MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN |
Ye, Xingming
(State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University)
Bai, Wendong (Department of Immunology, Fourth Military Medical University) Zhu, Huayu (State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University) Zhang, Xiao (State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University) Chen, Ying (Fujian Provincial Cancer Hospital, the Teaching Hospital of Fujian Medical University) Wang, Lei (State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University) Yang, Angang (Department of Immunology, Fourth Military Medical University) Zhao, Jing (State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University) Jia, Lintao (State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular, Biology, Fourth Military Medical University) |
1 | Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. and Ullrich, A. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712. DOI ScienceOn |
2 | Andersson, J., Linderholm, B., Greim, G., Lind, B., Lindman, H., Tennvall, J., Tennvall-Nittby, L., Pettersson-Skold, D., Sverrisdottir, A., Soderberg, M., Klaar, S. and Bergh, J. (2002) A population-based study on the first forty-eight breast cancer patients receiving trastuzumab (Herceptin) on a named patient basis in Sweden. Acta. Oncol. 41, 276-281. DOI |
3 | Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A. and McGuire,W. L. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177-182. DOI ScienceOn |
4 | Owens, M. A., Horten, B. C. and Da Silva, M. M. (2004) HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin. Breast Cancer 5, 63-69. DOI ScienceOn |
5 | Ross, J. S, Fletcher, J. A, Bloom, K. J., Linette, G. P., Stec, J., Symmans, W. F., Pusztai, L. and Hortobagyi, G. N. (2004) Targeted therapy in breast cancer: The HER-2/neu gene and protein. Mol. Cell Proteomics 3, 379-398. DOI ScienceOn |
6 | Baselga, J., Tripathy, D., Mendelsohn, J., Baughman, S., Benz, C. C., Dantis, L., Sklarin, N. T., Seidman, A. D., Hudis, C. A., Moore, J., Rosen, P. P., Twaddell, T., Henderson, I. C. and Norton, L. (1996) Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J. Clin. Oncol. 14, 737-744. |
7 | Menard, S., Fortis, S., Castiglioni, F., Agresti, R. and Balsari, A. (2001) HER2 as a prognostic factor in breast cancer. Oncology 61(Suppl 2),67-72. DOI ScienceOn |
8 | Adams, B. D., Guttilla, I. K. and White, B. A. (2008) Involvement of microRNAs in breast cancer. Semin. Reprod. Med. 26, 522-536. DOI ScienceOn |
9 | Press, M. F., Bernstein, L., Thomas, P. A., Meisner, L. F., Zhou, J. Y., Ma, Y., Hung, G., Robinson, R. A., Harris, C., El-Naggar, A., Slamon, D. J., Philips, R. N., Ross, J. S.,Wolman, S. R. and Flow, K. J. (1997) HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas. J. Clin. Oncol. 15, 2894-2904. |
10 | Bartel, D. P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297. DOI ScienceOn |
11 | Felicetti, F., Errico, M. C., Bottero, L., Segnalini, P., Stoppacciaro, A., Biffoni, M., Felli,N., Matttia, G., Petrini, M.,Colombo, M. P., Peschle, C. and Care, A. (2008) The promyelocytic leukemia zinc finger microRNA-221/222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res. 68, 2745-2754. DOI ScienceOn |
12 | Ahmad, A., Aboukameel, A., Kong, D.,Wang, Z. W., Sethi, S., Chen, W., Sarkar, F. H. and Raz, A. (2011) Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells. Cancer Res. 71, 3400-3409. DOI |
13 | Zhang, C. Z., Kang, C. S., Pu, P. Y., Wang, G. X., Jia, Z. F., Zhang, A. L., Han, L. and Xu, P. (2009) Inhibitory effect of knocking down microRNA-221 and microRNA-222 on glioma cell growth in vitro and in vivo. Zhonghua Zhong Liu Za Zhi 31, 721-726. |
14 | Zhang, C. Z., Han, L., Zhang, A. L., Fu, Y. C., Yue, X., Wang, G. X., Jia, Z. F., Pu, P. Y., Zhang, Q. Y. and Kang, C. S. (2010) MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. BMC Cancer 10, 367. DOI ScienceOn |
15 | Thompson, C., MacDonald, G. and Mueller, C. R. (2011) Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex. Mol. Cancer 10, 62-79. DOI |
16 | Miller, T. W., Rexer, B. N., Garrett, J. T. and Arteaga, C. L. (2011) Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Research 13, 224. DOI ScienceOn |
17 | Hollander, M. C., Blumenthal, G. M. and Dennis, P. M. (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer 11, 289-301. DOI ScienceOn |
18 | Liu, Z. L., Wang, H., Liu, J. and Wang, Z. X. (2013) MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radio resistance in non-small cell lung cancer cells by targeting PTEN. Mol. Cell Biochem. 372(1-2), 35-45. DOI ScienceOn |
19 | O'Brien, N. A., Browne, B. C., Chow, L., Wang, Y., Ginther, C., Arboleda, J., Duffy, M. J., Crown, J., O'Donovan, N. and Slaman, D. J. (2010) Activated phosphoinositide 3-Kinase/AKT signaling confers resistance to trastuzumab but not lapatinib mol. Cancer Ther. 9, 1489-1502. DOI |
20 | Li, J., Zhang Y., Zhao, J., Kong, F. and Chen, Y. (2011) Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. Mol. Cell Biochem. 357(1-2), 31-38. DOI ScienceOn |
21 | Wu, Z., He, B., He, J. and Mao, X. (2013) Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer. Prostate 73, 596-604. DOI ScienceOn |
22 | Eccles, S. A. (2002) The role of c-erbB-2/HER2/neu in breast cancer progression and metastases. J. Mammary Gland Biol. Neoplasia 6, 393-406. |
23 | Esteva, F. J., Sahin, A. A., Critofanilli, M., Arun, B. and Hortobagyi, G. N. (2002) Molecular prognostic factors for breast cancer metastases and survival. Sem. Radiat. Oncol. 12, 319-328. DOI ScienceOn |
24 | Garofalo, M., Di, L. G., Romano, G., Nuovo, G., Suh, S. S., Ngankeu, A., Taccioli, C., Pichiorri,F., Alder, H., Secchiero, P., Gasparini, P., Gonelli, A., Costinean, S., Acunzo, M., Condorelli, G. and Croce, C. M. (2009) miR-221 & 222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16, 498-509. DOI ScienceOn |
25 | Rao, X., Di, L. G., Li, M., Feng, F., Declin, C., Hartman-Frey, C., Burow, M. E., lvan, M., Croce, C. M. and Nephew, K. P. (2011) MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene 30, 1082-1097. DOI ScienceOn |
26 | Johanna, C. B., Susan, M. D., Harold, J. B., Harris, L., Younger, J., Kuter, I., Bunnell, C., Rue, M., Gelman, R. and Winer, E. (2003) Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 97, 2972-2977. DOI ScienceOn |
27 | Cobleigh, M. A., Vogel, C. L., Tripathy, D., Robert, N. J., Scholl, S., Fehrenbacher, L., Wolter, J. M., Paton, V., Shak, S., Lieberman, G. and Slamon D. J. (1999) Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17, 2639-2648. |
28 | Galardi, S., Mercatelli, N., Giorda, E., Massalini, S., Frajese, G. V., Ciafre, S. A. and Frarace, M. G. (2007) miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J. Biol. Chem. 282, 23716-23724. DOI ScienceOn |