuhrmann-Stroissnigg H, Niedernhofer LJ and Robbins PD (2018) Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell Cycle 17, 1048-1055   DOI
16 Redman LM and Ravussin E (2011) Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. Antioxid Redox Signal 14, 275-287   DOI
17 Gonzalez O, Tobia C, Ebersole J and Novak MJ (2012) Caloric restriction and chronic inflammatory diseases. Oral Dis 18, 16-31   DOI
18 Mattson MP, Duan W, Lee J and Guo Z (2001) Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech Ageing Dev 122, 757-778   DOI
19 Anderson RM and Weindruch R (2012) The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol 24, 101-106   DOI
20 Nadon NL, Strong R, Miller RA et al (2008) Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) 30, 187-199   DOI
21 Cohen DE, Supinski AM, Bonkowski MS, Donmez G and Guarente LP (2009) Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev 23, 2812-2817   DOI
22 Pahlavani MA (2000) Caloric restriction and immunosenescence: a current perspective. Front Biosci 5, D580-587
23 Kurki E, Shi J, Martonen E, Finckenberg P and Mervaala E (2012) Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice. Nutr Metab (Lond) 9, 64   DOI
24 Lijnen HR, Van Hul M and Hemmeryckx B (2012) Caloric restriction improves coagulation and inflammation profile in obese mice. Thromb Res 129, 74-79   DOI
25 Choi WH, Um MY, Ahn J, Jung CH and Ha TY (2014) Cooked rice inhibits hepatic fat accumulation by regulating lipid metabolism-related gene expression in mice fed a high-fat diet. J Med Food 17, 36-42   DOI
26 Jung KJ, Lee EK, Kim JY et al (2009) Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Inflamm Res 58, 143-150   DOI
27 Zheng Y, Zhang W, Pendleton E et al (2009) Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats. J Endocrinol 203, 337-347   DOI
28 Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E and Miller RA (2015) Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice. Physiol Rep 3, e12379   DOI
29 Tsutsumi A, Motoshima H, Kondo T et al (2011) Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice. Biochem Biophys Res Commun 404, 339-344   DOI
30 Escriva F, Gavete ML, Fermin Y et al (2007) Effect of age and moderate food restriction on insulin sensitivity in Wistar rats: role of adiposity. J Endocrinol 194, 131-141   DOI
31 Park MH, Park JY, Lee HJ et al (2013) Potent anti-diabetic effects of MHY908, a newly synthesized PPAR alpha/gamma dual agonist in db/db mice. PLoS One 8, e78815   DOI
32 Youm YH, Nguyen KY, Grant RW et al (2015) The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 21, 263-269   DOI
33 Fann DY, Santro T, Manzanero S et al (2014) Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp Neurol 257, 114-119   DOI
34 Traba J, Kwarteng-Siaw M, Okoli TC et al (2015) Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J Clin Invest 125, 4592-4600   DOI
35 Chung KW, Kim DH, Park MH et al (2013) Recent advances in calorie restriction research on aging. Exp Gerontol 48, 1049-1053   DOI
36 Chung SW, Kang BY, Kim SH et al (2000) Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J Biol Chem 275, 32681-32687   DOI
37 Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS and Chung HY (2002) Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 123, 1589-1595   DOI
38 Sung B, Park S, Yu BP and Chung HY (2004) Modulation of PPAR in aging, inflammation, and calorie restriction. J Gerontol A Biol Sci Med Sci 59, 997-1006   DOI
39 Delerive P, Gervois P, Fruchart JC and Staels B (2000) Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 275, 36703-36707   DOI
40 Chung JH, Seo AY, Chung SW et al (2008) Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res Rev 7, 126-136   DOI
41 Satoh A, Brace CS, Rensing N et al (2013) Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab 18, 416-430   DOI
42 Nisoli E, Tonello C, Cardile A et al (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310, 314-317   DOI
43 Frescas D, Valenti L and Accili D (2005) Nuclear trapping of the forkhead transcription factor FoxO1 via Sirtdependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280, 20589-20595   DOI
44 He S and Sharpless NE (2017) Senescence in Health and Disease. Cell 169, 1000-1011   DOI
45 Hong SE, Heo HS, Kim DH et al (2010) Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr) 32, 15-30   DOI
46 Park D, Lee EK, Jang EJ et al (2013) Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome. Age (Dordr) 35, 1045-1060   DOI
47 Park D, Kim BC, Kim CH et al (2016) RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney. Oncotarget 7, 30037-30048   DOI
48 Kim CH, Lee EK, Choi YJ et al (2016) Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation. Aging Cell 15, 1074-1081   DOI
49 Park MH, Kim DH, Lee EK et al (2014) Age-related inflammation and insulin resistance: a review of their intricate interdependency. Arch Pharm Res 37, 1507-1514   DOI
50 Kim DH, Kim JY, Yu BP and Chung HY (2008) The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology 9, 33-47   DOI