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http://dx.doi.org/10.5483/BMBRep.2015.48.6.202

Anti-septic activity of α-cubebenoate isolated from Schisandra chinensis  

Kook, Minsoo (Department of Biological Sciences, Sungkyunkwan University)
Lee, Sung Kyun (Department of Biological Sciences, Sungkyunkwan University)
Kim, Sang Doo (Department of Biological Sciences, Sungkyunkwan University)
Lee, Ha Young (Department of Biological Sciences, Sungkyunkwan University)
Hwang, Jae Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Choi, Young Whan (Department of Horticultural Bioscience, College of Natural Resources and Life Science, Pusan National University)
Bae, Yoe-Sik (Department of Biological Sciences, Sungkyunkwan University)
Publication Information
BMB Reports / v.48, no.6, 2015 , pp. 336-341 More about this Journal
Abstract
Sepsis is a life-threatening, infectious, systemic inflammatory disease. In this study, we investigated the therapeutic effect of α-cubebenoate, a novel compound isolated from Schisandra chinensis against polymicrobial sepsis in a cecal ligation and puncture (CLP) experimental model. Administration of α-cubebenoate strongly enhanced survival in the CLP model. α-cubebenoate administration also markedly blocked CLP-induced lung inflammation and increased bactericidal activity by enhancing phagocytic activity and hydrogen peroxide generation in mouse bone marrow-derived macrophages and neutrophils. Expression of two important inflammatory cytokines, IL-1 and IL-6, was strongly increased in the CLP model, and this was dramatically blocked by α-cubebenoate. Lymphocyte apoptosis and caspase-3 activation, which are associated with immune paralysis during sepsis, were markedly attenuated by α-cubebenoate. Taken together, our findings indicate that α-cubebenoate, a natural compound isolated from Schisandra chinensis, is a powerful potential anti-septic agent. [BMB Reports 2015; 48(6): 336-341]
Keywords
α-Cubebenoate; Apoptosis; Bactericidal activity; Inflammation; Sepsis;
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1 Caamaño J and Hunter CA (2002) NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15, 414-429   DOI
2 Andreakos E, Sacre SM, Smith C et al (2004) Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood 103, 2229-2237   DOI   ScienceOn
3 Kretz-Remy C, Mehlen P, Mirault ME and Arrigo AP (1996) Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression. J Cell Biol 133, 1083-1093   DOI   ScienceOn
4 Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S and Remick DG (2011) The pathogenesis of sepsis. Annu Rev Pathol 6, 19-48   DOI   ScienceOn
5 Wesche DE, Lomas-Neira JL, Perl M, Chung CS and Ayala A (2005) Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol 78, 325-337   DOI   ScienceOn
6 Oberholzer C, Oberholzer A, Clare-Salzler M and Moldawer LL (2001) Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 15, 879-892   DOI
7 ProCESS Investigators, Yealy DM, Kellum JA et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370, 1683-1693   DOI   ScienceOn
8 Chen DF, Zhang SX, Kozuka M et al (2002) Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. J Nat Prod 65, 1242-1245   DOI   ScienceOn
9 Kim SD, Kim YK, Lee HY et al (2010) The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection. J Immunol 185, 4302-4310   DOI
10 Yasukawa K, Ikeya Y, Mitsuhashi H et al (1992) Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol -13-acetate in two-stage carcinogenesis in mouse skin. Oncology 49, 68-71   DOI   ScienceOn
11 Kang S, Lee KP, Park SJ et al (2014) Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis. J Ethnopharmacol 153, 242-249   DOI   ScienceOn
12 Kim SD, Lee HY, Shim JW et al (2011) Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med 184, 243-251   DOI   ScienceOn
13 Simard JC, Simon MM, Tessier PA and Girard D (2011) Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis. J Immunol 186, 3622-3631   DOI
14 Angus DC and van der Poll T (2013) Severe sepsis and septic shock. N Engl J Med 369, 840-851   DOI   ScienceOn
15 Riedemann NC, Guo RF and Ward PA (2003) Novel strategies for the treatment of sepsis. Nat Med 9, 517-524   DOI   ScienceOn
16 Choi YW, Takamatsu S, Khan SI et al (2006) Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J Nat Prod 69, 356-359   DOI   ScienceOn
17 Coopersmith CM, Wunsch H, Fink MP et al (2012) A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med 40, 1072-1079   DOI   ScienceOn
18 Hotchkiss RS, Monneret G and Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13, 862-874   DOI   ScienceOn
19 Bosmann M and Ward PA (2013) The inflammatory response in sepsis. Trends Immunol 34, 129-136   DOI   ScienceOn
20 Kumar G, Kumar N, Taneja A et al (2011) Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 140, 1223-1231   DOI   ScienceOn
21 Wiersinga WJ, Leopold SJ, Cranendonk DR and van der Poll T (2014) Host innate immune responses to sepsis. Virulence 5, 36-44   DOI
22 Mayadas TN, Cullere X and Lowell CA (2014) The multifaceted functions of neutrophils. Annu Rev Pathol 9, 181-218   DOI   ScienceOn
23 Hotchkiss RS and Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348, 138-150   DOI   ScienceOn