[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2013.46.9.228

Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

Shin, Hyoseung (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Yoo, Hyeon Gyeong (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Inui, Shigeki (Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University)
Itami, Satoshi (Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University)
Kim, In Gyu (Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University)
Cho, A-Ri (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Lee, Dong Hun (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Park, Won Seok (Dermatologic Drug Research, Pharmaceutical Research Institute, AmorePacific R&D Center)
Kwon, Ohsang (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Cho, Kwang Hyun (Department of Dermatology, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University)
Won, Chong Hyun (Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan)

Publication Information

BMB Reports / v.46, no.9, 2013 , pp. 460-464 More about this Journal

Abstract

The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)- ${\beta}1$ secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF- ${\beta}1$ secretion is increased by androgen treatment in DP-6, whereas androgen-inducible TGF- ${\beta}1$ was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF- ${\beta}1$ by androgen is mediated by ROS in hair follicle DPCs.

Keywords

Androgenetic alopecia; Androgen receptor; Dermal papilla; Reactive oxygen species; Transforming growth factors;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

1	Foitzik, K., Lindner, G., Mueller-Roever, S., Maurer, M., Botchkareva, N., Botchkarev, V., Handjiski, B., Metz, M., Hibino, T., Soma, T., Dotto, G. P. and Paus, R. (2000) Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB J. 14, 752-760.
2	Sung, Y. K., Hwang, S. Y., Cha, S. Y., Kim, S. R., Park, S. Y., Kim, M. K. and Kim, J. C. (2006) The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative. J. Dermatol. Sci. 41, 150-152. DOI ScienceOn
3	Kwon, O. S., Han, J. H., Yoo, H. G., Chung, J. H., Cho, K. H., Eun, H. C. and Kim, K. H. (2007) Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine 14, 551-555. DOI ScienceOn
4	Yoo, H. G., Kim, J. S., Lee, S. R., Pyo, H. K., Moon, H. I., Lee, J. H., Kwon, O. S., Chung, J. H., Kim, K. H., Eun, H. C. and Cho, K. H. (2006) Perifollicular fibrosis: pathogenetic role in androgenetic alopecia. Biol. Pharm. Bull. 29, 1246-1250. DOI ScienceOn
5	Won, C. H., Kwon, O. S., Kang, Y. J., Yoo, H. G., Lee, D. H., Chung, J. H., Kim, K. H., Park, W. S., Park, N. H., Cho, K., Kwon, S. O., Choi, J. S. and Eun, H. C. (2012) Comparative secretome analysis of human follicular dermal papilla cells and fibroblasts using shotgun proteomics. BMB Rep. 45, 253-258. 과학기술학회마을 DOI ScienceOn
6	Hamada, K., Thornton, M. J., Laing, I., Messenger, A. G. and Randall, V. A. (1996) The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5 alpha- reductase deficiency. J. Invest. Dermatol. 106, 1017-1022. DOI ScienceOn
7	Obana, N., Chang, C. S. and Uno, H. (1997) Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology 138, 356-361. DOI ScienceOn
8	Pan, H. J., Uno, H., Inui, S., Fulmer, N. O. and Chang, C. S. (1999) Roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells. Endocrine 11, 321-327. DOI ScienceOn
9	Inui, S., Fukuzato, Y., Nakajima, T., Yoshikawa, K. and Itami, S. (2002) Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth. FASEB J. 16, 1967-1969.
10	Hogg, N. (1998) Free radicals in disease. Semin. Reprod. Endocrinol. 16, 241-248. DOI ScienceOn
11	Park, S. K., Kim, J., Seomun, Y., Choi, J., Kim, D. H., Han, I. O., Lee, E. H., Chung, S. K. and Joo, C. K. (2001) Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem. Biophys. Res. Commun. 284, 966-971. DOI ScienceOn
12	Ripple, M. O., Henry, W. F., Rago, R. P. and Wilding, G. (1997) Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J. Natl. Cancer Inst. 89, 40-48. DOI ScienceOn
13	Kaufman, K. D. (1996) Androgen metabolism as it affects hair growth in androgenetic alopecia. Dermatol. Clin. 14, 697-711. DOI
14	Hamada, K. and Randall, V. A. (2006) Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. Br. J. Dermatol. 154, 609-618. DOI ScienceOn
15	Haber, R. (2010) Pathogenesis and medical therapy of male and female pattern hair loss; in Hair transplantation, Haber, R. and Stough, D. (eds.), pp. 1-7, Elselvier Saunders, Philadelphia, USA.
16	Trueb, R. M. (2002) Molecular mechanisms of androgenetic alopecia. Exp. Gerontol. 37, 981-990. DOI ScienceOn
17	Hibberts, N. A., Howell, A. E. and Randall, V. A. (1998) Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J. Endocrinol. 156, 59-65. DOI ScienceOn
18	Randall, V. A., Thornton, M. J. and Messenger, A. G. (1992) Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp. J. Endocrinol. 133, 141-147. DOI ScienceOn
19	Sawaya, M. E. and Price, V. H. (1997) Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J. Invest. Dermatol. 109, 296-300. DOI ScienceOn

5	Hyoseung Shin. (2016) Annals of Dermatology Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth / 28 (5) , 600
8	Shigeki Inui. (2014) Experimental Dermatology A newly discovered linkage between proteoglycans and hair biology: decorin acts as an anagen inducer / 23 (8) , 547
1	Hyoseung Shin. (2016) Annals of Dermatology Enhancement of Human Hair Growth UsingEcklonia cavaPolyphenols / 28 (1) , 15
5	James H Upton. (2015) Journal of Investigative Dermatology Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia / 135 (5) , 1244
1	Thomas L. McCarthy. (2015) Gene Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ / 573 (1) , 129
1	Kyu Joong Ahn. (2017) Asian Journal of Beauty and Cosmetology Photoprotective Effects of Caffeic Acid against Ultraviolet-induced Damages on Human Follicle Dermal Papilla Cells / 15 (1) , 105
9	Van-Long Truong. (2017) Molecules Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice / 22 (9) , 1505
2	Kyung Lim. (2015) Molecular Medicine Reports Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells / 12 (2) , 2650
3-4	R. Dey-Rao. (2017) Genomics A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia / 109 (3-4) , 165
8	Laura Jadkauskaite. (2017) BioEssays Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? / 39 (8) , 1700029
1	Seunghee Bae. (2014) Biological Research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells / 47 (1) , 50
2167-8359	(2018) PeerJ Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells / 6 (2167-8359) , e4737
5	(2018) International Journal of Cosmetic Science screening model for hair growth / 40 (5) , 429