N-acetyl cysteine inhibits H2O2-mediated reduction in the mineralization of MC3T3-E1 cells by down-regulating Nrf2/HO-1 pathway |
Lee, Daewoo
(Institute of Oral Biosciences and School of Dentistry)
Kook, Sung-Ho (Institute of Oral Biosciences and School of DentistryDepartment of Bioactive Material Sciences and Institute of Molecular Biology and Genetics, Chonbuk National University) Ji, Hyeok (Institute of Oral Biosciences and School of Dentistry) Lee, Seung-Ah (Department of Nursing, Chonnam Techno College) Choi, Ki-Choon (Grassland and Forage Division, National Institute of Animal Science, RDA) Lee, Kyung-Yeol (Institute of Oral Biosciences and School of Dentistry) Lee, Jeong-Chae (Institute of Oral Biosciences and School of DentistryDepartment of Bioactive Material Sciences and Institute of Molecular Biology and Genetics, Chonbuk National University) |
1 | Chen JS, Huang PH, Wang CH et al (2011) Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis 214, 301-309 DOI |
2 | Yu J, Zhu X, Qi X, Che J and Cao B (2013) Paeoniflorin protects human EA.hy926 endothelial cells against gamma- radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway. Toxicol Lett 218, 224-234 DOI |
3 | Hinoi E, Fujimori S, Wang L, Hojo H, Uno K and Yoneda Y (2006) Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation. J Biol Chem 281, 18015-18024 DOI |
4 | Lin TH, Tang CH, Hung SY et al (2010) Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. J Cell Physiol 222, 757-768 |
5 | Lee JH and Cho JY (2014) Proteomics approaches for the studies of bone metabolism. BMB Rep 47, 141-148 DOI |
6 | Neve A, Corrado A and Cantatore FP (2013) Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol 228, 1149-1153 DOI |
7 | Jun JH, Lee SH, Kwak HB et al (2008) N-acetyl cysteine stimulates osteoblastic differentiation of mouse calvarial cells. J Cell Biochem 103, 1246-1255 DOI |
8 | Kim KA, Kook SH, Song JH and Lee JC (2014) A phenolic acid phenethyl urea derivative protects against irradiation- induced osteoblast damage by modulating intracellular redox state. J Cell Biochem 115, 1877-1887 |
9 | Arai M, Shibata Y, Pugdee K, Abiko Y and Ogata Y (2007) Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life 59, 27-33 DOI |
10 | Ahanger AA, Prawez S, Leo MD et al (2010) Pro-healing potential of hemin: an inducer of heme oxygenase-1. Eur J Pharmacol 645, 165-170 DOI |
11 | Kook YA, Lee SK, Son DH et al (2009) Effects of substance P on osteoblastic differentiation and heme oxygenase-1 in human periodontal ligament cells. Cell Biol Int 33, 424-428 DOI |
12 | Kozakowska M, Szade K, Dulak J and Jozkowicz A (2013) Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs. Antioxid Redox Signal 20, 1827-1850 DOI |
13 | Kim GY, Park SY, Jo A et al (2015) Gecko proteins induce the apoptosis of bladder cancer 5637 cell by inhibiting Akt and activating intrinsic caspase cascade. BMB Rep 48, 531-536 DOI |
14 | Park SS, Kim KA, Lee SY, Lim SS, Jeon YM and Lee JC (2012) X-ray radiation at low doses stimulates differentiation and mineralization of mouse calvarial osteoblasts. BMB Rep 45, 571-576 DOI |
15 | Heo JS, Lee SY and Lee JC (2010) Wnt/β-catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts. Mol Cells 30, 449-454 DOI |
16 | Jeon YM, Kook SH, Rho SJ et al (2013) Fibroblast growth factor-7 facilitates osteogenic differentiation of embryonic stem cells through the activation of ERK/Runx2 signaling. Mol Cell Biochem 382, 37-45 DOI |
17 | Yu JY, Zheng ZH, Son YO, Shi X, Jang YO and Lee JC (2011) Mycotoxin zearalenone induces AIF- and ROSmediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages. Toxicol In Vitro 25, 1654-1663 DOI |
18 | Bai XC, Lu D, Bai J et al (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 314, 197-207 DOI |
19 | Kondo H, Yumoto K, Alwood JS et al (2010) Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse. J Appl Physiol (1985) 108, 152-161 DOI |
20 | Mody N, Parhami F, Sarafian TA and Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31, 509-519 DOI |
21 | Banfi G, Iorio EL and Corsi MM (2008) Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 46, 1550-1555 |
22 | Jia P, Xu YJ, Zhang ZL et al (2012) Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species. J Orthop Res 30, 1843-1852 DOI |
23 | Ueno T, Yamada M, Igarashi Y and Ogawa T (2011) N-acetyl cysteine protects osteoblastic function from oxidative stress. J Biomed Mater Res A 99, 523-531 DOI |
24 | Singh PK, Wise SY, Ducey EJ, Fatanmi OO, Elliott TB and Singh VK (2012) α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury. Radiat Res 177, 133-145 DOI |
25 | Zhang Q, Pi J, Woods CG and Andersen ME (2010) A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol 244, 84-97 DOI |
26 | Shin SM, Yang JH and Ki SH (2013) Role of the Nrf2-ARE pathway in liver diseases. Oxid Med Cell Longev 2013, 763257 DOI |
27 | Rana T, Schultz MA, Freeman ML and Biswas S (2012) Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL. Free Radic Biol Med 53, 2298-2307 DOI |
28 | Maines MD and Panahian N (2001) The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Adv Exp Med Biol 502, 249-272 DOI |
29 | Zwerina J, Tzima S, Hayer S et al (2005) Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB J 19, 2011-2013 DOI |
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