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http://dx.doi.org/10.5483/BMBRep.2018.51.1.184

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter  

Yang, Xueliang (Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University)
Han, Ming (Peking University Ditan Teaching Hospital)
Liu, Shunai (Beijing Key Laboratory of Emerging Infectious Diseases)
Yuan, Xiaoxue (Beijing Key Laboratory of Emerging Infectious Diseases)
Liu, Xiaojing (Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University)
Feng, Shenghu (Peking University Ditan Teaching Hospital)
Zhou, Li (Peking University Ditan Teaching Hospital)
Li, Yaru (Beijing Key Laboratory of Emerging Infectious Diseases)
Lu, Hongping (Beijing Key Laboratory of Emerging Infectious Diseases)
Cheng, Jun (Peking University Ditan Teaching Hospital)
Lin, Shumei (Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University)
Publication Information
BMB Reports / v.51, no.1, 2018 , pp. 33-38 More about this Journal
Abstract
Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the -139- to +359-bp region). Moreover, we observed that HCBP6 interacted with $C/EBP{\beta}-binding$ site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the $C/EBP{\beta}-binding$ site in the SREBP1c promoter.
Keywords
$C/EBP{\beta}$; HCBP6; SREBP1c; Transcription factor; Triglyceride homeostasis;
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