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http://dx.doi.org/10.5483/BMBRep.2016.49.6.207

Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules  

Park, Yoon-Kyung (Department of Life Sciences, Korea University)
Jung, Sundo (Department of Life Sciences, Korea University)
Park, Se-Ho (Department of Life Sciences, Korea University)
Publication Information
BMB Reports / v.49, no.6, 2016 , pp. 331-336 More about this Journal
Abstract
In murine collagen-induced arthritis (CIA), self-reactive T cells can recognize peptide antigens derived from type-II collagen (CII). Activation of T cells is an important mediator of autoimmune diseases. Thus, T cells have become a focal point of study to treat autoimmune diseases. In this study, we evaluated the efficacy of recombinant MHC class II molecules in the regulation of antigen-specific T cells by using a self peptide derived from CII (CII260-274; IAGFKGEQGPKGEPG) linked to mouseI-Aq in a murine CIA model. We found that recombinant I-Aq/CII260-274 molecules could be recognized by CII-specific T cells and inhibit the same T cells in vitro. Furthermore, the development of CIA in mice was successfully prevented by in vivo injection of recombinant I-Aq/CII260-274 molecules. Thus, treatment with recombinant soluble MHC class II molecules in complex with an immunodominant self-peptide might offer a potential therapeutic for chronic inflammation in autoimmune disease such as rheumatoid arthritis.
Keywords
Collagen-induced arthritis; Immunotherapy; Rheumatoid arthriti; Recombinant MHC II; Type-II collagen;
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