[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2014.47.1.069

Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer

Li, Jia (Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University)
Jiang, Kuo (Orthopedics Oncology Institute, Tangdu Hospital, Fourth Military Medical University)
Qiu, Xiuchun (Orthopedics Oncology Institute, Tangdu Hospital, Fourth Military Medical University)
Li, Meng (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University)
Hao, Qiang (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University)
Wei, Li (Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University)
Zhang, Wei (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University)
Chen, BiLiang (Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University)
Xin, Xiaoyan (Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University)

Publication Information

BMB Reports / v.47, no.1, 2014 , pp. 33-38 More about this Journal

Abstract

The chemokine receptor 4 (CXCR4) plays an important role in the growth, angiogenesis and metastasis of various cancers, including epithelial ovarian cancer (EOC). However, the correlation between CXCR4 and the clinical response of EOC patients to chemotherapy remains unknown. 124 EOC patients were recruited to assess the relationship between CXCR4 and the response to cisplatin-based chemotherapy. The results showed that patients with a higher CXCR4 expression had a significantly lower chemosensitivity, a poorer progression-free survival and a lower overall survival than those with lower CXCR4 expression. In addition, knockdown of CXCR4 by small interfering RNA suppressed cell proliferation and resulted in G1/S arrest, increased apoptosis and chemosensitivity in both cisplatin-sensitive A2780 cells and cisplatin-resistant cell A2780/cis in vitro. Our data suggest that CXCR4 is one of the key molecules in cisplatin-based chemotherapy for EOC patients and that CXCR4 inhibition is a potential strategy to address the chemoresistance of EOC.

Keywords

Chemoresistance; Cisplatin; CXCR4; Epithelial ovarian cancer; Prognosis;

Citations & Related Records

Reference

1	Siegel, R., Naishadham, D. and Jemal, A. (2012) Cancer statistics, 2012. CA 62, 10-29.
2	Sudo, T. (2012) Molecular-targeted therapies for ovarian cancer: prospects for the future. Int. J. Clin. Oncol. 17, 424-429. DOI ScienceOn
3	Sueblinvong, T., Ghebre, R., Iizuka, Y., Pambuccian, S. E., Isaksson Vogel, R., Skubitz, A. P. and Bazzaro, M. (2012) Establishment, characterization and downstream application of primary ovarian cancer cells derived from solid tumors. PLOS One 7, e50519. DOI
4	Teicher, B. A. and Fricker, S. P. (2010) CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin. Cancer Res. 16, 2927-2931. DOI
5	Ying, J., Xu, Q., Zhang, G., Liu, B. and Zhu, L. (2012) The expression of CXCL12 and CXCR4 in gastric cancer and their correlation to lymph node metastasis. Med. Oncol. 29, 1716-1722. DOI ScienceOn
6	Yang, S. X., Loo, W. T., Chow, L. W., Yang, X. H., Zhan, Y., Fan, L. J., Zhang, F., Chen, L., Wang, Q. L., Xiao, H. L., Wu, J. L., Bian, X. W. and Jiang, J. (2012) Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy. J. Transl. Med. 10 (Suppl 1), S3. DOI
7	Murakami, T., Kawada, K., Iwamoto, M., Akagami, M., Hida, K., Nakanishi, Y., Kanda, K., Kawada, M., Seno, H., Taketo, M. M. and Sakai, Y. (2013) The role of CXCR3 and CXCR4 in colorectal cancer metastasis. Int. J. Cancer 132, 276-287. DOI ScienceOn
8	Jung, M. J., Rho, J. K., Kim, Y. M., Jung, J. E., Jin, Y. B., Ko, Y. G., Lee, J. S., Lee, S. J., Lee, J. C. and Park, M. J. (2013) Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene 32, 209-221. DOI ScienceOn
9	Sekiya, R., Kajiyama, H., Sakai, K., Umezu, T., Mizuno, M., Shibata, K., Yamamoto, E., Fujiwara, S., Nagasaka, T. and Kikkawa, F. (2012) Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary. Hum. Pathol. 43, 904-910. DOI ScienceOn
10	Domanska, U. M., Timmer-Bosscha, H., Nagengast, W. B., Oude Munnink, T. H., Kruizinga, R. C., Ananias, H. J., Kliphuis, N. M., Huls, G., De Vries, E. G., de Jong, I. J. and Walenkamp, A. M. (2012) CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy. Neoplasia 14, 709-718. DOI
11	Yu, T., Wu, Y., Huang, Y., Yan, C., Liu, Y., Wang, Z., Wang, X., Wen, Y., Wang, C. and Li, L. (2012) RNAi targeting CXCR4 inhibits tumor growth through inducing cell cycle arrest and apoptosis. Mol. Ther 20, 398-407. DOI
12	Chen, G., Chen, S. M., Wang, X., Ding, X. F., Ding, J. and Meng, L. H. (2012) Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. J. Biol. Chem. 287, 12132-12141. DOI
13	Dubrovska, A., Elliott, J., Salamone, R. J., Telegeev, G. D., Stakhovsky, A. E., Schepotin, I. B., Yan, F., Wang, Y., Bouchez, L. C., Kularatne, S. A., Watson, J., Trussell, C., Reddy, V. A., Cho, C. Y. and Schultz, P. G. (2012) CXCR4 expression in prostate cancer progenitor cells. PLOS One 7, e31226. DOI
14	Zhou, Z., Chen, Z. W., Yang, X. H., Shen, L., Ai, X. H., Lu, S. and Luo, Q. Q. (2012) Establishment of a biomarker model for predicting bone metastasis in resected stage III non-small cell lung cancer. J. Exp. Clin. Canc. Res. 31, 34. DOI
15	Dubrovska, A., Hartung, A., Bouchez, L. C., Walker, J. R., Reddy, V. A., Cho, C. Y. and Schultz, P. G. (2012) CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Brit. J. Cancer 107, 43-52. DOI ScienceOn
16	Wang, J., Cai, J., Han, F., Yang, C., Tong, Q., Cao, T., Wu, L. and Wang, Z. (2011) Silencing of CXCR4 blocks progression of ovarian cancer and depresses canonical Wnt signaling pathway. Int. J. Gynecol. Cancer 21, 981-987. DOI ScienceOn
17	Guo, P., You, J. O., Yang, J., Moses, M. A. and Auguste, D. T. (2012) Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity. Biomaterials 33, 8104-8110. DOI ScienceOn
18	Wang, L., Huang, T., Chen, W., Gao, X., Zhou, T., Wu, Z. and Sun, Y. (2012) Silencing of CXCR4 by RNA interference inhibits cell growth and metastasis in human renal cancer cells. Oncol. Rep. 28, 2043-2048. DOI
19	Scala, S., Ottaiano, A., Ascierto, P. A., Cavalli, M., Simeone, E., Giuliano, P., Napolitano, M., Franco, R., Botti, G. and Castello, G. (2005) Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin. Cancer Res. 11, 1835-1841. DOI ScienceOn
20	Kim, M., Koh, Y. J., Kim, K. E., Koh, B. I., Nam, D. H., Alitalo, K., Kim, I. and Koh, G. Y. (2010) CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 70, 10411-10421. DOI ScienceOn
21	Kim, J., Yip, M. L., Shen, X., Li, H., Hsin, L. Y., Labarge, S., Heinrich, E. L., Lee, W., Lu, J. and Vaidehi, N. (2012) Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells. PLOS One 7, e31004. DOI

