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http://dx.doi.org/10.5483/BMBRep.2015.48.5.008

Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment  

Qin, Jun-fang (School of Medicine, Nankai University)
Jin, Feng-jiao (School of Medicine, Nankai University)
Li, Ning (School of Medicine, Nankai University)
Guan, Hai-tao (School of Medicine, Nankai University)
Lan, Lan (Tianjin Cancer Hospital, Tianjin Medical University)
Ni, Hong (School of Medicine, Nankai University)
Wang, Yue (School of Medicine, Nankai University)
Publication Information
BMB Reports / v.48, no.5, 2015 , pp. 295-300 More about this Journal
Abstract
Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor $ADR{\beta}2$ involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors. [BMB Reports 2015; 48(5): 295-300]
Keywords
Adrenergic receptor; Breast cancer; Epinephrine; Macrophage polarization; Stress;
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