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http://dx.doi.org/10.5483/BMBRep.2016.49.7.070

Forensic DNA methylation profiling from evidence material for investigative leads  

Lee, Hwan Young (Department of Forensic Medicine, Yonsei University College of Medicine)
Lee, Soong Deok (Department of Forensic Medicine, Seoul National University College of Medicine)
Shin, Kyoung-Jin (Department of Forensic Medicine, Yonsei University College of Medicine)
Publication Information
BMB Reports / v.49, no.7, 2016 , pp. 359-369 More about this Journal
Abstract
DNA methylation is emerging as an attractive marker providing investigative leads to solve crimes in forensic genetics. The identification of body fluids that utilizes tissue-specific DNA methylation can contribute to solving crimes by predicting activity related to the evidence material. The age estimation based on DNA methylation is expected to reduce the number of potential suspects, when the DNA profile from the evidence does not match with any known person, including those stored in the forensic database. Moreover, the variation in DNA implicates environmental exposure, such as cigarette smoking and alcohol consumption, thereby suggesting the possibility to be used as a marker for predicting the lifestyle of potential suspect. In this review, we describe recent advances in our understanding of DNA methylation variations and the utility of DNA methylation as a forensic marker for advanced investigative leads from evidence materials.
Keywords
Age prediction; Body fluid identification; DNA methylation; Forensic genetics; Investigative lead;
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