Browse > Article
http://dx.doi.org/10.5483/BMBRep.2015.48.9.017

Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo  

Ku, Sae-Kwang (Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University)
Bae, Jong-Sup (College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Publication Information
BMB Reports / v.48, no.9, 2015 , pp. 519-524 More about this Journal
Abstract
Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS) and activation of nuclear factor (NF)-κB. Remarkably, all of the above mentioned vascular inflammatory effects of HG were attenuated by pretreatment with baicalin, baicalein, and wogonin. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications, therefore, our results suggest that baicalin, baicalein, and wogonin may have significant therapeutic benefits against diabetic complications and atherosclerosis. [BMB Reports 2015; 48(9): 519-524]
Keywords
Baicalein; Baicalin; Diabetes mellitus; Wogonin; High glucose;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Roglic G, Unwin N, Bennett PH et al (2005) The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care 28, 2130-2135   DOI
2 Rubino F and Gagner M (2002) Potential of surgery for curing type 2 diabetes mellitus. Ann Surg 236, 554-559   DOI
3 Li GQ, Kam A, Wong KH et al (2012) Herbal medicines for the management of diabetes. Adv Exp Med Biol 771, 396-413
4 Day C (1998) Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr 80, 5-6   DOI
5 Kubo M, Asano T, Shiomoto H and Matsuda H (1994) Studies on rehmanniae radix. I. Effect of 50% ethanolic extract from steamed and dried rehmanniae radix on hemorheology in arthritic and thrombosic rats. Biol Pharm Bull 17, 1282-1286   DOI
6 Kubo M, Matsuda H, Tanaka M et al (1984) Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix. Chem Pharm Bull (Tokyo) 32, 2724-2729   DOI
7 Uemura S, Matsushita H, Li W et al (2001) Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res 88, 1291-1298   DOI
8 Morigi M, Angioletti S, Imberti B et al (1998) Leukocyteendothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest 101, 1905-1915   DOI
9 Lopes-Virella MF and Virella G (1992) Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes 41 Suppl 2, 86-91   DOI
10 Bae JS (2012) Role of high mobility group box 1 in inflammatory disease: Focus on sepsis. Arch Pharm Res 35, 1511-1523   DOI
11 Kado S, Wakatsuki T, Yamamoto M and Nagata N (2001) Expression of intercellular adhesion molecule-1 induced by high glucose concentrations in human aortic endothelial cells. Life Sci 68, 727-737   DOI
12 Dunlop M (2000) Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl 77, S3-12   DOI
13 Hansson GK and Libby P (2006) The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6, 508-519   DOI
14 Boisvert WA (2004) Modulation of atherogenesis by chemokines. Trends Cardiovasc Med 14, 161-165   DOI
15 Inoguchi T, Li P, Umeda F et al (2000) High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49, 1939-1945   DOI
16 Han HJ, Lee YJ, Park SH, Lee JH and Taub M (2005) High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells. Am J Physiol Renal Physiol 288, F988-996   DOI
17 Rimbach G, Valacchi G, Canali R and Virgili F (2000) Macrophages stimulated with IFN-gamma activate NFkappa B and induce MCP-1 gene expression in primary human endothelial cells. Mol Cell Biol Res Commun 3, 238-242   DOI
18 Chen YC, Shen SC, Chen LG, Lee TJ and Yang LL (2001) Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 61, 1417-1427   DOI
19 Chiu JH, Lay IS, Su MY et al (2002) Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. Planta Med 68, 1036-1039   DOI
20 Laakso M (1999) Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 48, 937-942   DOI
21 Tooke JE (1995) Microvascular function in human diabetes. A physiological perspective. Diabetes 44, 721-726   DOI
22 Kannel WB and McGee DL (1979) Diabetes and cardiovascular disease. The Framingham study. JAMA 241, 2035-2038   DOI
23 Nannipieri M, Rizzo L, Rapuano A, Pilo A, Penno G and Navalesi R (1995) Increased transcapillary escape rate of albumin in microalbuminuric type II diabetic patients. Diabetes Care 18, 1-9   DOI
24 Wardle EN (1994) Vascular permeability in diabetics and implications for therapy. Diabetes Res Clin Pract 23, 135-139   DOI
25 Gerrity RG (1981) The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103, 181-190
26 Esposito C, Fasoli G, Plati AR et al (2001) Long-term exposure to high glucose up-regulates VCAM-induced endo- thelial cell adhesiveness to PBMC. Kidney Int 59, 1842-1849   DOI
27 Hamuro M, Polan J, Natarajan M and Mohan S (2002) High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration. Atherosclerosis 162, 277-287   DOI
28 Whiting DR, Guariguata L, Weil C and Shaw J (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94, 311-321   DOI
29 Grundy SM, Benjamin IJ, Burke GL et al (1999) Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100, 1134-1146   DOI
30 Thomas JE and Foody JM (2007) The pathophysiology of cardiovascular disease in diabetes mellitus and the future of therapy. J Cardiometab Syndr 2, 108-113   DOI