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http://dx.doi.org/10.5483/BMBRep.2017.50.3.191

Neuropeptide Y-based recombinant peptides ameliorate bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization  

Park, Min Hee (Stem Cell Neuroplasticity Research Group, Kyungpook National University)
Kim, Namoh (Stem Cell Neuroplasticity Research Group, Kyungpook National University)
Jin, Hee Kyung (Stem Cell Neuroplasticity Research Group, Kyungpook National University)
Bae, Jae-sung (Stem Cell Neuroplasticity Research Group, Kyungpook National University)
Publication Information
BMB Reports / v.50, no.3, 2017 , pp. 138-143 More about this Journal
Abstract
Ovariectomy-induced bone loss is related to an increased deposition of osteoclasts on bone surfaces. We reported that the 36-amino-acid-long neuropeptide Y (NPY) could mobilize hematopoietic stem/progenitor cells (HSPCs) from the bone marrow to the peripheral blood by regulating HSPC maintenance factors and that mobilization of HSPCs ameliorated low bone density in an ovariectomy-induced osteoporosis mouse model by reducing the number of osteoclasts. Here, we demonstrated that new NPY peptides, recombined from the cleavage of the full-length NPY, showed better functionality for HSPC mobilization than the full-length peptide. These recombinant peptides mediated HSPC mobilization with greater efficiency by decreasing HSPC maintenance factors. Furthermore, treatment with these peptides reduced the number of osteoclasts and relieved ovariectomy-induced bone loss in mice more effectively than treatment with full-length NPY. Therefore, these results suggest that peptides recombined from full-length NPY can be used to treat osteoporosis.
Keywords
Bone loss; Hematopoietic stem/progenitor cell; Mobilization; Neuropeptide Y-based recombinant peptides; Osteoclasts;
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