Browse > Article
http://dx.doi.org/10.5483/BMBRep.2018.51.5.045

Role of estrogen and RAS signaling in repeated implantation failure  

Hong, Kwonho (Department of Stem Cell and Regenerative Biotechnology, Konkuk University)
Choi, Youngsok (Department of Biomedical Science, CHA University)
Publication Information
BMB Reports / v.51, no.5, 2018 , pp. 225-229 More about this Journal
Abstract
In humans, hormonal regulation is crucial for the preparation of uterine environment leading to either successful implantation or menstrual cycle. Estrogen is a pivotal female steroid hormone that regulates the uterine dynamics along with progesterone in the estrous and menstrual cycles in humans. Estrogen signals act via nuclear estrogen receptor or membrane-bound receptor. The membrane-bound estrogen receptor plays a crucial role in the rapid response of estrogen in the uterine epithelium. Recently, RASD1 has received attention as a novel signal transducer of estrogen in various systems including female reproductive organs. In this review, we discuss the regulation of estrogen and RASD1 signaling in the uterus and also provide insights into RAS as a novel signaling molecule in repeated implantation failure.
Keywords
Estrogen; Estrogen receptor; RAS signaling; Repeated implantation failure; Uterus;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Groothuis PG, Dassen HH, Romano A and Punyadeera C (2007) Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human. Hum Reprod Update 13, 405-417   DOI
2 Champlin AK, Dorr DL and Gates AH (1973) Determining the stage of the estrous cycle in the mouse by the appearance of the vagina. Biol Reprod 8, 491-494   DOI
3 Wang H and Dey SK (2006) Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet 7, 185-199   DOI
4 Cunha GR and Lung B (1979) The importance of stroma in morphogenesis and functional activity of urogenital epithelium. In Vitro 15, 50-71   DOI
5 Agarwal AK, Durani S and Setty BS (1982) Dose dependent modulation of receptor dynamics and uterine growth in immature rat by estradiol: importance of an additional nuclear binding at 24 hr for long-term (72 hr) uterine growth. Endokrinologie 79, 235-241
6 Bondesson M, Hao R, Lin CY, Williams C and Gustafsson JA (2015) Estrogen receptor signaling during vertebrate development. Biochim Biophys Acta 1849, 142-151   DOI
7 Lieberman S (1996) Are the differences between estradiol and other estrogens, naturally occurring or synthetic, merely semantical? J Clin Endocrinol Metab 81, 850-851   DOI
8 Gruber CJ, Tschugguel W, Schneeberger C and Huber JC (2002) Production and actions of estrogens. N Engl J Med 346, 340-352   DOI
9 Yasar P, Ayaz G, User SD, Gupur G and Muyan M (2017) Molecular mechanism of estrogen-estrogen receptor signaling. Reprod Med Biol 16, 4-20   DOI
10 Jeong W, Bae H, Lim W, Bazer FW and Song G (2017) RAS-related protein 1: an estrogen-responsive gene involved in development and molting-mediated regeneration of the female reproductive tract in chickens. Animal, 1-8
11 Castoria G, Migliaccio A, Di Domenico M et al (2004) Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol 24, 7643-7653   DOI
12 Bos JL, Rehmann H and Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877   DOI
13 Cherfils J and Zeghouf M (2013) Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 93, 269-309   DOI
14 McCormick F (1998) Going for the GAP. Curr Biol 8, R673-674
15 Avruch J, Khokhlatchev A, Kyriakis JM et al (2001) Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 56, 127-155   DOI
16 Falchook GS, Lewis KD, Infante JR et al (2012) Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 13, 782-789   DOI
17 Deroo BJ and Korach KS (2006) Estrogen receptors and human disease. J Clin Invest 116, 561-570   DOI
18 Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS and Smithies O (1993) Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 90, 11162-11166   DOI
19 Weihua Z, Saji S, Makinen S et al (2000) Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Proc Natl Acad Sci U S A 97, 5936-5941   DOI
20 Couse JF and Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20, 358-417   DOI
