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http://dx.doi.org/10.5483/BMBRep.2016.49.9.074

Analysis of extended haplotype in Korean cattle (Hanwoo) population  

Lim, Dajeong (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA)
Choi, Bong Hwan (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA)
Cho, Yong Min (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA)
Chai, Han Ha (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA)
Jang, Gul Won (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA)
Gondro, Cedric (School of Environmental and Rural Science, University of New England)
Jeoung, Yeoung Ho (Hanwoo Department, Korea Animal Improvement Association)
Lee, Seung Hwan (Division of Animal and Dairy Science, Chung Nam National University)
Publication Information
BMB Reports / v.49, no.9, 2016 , pp. 514-519 More about this Journal
Abstract
Korean cattle (Hanwoo) are categorized into three breeds based on color: brown, brindle, and black. Among these breeds, brown Hanwoo has been subjected to intensive selection to improve meat traits. To identify genetic traces driven by recent selection in brown Hanwoo, we scanned the genomes of brown and brindle Hanwoo using a bovine SNP chip. We identified 17 candidate selection signatures in brown Hanwoo and sequenced four candidate regions from 10 individuals each of brown and brindle Hanwoo. In particular, non-synonymous SNPs in the ADSL gene (K88M, L189H, and R302Q) might have had mutational effects on protein structure as a result of altering the purine pathway during nucleotide breakdown. The ADSL gene was previously reported to affect meat quality and yield in livestock. Meat quality and yield are main breeding goals for brown Hanwoo, and our results support a potential causal influence of non-synonymous SNPs in the ADSL gene.
Keywords
ADSL; Brindle Hanwoo; Extendend haplotype; Hanwoo;
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