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http://dx.doi.org/10.5483/BMBRep.2018.51.4.005

Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway  

Wang, Yuli (Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University)
Chen, Xichen (Analysis Center, Nanjing Medical University)
Yin, Ying (Nanjing Stomatological Hospital, Medical School of Nanjing University)
Li, Song (Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University)
Publication Information
BMB Reports / v.51, no.4, 2018 , pp. 194-199 More about this Journal
Abstract
Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.
Keywords
Angiogenesis; ERK1/2 MAPK signaling pathway; Human adipose-derived stem cells; Human amnion-derived mesenchymal stem cells; Osteogenesis;
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