Browse > Article
http://dx.doi.org/10.5483/BMBRep.2013.46.9.021

PIDD mediates and stabilizes the interaction between RAIDD and Caspase-2 for the PIDDosome assembly  

Jang, Tae-Ho (School of Biotechnology and Graduate School of Biochemistry at Yeungnam University)
Park, Hyun Ho (School of Biotechnology and Graduate School of Biochemistry at Yeungnam University)
Publication Information
BMB Reports / v.46, no.9, 2013 , pp. 471-476 More about this Journal
Abstract
The PIDDosome, which is an oligomeric signaling complex composed of PIDD, RAIDD and caspase-2, can induce proximity-based dimerization and activation of caspase-2. In the PIDDosome assembly, the adaptor protein RAIDD interacts with PIDD and caspase-2 via CARD:CARD and DD:DD, respectively. To analyze the PIDDosome assembly, we purified all of the DD superfamily members and performed biochemical analyses. The results revealed that caspase-2 CARD is an insoluble protein that can be solubilized by its binding partner, RAIDD CARD, but not by full-length RAIDD; this indicates that full-length RAIDD in closed states cannot interact with caspase-2 CARD. Moreover, we found that caspase-2 CARD can be solubilized and interact with full-length RAIDD in the presence of PIDD DD, indicating that PIDD DD initially binds to RAIDD, after which caspase-2 can be recruited to RAIDD via a CARD:CARD interaction. Our study will be useful in determining the order of assembly of the PIDDosome.
Keywords
Apoptosis; CARD; Caspase-2; DD; PIDD; PIDDosome; RAIDD;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Navratil, J. S. and Ahearn, J. M. (2001) Apoptosis, clearance mechanisms, and the development of systemic lupus erythematosus. Curr. Rheumatol. Rep. 3, 191-198.   DOI   ScienceOn
2 Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S., Ishizaki, Y. and Jacobson, M. D. (1994) Programmed cell death and the control of cell survival. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 345, 265-268.   DOI   ScienceOn
3 Jacobson, M. D., Weil, M. and Raff, M. C. (1997) Programmed cell death in animal development. Cell 88, 347-354.   DOI   ScienceOn
4 Park, H. H., Lo, Y. C., Lin, S. C., Wang, L., Yang, J. K. and Wu, H. (2007) The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu. Rev. Immunol. 25, 561-586.   DOI   ScienceOn
5 Scott, F. L., Stec, B., Pop, C., Dobaczewska, M. K., Lee, J. J., Monosov, E., Robinson, H., Salvesen, G. S., Schwarzenbacher, R. and Riedl, S. J. (2009) The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 457, 1019-1022.   DOI   ScienceOn
6 Lee, E. W., Seo, J., Jeong, M., Lee, S. and Song, J. (2012) The roles of FADD in extrinsic apoptosis and necroptosis. BMB Rep. 35, 496-508.   과학기술학회마을   DOI   ScienceOn
7 Jang, T. H., Bae, J. Y., Park, O. K., Kim, J. H., Cho, K. H., Jeon, J. H. and Park, H. H. (2010) Identification and analysis of dominant negative mutants of RAIDD and PIDD. Biochim. Biophys. Acta. 1804, 1557-1563.   DOI   ScienceOn
8 Janssens, S., Tinel, A., Lippens, S. and Tschopp, J. (2005) PIDD mediates NF-kappaB activation in response to DNA damage. Cell 123, 1079-1092.   DOI   ScienceOn
9 Park, H. H. and Wu, H. (2007) Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 63, 229-232.   DOI   ScienceOn
10 Baptiste-Okoh, N., Barsotti, A. M. and Prives, C. (2008) A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc. Natl. Acad. Sci. U. S. A. 105, 1937-1942.   DOI   ScienceOn
11 Lin, Y., Ma, W. and Benchimol, S. (2000) Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat. Genet. 26, 122-127.   DOI   ScienceOn
12 Wu, Z. H., Mabb, A. and Miyamoto, S. (2005) PIDD: a switch hitter. Cell 123, 980-982.   DOI   ScienceOn
13 Reed, J. C., Doctor, K. S. and Godzik, A. (2004) The domains of apoptosis: a genomics perspective. Sci. STKE 2004, re9.
