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http://dx.doi.org/10.5483/BMBRep.2015.48.5.190

Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression  

Noh, Kyung Tae (Department of Infectious Diseases, Armed Forces Medical Research Institute)
Cho, Joon (Department of Neurosurgery, College of Medicine, Konkuk University)
Chun, Sung Hak (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University)
Jang, Jong-Hwa (Department of Dental Hygiene, Hanseo University)
Cha, Gil Sun (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University)
Jung, In Duk (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University)
Jang, Dong Deuk (Department of Infectious Diseases, Armed Forces Medical Research Institute)
Park, Yeong-Min (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University)
Publication Information
BMB Reports / v.48, no.5, 2015 , pp. 283-288 More about this Journal
Abstract
We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naive CD8+ T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288]
Keywords
Bone marrow-derived dendritic cells; CD8+ T cell; Glycogen synthase kinase 3; Resveratrol; Tryptophanyl-tRNA synthetase;
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Times Cited By KSCI : 2  (Citation Analysis)
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