Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade |
Kim, Geun-Young
(Division of Cardiovascular and Rare Disease, Center for Biomedical Sciences, Korea National Institute of Health)
Park, Soon Yong (Department of Biological Science, Dong-A University) Jo, Ara (Department of Biological Science, Dong-A University) Kim, Mira (Department of Biological Science, Dong-A University) Leem, Sun-Hee (Department of Biological Science, Dong-A University) Jun, Woo-Jin (Department of Food and Nutrition, Chonnam National University) Shim, Sang In (Department of Agronomy, Gyeongsang National University) Lee, Sang Chul (Research Center for Integrative Cellulomics, Korea Research Institute of Bioscience and Biotechnology) Chung, Jin Woong (Department of Biological Science, Dong-A University) |
1 | Brown JK, Hollenberg MD and Jones CA (2006) Tryptase activates phosphatidylinositol 3-kinases proteolytically independently from proteinase-activated receptor-2 in cultured dog airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 290, L259-269 DOI |
2 | Liao AC, Kuo CC, Huang YC et al (2014) Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP2. Mol Med Rep 10, 1531-1536 DOI |
3 | Li J, Jiang K, Qiu X et al (2014) Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer. BMB Rep 47, 33-38 DOI |
4 | Altomare DA and Testa JR (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24, 7455-7464 DOI |
5 | Zhao B and Li X (2014) Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncol Rep 31, 2769-2775 DOI |
6 | Choi EM, Kwak SJ, Kim YM et al (2005) COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp Mol Med 37, 199-203 DOI |
7 | Sagar S, Esau L, Holtermann K et al (2013) Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts. BMC Complement Altern Med 13, 344 DOI |
8 | Lee HW, Jang KS, Choi HJ, Jo A, Cheong JH and Chun KH (2014) Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy. BMB Rep 47, 697-702 DOI |
9 | Watanabe T, Nakamura S, Ono T et al (2014) Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun 451, 93-100 DOI |
10 | Zhang SX, Zhu C, Ba Y et al (2012) Gekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factor. J Biol Chem 287, 13206-13215 DOI |
11 | Jeong AJ, Chung CN, Kim HJ et al (2012) Gecko Proteins Exert Anti-Tumor Effect against Cervical Cancer Cells Via PI3-Kinase/Akt Pathway. Korean J Physiol Pharmacol 16, 361-365 DOI |
12 | Botteman MF, Pashos CL, Redaelli A, Laskin B and Hauser R (2003) The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics 21, 1315-1330 DOI |
13 | Kaplan AL, Litwin MS and Chamie K (2014) The future of bladder cancer care in the USA. Nat Rev Urol 11, 59-62 DOI |
14 | Stenzl A, Cowan NC, De Santis M et al (2009) The updated EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol 55, 815-825 DOI |
15 | Herr HW and Morales A (2008) History of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story. J Urol 179, 53-56 DOI |
16 | Addeo R, Caraglia M, Bellini S et al (2010) Randomized phase III trial on gemcitabine versus mytomicin in recurrent superficial bladder cancer: evaluation of efficacy and tolerance. J Clin Oncol 28, 543-548 DOI |
17 | Connett GJ and Lee BW (1994) Treating childhood asthma in Singapore: when West meets East. BMJ 308, 1282-1284 DOI |
18 | Liu F, Wang JG, Wang SY, Li Y, Wu YP and Xi SM (2008) Antitumor effect and mechanism of Gecko on human esophageal carcinoma cell lines in vitro and xenografted sarcoma 180 in Kunming mice. World J Gastroenterol 14, 3990-3996 DOI |
19 | Song Y, Wang JG, Li RF et al (2012) Gecko crude peptides induce apoptosis in human liver carcinoma cells in vitro and exert antitumor activity in a mouse ascites H22 xenograft model. J Biomed Biotechnol 2012, 743573 |
20 | Wang YX, Gu XX, Geng D et al (2014) Differentiation of bel-7402 human hepatocarcinoma cells induced by aqueous extracts of fresh gecko (AG) and its anti-tumor activity in vivo. J Ethnopharmacol 155, 1583-1588 DOI |
21 | Wang X, Wang S and Wang J (2010) [Effect of gecko alcohol extract on human esophageal squamous carcinoma cell line EC9706 and anti-tumor activity in vivo]. Zhongguo Zhong Yao Za Zhi 35, 2175-2179 |
22 | Zhou H, Li XM, Meinkoth J and Pittman RN (2000) Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 151, 483-494 DOI |
23 | Jeong SJ, Dasgupta A, Jung KJ et al (2008) PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 370, 264-272 DOI |
24 | Riedl SJ and Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5, 897-907 DOI |
25 | Song JY, Wang XL, Wang JG et al (2011) [Inhibitory effects of Gecko alcohol extract on human esophageal squamous carcinoma cell line EC-109 proliferation and associated mechanism]. Zhong Yao Cai 34, 1020-1023 |
26 | Ma Y, Zhang B, Qian R, Lu C, Zhao F and Yin L (2006) Tryptase activates PKB in inflammatory reaction in ECV304 cells. Biochim Biophys Acta 1763, 313-321 DOI |
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