21 Choi Y, Kim HR, Lim EJ et al (2016) Integrative analyses of uterine Transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PLoS One 11, e0157696   DOI
22 Bingel AS (1974) Timing of LH release and ovulation in 4-and 5-day cyclic mice. J Reprod Fertil 40, 315-320   DOI
23 Hillier SG, Whitelaw PF and Smyth CD (1994) Follicular oestrogen synthesis: the 'two-cell, two-gonadotrophin' model revisited. Mol Cell Endocrinol 100, 51-54   DOI
24 Lee Y, Kim KH, Yoon H et al (2016) RASD1 knockdown results in failure of oocyte maturation. Cell Physiol Biochem 40, 1289-1302   DOI
25 Wang L, Mitsui T, Ishida M, Izawa M and Arita J (2017) Rasd1 is an estrogen-responsive immediate early gene and modulates expression of late genes in rat anterior pituitary cells. Endocr J 64, 1063-1071   DOI
26 Foster JS, Henley DC, Ahamed S and Wimalasena J (2001) Estrogens and cell-cycle regulation in breast cancer. Trends Endocrinol Metab 12, 320-327   DOI
27 Falk JD, Vargiu P, Foye PE et al (1999) Rhes: A striatal-specific Ras homolog related to Dexras1. J Neurosci Res 57, 782-788   DOI
28 Kim HR, Cho KS, Kim E et al (2017) Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus. Mol Cell Endocrinol 446, 32-39   DOI
29 Kemppainen RJ and Behrend EN (1998) Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem 273, 3129-3131   DOI
30 Graham TE, Key TA, Kilpatrick K and Dorin RI (2001) Dexras1/AGS-1, a steroid hormone-induced guanosine triphosphate-binding protein, inhibits 3',5'-cyclic adenosine monophosphate-stimulated secretion in AtT-20 corticotroph cells. Endocrinology 142, 2631-2640   DOI
31 Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME and Karas RH (2004) Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci U S A 101, 17126-17131   DOI
32 Cheskis BJ, Greger JG, Nagpal S and Freedman LP (2007) Signaling by estrogens. J Cell Physiol 213, 610-617   DOI
33 McCormick F (1995) Ras-related proteins in signal transduction and growth control. Mol Reprod Dev 42, 500-506   DOI
34 Graham TE, Qiao Z and Dorin RI (2004) Dexras1 inhibits adenylyl cyclase. Biochem Biophys Res Commun 316, 307-312   DOI
35 Nguyen CH and Watts VJ (2005) Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1. Biochem Biophys Res Commun 332, 913-920   DOI
36 Fang M, Jaffrey SR, Sawa A, Ye K, Luo X and Snyder SH (2000) Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28, 183-193   DOI
37 Shen A, Chen M, Niu S et al (2008) Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. J Chem Neuroanat 35, 85-93   DOI
38 Vaidyanathan G, Cismowski MJ, Wang G, Vincent TS, Brown KD and Lanier SM (2004) The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene 23, 5858-5863   DOI
39 Kato S, Endoh H, Masuhiro Y et al (1995) Activation of the estrogen receptor through phosphorylation by mitogenactivated protein kinase. Science 270, 1491-1494   DOI
40 Wennerberg K, Rossman KL and Der CJ (2005) The Ras superfamily at a glance. J Cell Sci 118, 843-846   DOI
41 Malumbres M and Barbacid M (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3, 459-465   DOI
42 Simanshu DK, Nissley DV and McCormick F (2017) RAS Proteins and Their Regulators in Human Disease. Cell 170, 17-33   DOI
43 Razandi M, Oh P, Pedram A, Schnitzer J and Levin ER (2002) ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol 16, 100-115   DOI
44 Kumar P, Wu Q, Chambliss KL et al (2007) Direct interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha. Mol Endocrinol 21, 1370-1380   DOI
45 Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R and Santen RJ (2004) The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc Natl Acad Sci U S A 101, 2076-2081   DOI
46 Song RX, McPherson RA, Adam L et al (2002) Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol Endocrinol 16, 116-127
47 Cabodi S, Moro L, Baj G et al (2004) p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci 117, 1603-1611   DOI
48 Nelson LR and Bulun SE (2001) Estrogen production and action. J Am Acad Dermatol 45, S116-124   DOI
49 Pierce JG and Parsons TF (1981) Glycoprotein hormones: structure and function. Annu Rev Biochem 50, 465-495   DOI
50 Anderson DC (1974) Sex-hormone-binding globulin. Clin Endocrinol (Oxf) 3, 69-96   DOI