Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells |
Zhao, Yan-Fang
(Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University)
Xu, Jing (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Wang, Wen-Juan (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Wang, Jin (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) He, Juan-Wen (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Li, Li (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Dong, Qian (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Xiao, Yan (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Duan, Xing-Lian (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Yang, Xue (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Liang, Yi-Wen (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Song, Tao (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Tang, Min (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Zhao, Dan (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) Luo, Jin-Yong (Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University) |
1 | Heldin, C. H., Miyazono, K. and ten Dijke, P. (1997) TGF-beta signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471. DOI ScienceOn |
2 | Deng, Z. L., Sharff, K. A., Tang, N., Song, W. X., Luo, J., Luo, X., Chen, J., Bennett, E., Reid, R., Manning, D., Xue, A., Montag, A. G., Luu, H. H., Haydon, R. C. and He, T. C. (2008) Regulation of osteogenic differentiation during skeletal development. Front. Biosci. 13, 2001-2021. DOI |
3 | Gallea, S., Lallemand, F., Atfi, A., Rawadi, G., Ramez, V., Spinella-Jaegle, S., Kawai, S., Faucheu, C., Huet, L., Baron, R. and Roman-Roman, S. (2001) Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone 28, 491-498. DOI ScienceOn |
4 | Song, J. J., Celeste, A. J., Kong, F. M., Jirtle, R. L., Rosen, V. and Thies, R. S. (1995) Bone morphogeneticprotein-9 binds to liver cells and stimulates proliferation. Endocrinology 136, 4293-4297. DOI ScienceOn |
5 | Li, C., Yang, X., He, Y., Ye, G., Li, X., Zhang, X., Zhou, L. and Deng, F. (2012) Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner. Int. J. Med. Sci. 9, 862-871. DOI |
6 | Rutherford, R. B., Nussenbaum, B. and Krebsbach, P. H. (2003) Bone morphogenetic protein 7 ex vivo gene therapy. Drug. News Perspect. 16, 5-10. DOI ScienceOn |
7 | Hogan, B. L. (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594. DOI ScienceOn |
8 | Chen, D., Zhao, M. and Mundy, G. R. (2004) Bone morphogenetic proteins. Growth Factors 22, 233-241. DOI ScienceOn |
9 | Boraiah, S., Paul, O., Hawkes, D., Wickham, M. and Lorich, D. G. (2009) Complications of recombinant human BMP-2 for treating complex tibial plateau fractures: a preliminary report. Clin. Orthop. Relat. Res. 467, 3257-3262. DOI ScienceOn |
10 | Kang, Q., Sun, M. H., Cheng, H., Peng, Y., Montag, A. G., Deyrup, A. T., Jiang, W., Luu, H. H., Luo, J., Szatkowski, J. P., Vanichakarn, P., Park, J. Y., Li, Y., Haydon, R. C. and He, T. C. (2004) Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus- mediated gene delivery. Gene Ther. 11, 1312-1320. DOI ScienceOn |
11 | Luu, H. H., Song, W. X., Luo, X., Manning, D., Luo, J., Deng, Z. L., Sharff, K. A., Montag, A. G., Haydon, R. C. and He, T. C. (2007) Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. J. Orthop. Res. 25, 665-677. DOI ScienceOn |
12 | Luo, J., Tang, M., Huang, J., He, B. C., Gao, J. L., Chen, L., Zuo, G. W., Zhang, W., Luo, Q., Shi, Q., Zhang, B. Q., Bi, Y., Luo, X., Jiang, W., Su, Y., Shen, J., Kim, S. H., Huang, E., Gao, Y., Zhou, J. Z., Yang, K., Luu, H. H., Pan, X., Haydon, R. C., Deng, Z. L. and He, T. C. (2010) TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J. Biol. Chem. 285, 29588-29598. DOI ScienceOn |
13 | Wu, N., Zhao, Y., Yin, Y., Zhang, Y. and Luo, J. (2010) Identification and analysis of type II TGF-{beta} receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. Acta. Biochim. Biophys. Sin. (Shanghai). 42, 699-708. DOI ScienceOn |
14 | Zhao, Y., Song, T., Wang, W., Wang, J., He, J., Wu, N., Tang, M., He, B. and Luo, J. (2012) P38 and ERK1/2 MAPKs act in opposition to regulate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. PLoS One 7, e43383. DOI |
15 | Guicheux, J., Lemonnier, J., Ghayor, C., Suzuki, A., Palmer, G. and Caverzasio, J. (2003) Activation of p38 mitogen- activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J. Bone Miner. Res. 18, 2060-2068. DOI ScienceOn |
16 | Liu, H., Liu, Y., Viggeswarapu, M., Zheng, Z., Titus, L. and Boden, S. D. (2011) Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor. J. Bone Miner. Res. 26, 1122-1132. DOI ScienceOn |
17 | Huang, Y. F., Lin, J. J., Lin, C. H., Su, Y. and Hung, S. C. (2012) c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104. J. Bone Miner. Res. 27, 1093-1105. DOI ScienceOn |
18 | Widmann, C., Gibson, S., Jarpe, M. B. and Johnson, G. L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143-180. |
19 | Lopez-Coviella, I., Berse, B., Krauss, R., Thies, R. S. and Blusztajn, J. K. (2000) Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP9. Science 289, 313-316. DOI ScienceOn |
20 | Chen, C., Grzegorzewski, K. J., Baras, S., Zhao, Q., Schneider, H., Wang, Q., Singh, M., Pukac, L., Bell, A. C., Duan, R., Coleman, T., Duttaroy, A., Cheng, S., Hirsch, J., Zhang, L., Lazard, Y., Fischer, C., Barber, M. C., Ma, Z. D., Zhang, Y. Q., Reavey, P., Zhong, L., Teng, B., Sanyal, I., Ruben, S. M., Blondel, O. and Birse, C. E. (2003) An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat. Biotechnol. 21, 294-301. DOI ScienceOn |
21 | Sovershaev, M. A., Egorina, E. M., Sovershaev, T. A., Svensson, B. and Hansen, J. B. (2011) Increased expression of TF in BMP-7-treated human mononuclear cells depends on activation of select MAPK signaling pathways. Thromb. Res. 128, e154-159. DOI ScienceOn |
22 | Truksa, J., Peng, H., Lee, P. and Beutler, E. (2006) Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferring receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. U.S.A. 103, 10289-10291. DOI ScienceOn |
23 | Tian, X. Y., Yung, L. H., Wong, W. T., Liu, J., Leung, F. P., Liu, L., Chen, Y., Kong, S. K., Kwan, K. M., Ng, S. M., Lai, P. B., Yung, L. M., Yao, X. and Huang, Y. (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. J. Mol. Cell Cardiol. 52, 237-244. DOI ScienceOn |