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http://dx.doi.org/10.5483/BMBRep.2017.50.1.193

Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner  

Song, Mi Hye (Department of Pathology, Hallym University College of Medicine)
Nair, Varun Sasidharan (Department of Pathology, Hallym University College of Medicine)
Oh, Kwon Ik (Department of Pathology, Hallym University College of Medicine)
Publication Information
BMB Reports / v.50, no.1, 2017 , pp. 49-54 More about this Journal
Abstract
Previously, we reported that vitamin C facilitates the CpG demethylation of Foxp3 enhancer in $CD4^+Foxp3^+$ regulatory T cells (Tregs) by enhancing the activity of a DNA demethylase ten-eleven-translocation (Tet). However, it is not clear whether vitamin C affects other helper T cell lineages like T helper type 17 (Th17) cells which are related with Tregs. Here, we show that the expression of interleukin-17A (IL17) increases with the treatment of vitamin C but not with other antioxidants. Interestingly, the upregulation of IL17 was not accompanied by DNA demethylation in Il17 promoter and was independent of Tet enzymes. Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in the regulatory elements of the Il17 locus, and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2). These results suggest that vitamin C can affect the expression of IL17 by modulating the histone demethylase activity.
Keywords
H3K9me3; Histone modification; IL17; Jmjd2; Vitamin C;
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Times Cited By KSCI : 4  (Citation Analysis)
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