Reference

	Richard L. Sleightholm. (2017) Pharmacology & Therapeutics Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy /
25	Jun Yeon Park. (2015) Journal of Agricultural and Food Chemistry Protective Effects of Processed Ginseng and Its Active Ginsenosides on Cisplatin-Induced Nephrotoxicity:In Vitroandin VivoStudies / 63 (25) , 5964
1	Renata A. Tassi. (2017) Journal of Experimental & Clinical Cancer Research FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients / 36 (1)
1	Min Ho Lee. (2015) Biochemical and Biophysical Research Communications Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells / 464 (1) , 63
7	Hyun Sook Hwang. (2015) BMB Reports PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model / 48 (7) , 407
2	Xiu-guo Han. (2015) Cancer Letters CXCR1 knockdown improves the sensitivity of osteosarcoma to cisplatin / 369 (2) , 405
9	Aayushi Jain. (2017) Expert Review of Anticancer Therapy Molecular approaches to potentiate cisplatin responsiveness in carcinoma therapeutics / 17 (9) , 815
5	Cuiping Shen. (2015) Molecular Medicine Reports Inhibitory effect and mechanisms of microRNA-146b-5p on the proliferation and metastatic potential of Caski human cervical cancer cells / 11 (5) , 3955
	Jun Yeon Park. (2015) Evidence-Based Complementary and Alternative Medicine Protective Effect ofArtemisia asiaticaExtract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage / 2015 , 1
5	Kiwon Jung. (2016) Bioorganic & Medicinal Chemistry Letters Protective effect and mechanism of action of saponins isolated from the seeds of gac (Momordica cochinchinensis Spreng.) against cisplatin-induced damage in LLC-PK1 kidney cells / 26 (5) , 1466
23	Seulah Lee. (2015) Bioorganic & Medicinal Chemistry Letters Protective effect and mechanism of action of lupane triterpenes from Cornus walteri in cisplatin-induced nephrotoxicity / 25 (23) , 5613
2	Hyun Hee Lee. (2017) PLOS ONE Chemotherapy induces adaptive drug resistance and metastatic potentials via phenotypic CXCR4-expressing cell state transition in ovarian cancer / 12 (2) , e0171044
3	Xiao-Feng Li. (2015) Asian Pacific Journal of Cancer Prevention Effect of CXCR4 and CD133 Co-expression on the Prognosis of Patients with Stage II~III Colon Cancer / 16 (3) , 1073
2	Myoung-Sik Han. (2016) Journal of Ginseng Research Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells / 40 (2) , 135
	Jun Yeon Park. (2016) Evidence-Based Complementary and Alternative Medicine Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells / 2016 , 1
9	Geun-Young Kim. (2015) BMB Reports Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade / 48 (9) , 531
2	Songping Xie. (2017) Oncology Reports CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner / 37 (2) , 921
1	Li Li. (2017) Journal of Ovarian Research Bioinformatics analysis to screen the key prognostic genes in ovarian cancer / 10 (1)
	Hee Rae Kang. (2016) Journal of Functional Foods Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity / 20 , 358
11	Noriko Yamabe. (2016) Bulletin of the Korean Chemical Society Synthesis of Renoprotective Chalcone Analogues That Protect Against Cisplatin-induced Cytotoxicity in LLC-PK1 Cells / 37 (11) , 1882
11	(2017) International Journal of Molecular Sciences Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells / 18 (11) , 2363
10	(2018) Cancers Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase / 10 (10) , 358