Browse > Article
http://dx.doi.org/10.5483/BMBRep.2014.47.9.146

TM4SF5-mediated protein-protein networks and tumorigenic roles  

Lee, Jung Weon (Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University)
Publication Information
BMB Reports / v.47, no.9, 2014 , pp. 483-487 More about this Journal
Abstract
Transmembrane 4 L six family member 5 (TM4SF5), as a membrane glycoprotein with 4 transmembrane domains, is similar to the tetraspanins in terms of membrane topology and plays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-protein complex consisting of diverse membrane proteins and/or receptors in addition to cytosolic signaling molecules to regulate their signaling activities during the pathological processes. TM4SF5 is shown to interact with integrins ${\alpha}2$, ${\alpha}5$, and ${\beta}1$, EGFR, IL6R, CD151, focal adhesion kinase (FAK), and c-Src. This review focuses on the significance of the interactions with regards to TM4SF5-positive tumorigenesis and metastasis.
Keywords
Cytokine receptors; EGFR; Fibrosis; Integrins; Metastasis; Tetraspanin; TM4SF5;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hemler, M. E. (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19, 397-422.   DOI   ScienceOn
2 Hemler, M. E. (2005) Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol. 6, 801-811.   DOI   ScienceOn
3 Yanez-Mo, M., Barreiro, O., Gordon-Alonso, M., Sala-Valdes, M. and Sanchez-Madrid, F. (2009) Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends. Cell Biol. 19, 434-446.   DOI   ScienceOn
4 Lee, S. A., Lee, S. Y., Cho, I. H., Oh, M. A., Kang, E. S., Kim, Y. B., Seo, W. D., Choi, S., Nam, J. O., Tamamori-Adachi, M., Kitajima, S., Ye, S. K., Kim, S., Hwang, Y. J., Kim, I. S., Park, K. H. and Lee, J. W. (2008) Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. J. Clin. Invest. 118, 1354-1366.   DOI   ScienceOn
5 Berditchevski, F. and Odintsova, E. (2007) Tetraspanins as regulators of protein trafficking. Traffic 8, 89-96.   DOI   ScienceOn
6 Charrin, S., le Naour, F., Silvie, O., Milhiet, P. E., Boucheix, C. and Rubinstein, E. (2009) Lateral organization of membrane proteins: tetraspanins spin their web. Biochem. J. 420, 133-154.   DOI   ScienceOn
7 Jung, O., Choi, S., Jang, S. B., Lee, S. A., Lim, S. T., Choi, Y. J., Kim, H. J., Kim, D. H., Kwak, T. K., Kim, H., Kang, M., Lee, M. S., Park, S. Y., Ryu, J., Jeong, D., Cheong, H. K., Park, K. H., Lee, B. J., Schlaepfer, D. D. and Lee, J. W. (2012) Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J. Cell Sci. 125, 5960-5973.   DOI   ScienceOn
8 Ghosh, A. K., Quaggin, S. E. and Vaughan, D. E. (2013) Molecular basis of organ fibrosis: potential therapeutic approaches. Exp. Biol. Med (Maywood). 238, 461-481.   DOI   ScienceOn
9 Sangiovanni, A., Del Ninno, E., Fasani, P., De Fazio, C., Ronchi, G., Romeo, R., Morabito, A., De Franchis, R. and Colombo, M. (2004) Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 126, 1005-1014.   DOI   ScienceOn
10 Severi, T., van Malenstein, H., Verslype, C. and van Pelt, J. F. (2010) Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta. Pharmacol. Sin. 31, 1409-1420.   DOI
11 Meindl-Beinker, N. M., Matsuzaki, K. and Dooley, S. (2012) TGF-beta signaling in onset and progression of hepatocellular carcinoma. Dig. Dis. 30, 514-523.   DOI   ScienceOn
12 Mantovani, A., Savino, B., Locati, M., Zammataro, L., Allavena, P. and Bonecchi, R. (2010) The chemokine system in cancer biology and therapy. Cytokine. Growth. Factor. Rev. 21, 27-39.   DOI   ScienceOn
