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http://dx.doi.org/10.5483/BMBRep.2017.50.10.043

The anti-microbial peptide SR-0379 stimulates human endothelial progenitor cell-mediated repair of peripheral artery diseases  

Lee, Tae Wook (Department of Physiology, School of Medicine, Pusan National University)
Heo, Soon Chul (Department of Physiology, School of Medicine, Pusan National University)
Kwon, Yang Woo (Department of Physiology, School of Medicine, Pusan National University)
Park, Gyu Tae (Department of Physiology, School of Medicine, Pusan National University)
Yoon, Jung Won (Department of Physiology, School of Medicine, Pusan National University)
Kim, Seung-Chul (Department of Obstetrics and Gynecology, School of Medicine, Pusan National University)
Jang, Il Ho (Department of Oral Biochemistry and Molecular Biology, Pusan National University School of Dentistry)
Kim, Jae Ho (Department of Physiology, School of Medicine, Pusan National University)
Publication Information
BMB Reports / v.50, no.10, 2017 , pp. 504-509 More about this Journal
Abstract
Ischemia is a serious disease, characterized by an inadequate blood supply to an organ or part of the body. In the present study, we evaluated the effects of the anti-microbial peptide SR-0379 on the stem cell-mediated therapy of ischemic diseases. The migratory and tube-forming abilities of human endothelial progenitor cells (EPCs) were enhanced by treatment with SR-0379 in vitro. Intramuscular administration of SR-0379 into a murine ischemic hindlimb significantly enhanced blood perfusion, decreased tissue necrosis, and increased the number of blood vessels in the ischemic muscle. Moreover, co-administration of SR-0379 with EPCs stimulated blood perfusion in an ischemic hindlimb more than intramuscular injection with either SR-0379 or EPCs alone. This enhanced blood perfusion was accompanied by a significant increase in the number of CD31- and ${\alpha}$-SMA-positive blood vessels in ischemic hindlimb. These results suggest that SR-0379 is a potential drug candidate for potentiating EPC-mediated therapy of ischemic diseases.
Keywords
Angiogenesis; Endothelial progenitor cells; Hindlimb ischemia; Peripheral artery diseases; SR-0379;
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