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http://dx.doi.org/10.5483/BMBRep.2014.47.12.020

Stathmin 1 in normal and malignant hematopoiesis  

Machado-Neto, Joao Agostinho (Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciencia e Tecnologia do Sangue)
Saad, Sara Teresinha Olalla (Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciencia e Tecnologia do Sangue)
Traina, Fabiola (Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciencia e Tecnologia do Sangue)
Publication Information
BMB Reports / v.47, no.12, 2014 , pp. 660-665 More about this Journal
Abstract
Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. The scope of the present review is to survey the current knowledge and highlight future perspectives for Stathmin 1 in normal and malignant hematopoiesis, with regard to the expression, function and clinical implications of this protein.
Keywords
Hematopoiesis; Leukemia; OP18; Stathmin 1; STMN1;
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