13 Choi, S., Lee, S. A., Kwak, T. K., Kim, H. J., Lee, M. J., Ye, S. K., Kim, S. H., Kim, S. and Lee, J. W. (2009) Cooperation between integrin $\alpha{5}$ and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood 113, 1845-1855.   DOI   ScienceOn
14 Ryu, J., Kang, M., Lee, M. S., Kim, H. J., Nam, S. H., Song, H. E., Lee, D. and Lee, J. W. (2014) Cross-talk between the TM4SF5/FAK and the IL6/STAT3 pathways renders immune escape of human liver cancer cells. Mol. Cell Biol. 34, 2946-2960.   DOI   ScienceOn
15 Kang, M., Ryu, J., Lee, D., Lee, M. S., Kim, H. J., Nam, S. H., Song, H. E., Choi, J., Lee, G. H., Kim, T. Y., Lee, H., Kim, S. J., Ye, S. K., Kim, S. and Lee, J. W. (2014) Correlations between Transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities. PLoS ONE 9, e102817. doi: 10.1371/journal.pone.0102817.   DOI   ScienceOn
16 Lietha, D., Cai, X., Ceccarelli, D. F., Li, Y., Schaller, M. D. and Eck, M. J. (2007) Structural basis for the autoinhibition of focal adhesion kinase. Cell 129, 1177-1187.   DOI   ScienceOn
17 Lee, S. A., Kim, Y. M., Kwak, T. K., Kim, H. J., Kim, S., Kim, S. H., Park, K. H., Cho, M. and Lee, J. W. (2009) The extracellular loop 2 of TM4SF5 inhibits integrin $\alpha{2}$ on hepatocytes under collagen type I environment. Carcinogenesis 30, 1872-1879.   DOI   ScienceOn
18 Lee, S. A., Ryu, H. W., Kim, Y. M., Choi, S., Lee, M. J., Kwak, T. K., Kim, H. J., Cho, M., Park, K. H. and Lee, J. W. (2009) Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology 49, 1316-1325.   DOI   ScienceOn
19 Lee, M. S., Kim, H. P., Kim, T. Y. and Lee, J. W. (2012) Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition. Biochim. Biophys. Acta. 1823, 514-523.   DOI   ScienceOn
20 Lee, S. Y., Kim, Y. T., Lee, M. S., Kim, Y. B., Chung, E., Kim, S. and Lee, J. W. (2006) Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin $\alpha{2}$ are regulated by serum treatment. Exp. Cell Res. 312, 2983-2999.   DOI   ScienceOn
21 Kang, M., Choi, S., Jeong, S. J., Lee, S. A., Kwak, T. K., Kim, H., Jung, O., Lee, M. S., Ko, Y., Ryu, J., Choi, Y. J., Jeong, D., Lee, H. J., Ye, S. K., Kim, S. H. and Lee, J. W. (2012) Cross-talk between TGFb1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition. Biochem. J. 443, 691-700.   DOI   ScienceOn
22 Kang, M., Jeong, S. J., Park, S. Y., Lee, H. J., Kim, H. J., Park, K. H., Ye, S. K., Kim, S. H. and Lee, J. W. (2012) Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in $CCl_4$-treated mice. FEBS. J. 279, 625-635.   DOI   ScienceOn
23 Veenbergen, S. and van Spriel, A. B. (2011) Tetraspanins in the immune response against cancer. Immunol. Lett. 138, 129-136.   DOI   ScienceOn
24 Detchokul, S., Williams, E. D., Parker, M. W. and Frauman, A. G. (2013) Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies. Br. J. Pharmacol. doi: 10.1111/bph.12260.   DOI   ScienceOn
25 Lee, S. A., Park, K. H. and Lee, J. W. (2011) Modulation of signaling between TM4SF5 and integrins in tumor microenvironment. Front. Biosci. 16, 1752-1758.   DOI
26 Muller-Pillasch, F., Wallrapp, C., Lacher, U., Friess, H., Buchler, M., Adler, G. and Gress, T. M. (1998) Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. Gene 208, 25-30.   DOI   ScienceOn
27 Jung, O., Choi, Y. J., Kwak, T. K., Kang, M., Lee, M. S., Ryu, J., Kim, H. J. and Lee, J. W. (2013) The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation. Biochim. Biophys. Acta. 1833, 629-642.   DOI   ScienceOn
28 Choi, Y. J., Kim, H. H., Kim, J. G., Kim, H. J., Kang, M., Lee, M. S., Ryu, J., Song, H. E., Nam, S. H., Lee, D., Kim, K. W. and Lee, J. W. (2014) TM4SF5 suppression disturbs integrin $\alpha{5}$-related signaling and muscle development in zebrafish. Biochem. J. 462, 89-101.   DOI   ScienceOn