14 Chou, J. J., Matsuo, H., Duan, H. and Wagner, G. (1998) Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94, 171-180.   DOI   ScienceOn
15 Park, H. H. (2011) Structural analyses of death domains and their interactions. Apoptosis. 16, 209-220.   DOI
16 Jang, T. H., Zheng, C., Wu, H., Jeon, J. H. and Park, H. H. (2010) In vitro reconstitution of the interactions in the PIDDosome. Apoptosis. 15, 1444-1452.   DOI   ScienceOn
17 Martinon, F., Mayor, A. and Tschopp, J. (2009) The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265.   DOI   ScienceOn
18 Jang, T. H. and Park, H. H. (2011) Generalized semi-refolding methods for purification of the functional death domain superfamily. J. Biotechnol. 151, 335-342.   DOI   ScienceOn
19 Eberstadt, M., Huang, B., Chen, Z., Meadows, R. P., Ng, S.-C., Zheng, L., Lenardo, M. J. and Fesik, S. W. (1998) NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature 392, 941-945.   DOI   ScienceOn
20 Zou, H., Henzel, W. J., Liu, X., Lutschg, A. and Wang, X. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.   DOI   ScienceOn
21 Martinon, F. and Tschopp, J. (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117, 561-574.   DOI   ScienceOn
22 Park, H. H. (2012) PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway. Apoptosis. 17, 1247-1257.   DOI   ScienceOn
23 Bae, J. Y. and Park, H. H. (2011) Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly. J Biol Chem. 286, 39528-39536.   DOI   ScienceOn
24 Lassus, P., Opitz-Araya, X. and Lazebnik, Y. (2002) Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297, 1352-1354.   DOI   ScienceOn
25 Shin, S., Lee, Y., Kim, W., Ko, H., Choi, H. and Kim, K. (2005) Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J. 24, 3532-3542.   DOI   ScienceOn
26 Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J. and Wu, H. (2007) Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128, 533-546.   DOI   ScienceOn
27 Fisher, D. E. (2001) Pathways of apoptosis and the modulation of cell death in cancer. Hematol. Oncol. Clin. North. Am. 15, 931-956, ix.   DOI
28 Tinel, A., Janssens, S., Lippens, S., Cuenin, S., Logette, E., Jaccard, B., Quadroni, M. and Tschopp, J. (2007) Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 26, 197-208.   DOI   ScienceOn
29 Duan, H. and Dixit, V. M. (1997) RAIDD is a new 'death' adaptor molecule. Nature 385, 86-89.   DOI   ScienceOn
30 Park, H. H. and Wu, H. (2006) Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. J. Mol. Biol. 357, 358-364.   DOI   ScienceOn
31 Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.   DOI   ScienceOn
32 Damiano, J. S. and Reed, J. C. (2004) CARD proteins as therapeutic targets in cancer. Curr. Drug. Targets. 5, 367-374.   DOI   ScienceOn
33 de Graaf, A. O., de Witte, T. and Jansen, J. H. (2004) Inhibitor of apoptosis proteins: new therapeutic targets in hematological cancer? Leukemia. 18, 1751-1759.   DOI   ScienceOn
34 Benoist, C. and Mathis, D. (1997) Cell death mediators in autoimmune diabetes - no shortage of suspects. Cell. 89, 1-3.   DOI   ScienceOn
35 Boatright, K. M. and Salvesen, G. S. (2003) Mechanisms of caspase activation. Curr. Opin. Cell. Biol. 15, 725-731.   DOI   ScienceOn
36 Pop, C. and Salvesen, G. S. (2009) Human caspases: Activation, specificity and regulation. J. Biol. Chem. 284, 21777-21781.   DOI   ScienceOn
37 Harvey, N. L. and Kumar, S. (1998) The role of caspases in apoptosis. Adv. Biochem. Eng. Biotechnol. 62, 107-128.
38 Salvesen, G. S. (2002) Caspases and apoptosis. Essays Biochem. 38, 9-19.   DOI
39 Denault, J. B. and Salvesen, G. S. (2002) Caspases: keys in the ignition of cell death. Chem. Rev. 102, 4489-4500.   DOI   ScienceOn
40 Lavrik, I. N., Golks, A. and Krammer, P. H. (2005) Caspases: pharmacological manipulation of cell death. J. Clin. Invest. 115, 2665-2672.   DOI   ScienceOn
41 Park, H. H. (2012) Structural features of caspase-activating complexes. Int. J. Mol. Sci. 13, 4807-4818.   DOI
42 Tinel, A. and Tschopp, J. (2004) The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304, 843-846.   DOI   ScienceOn
43 Wajant, H. (2002) The Fas signaling pathway: more than a paradigm. Science 296, 1635-1636.   DOI   ScienceOn